Human papillomavirus infection is caused by a DNA virus from the Papillomaviridae family. Many HPV infections cause no symptoms and 90% resolve spontaneously within two years. In some cases, an HPV infection persists and results in either warts or precancerous lesions. These lesions, depending on the site affected, increase the risk of cancer of the cervix, vulva, vagina, penis, anus, mouth, tonsils, or throat. Nearly all cervical cancer is due to HPV, and two strains – HPV16 and HPV18 – account for 70% of all cases. HPV16 is responsible for almost 90% of HPV-positive oropharyngeal cancers. Between 60% and 90% of the other cancers listed above are also linked to HPV. HPV6 and HPV11 are common causes of genital warts and laryngeal papillomatosis.
Laryngeal papillomatosis, also known as recurrent respiratory papillomatosis (RRP) or glottal papillomatosis, is a rare medical condition in which benign tumors (papilloma) form along the aerodigestive tract. There are two variants based on the age of onset: juvenile and adult laryngeal papillomatosis. The tumors are caused by human papillomavirus (HPV) infection of the throat. The tumors may lead to narrowing of the airway, which may cause vocal changes or airway obstruction. Laryngeal papillomatosis is initially diagnosed through indirect laryngoscopy upon observation of growths on the larynx and can be confirmed through a biopsy. Treatment for laryngeal papillomatosis aims to remove the papillomas and limit their recurrence. Due to the recurrent nature of the virus, repeated treatments usually are needed. Laryngeal papillomatosis is primarily treated surgically, though supplemental nonsurgical and/or medical treatments may be considered in some cases. The evolution of laryngeal papillomatosis is highly variable. Though total recovery may be observed, it is often persistent despite treatment. The number of new cases of laryngeal papillomatosis cases is approximately 4.3 cases per 100,000 children and 1.8 cases per 100,000 adults annually.
A papilloma is a benign epithelial tumor growing exophytically in nipple-like and often finger-like fronds. In this context, papilla refers to the projection created by the tumor, not a tumor on an already existing papilla.
Bovine papillomaviruses (BPV) are a paraphyletic group of DNA viruses of the subfamily Firstpapillomavirinae of Papillomaviridae that are common in cattle. All BPVs have a circular double-stranded DNA genome. Infection causes warts of the skin and alimentary tract, and more rarely cancers of the alimentary tract and urinary bladder. They are also thought to cause the skin tumour equine sarcoid in horses and donkeys.
North Shore University Hospital is a part of Northwell Health, New York State's largest healthcare provider and private employer. It is a primary teaching hospital for the Zucker School of Medicine, offering residency programs, postgraduate training programs and clinical fellowships. It is located in Manhasset, New York, in Nassau County, on Long Island.
Margaret Anne Stanley, OBE FMedSc, is a British virologist and epithelial biologist. She attended the Universities of London, Bristol, and Adelaide. As of 2018, she is an Emeritus Professor of Epithelial Biology in the Department of Pathology at the University of Cambridge and a Fellow of the Academy of Medical Sciences. She is also an Honorary Fellow of the UK Royal College of Obstetricians and Gynaecologists and an honorary fellow of Christ's College, Cambridge. Stanley is a research scientist in virology focusing on the human papillomavirus (HPV). Her research work has led to new scientific findings on HPV. Additionally, she uses her expertise on HPV to serve on multiple advisory committees and journal editorial boards.
Stuart Rabinowitz was the 8th president of Hofstra University. Before assuming the presidency, he was dean of Hofstra Law School for over a decade and before that was a distinguished professor of law.
The Feinstein Institutes for Medical Research in Manhasset, Nassau County, New York, United States, on Long Island, constitute the research arm of Northwell Health. Feinstein is home to 50 research labs, 2,500 clinical research studies, and 5,000 professional and support staff. Feinstein scientists conduct research in molecular medicine, genetics, cancer, brain research, mental health, autoimmunity and bioelectronic medicine, among others. Feinstein is the laboratory and faculty home of the Elmezzi Graduate School of Molecular Medicine. Students without an MD degree may earn a PhD in molecular medicine via the Zucker School of Medicine, as part of the medical school's MD/PhD or PhD programs.
Betty Diamond is an American physician and researcher. She is director of the Institute of Molecular Medicine at Northwell Health's Feinstein Institute for Medical Research in Manhasset, NY. She was elected a member of the National Academy of Sciences in 2022.
Northwell Health is a nonprofit integrated healthcare network that is New York State's largest healthcare provider and private employer, with more than 81,000 employees.
Stephen E. Dolgin is an American pediatric surgeon, and professor of Surgery at Zucker School of Medicine at Hofstra/Northwell. He is a consultant at Cohen Children’s Medical Center, the pediatric hub of Northwell Health.
Yousef Al-Abed is the head of the Center for Molecular Innovation at the Northwell's Feinstein Institute for Medical Research, in Manhasset, New York. An organic chemist by training, Al-Abed holds dual-appointment as a Professor of Molecular Medicine and Medicine at Hofstra Northwell School of Medicine.
Anna-Lise WilliamsonMASSAf is a Professor of Virology at the University of Cape Town. Williamson obtained her PhD from the University of the Witwatersrand in 1985. Her area of expertise is human papillomavirus, but is also known on an international level for her work in developing vaccines for HIV. These vaccines have been introduce in phase 1 of clinical trial. Williamson has published more than 120 papers.
The Zucker School of Medicine is the graduate medical school of Hofstra University in the town of Hempstead on Long Island, in the U.S. state of New York. The academic institution was established in 2008 by Hofstra University and the North Shore-LIJ Hospital system which was rebranded as Northwell Health in 2015. The Zucker School of Medicine enrolls 99 students each year and offers an MD and PhD. It also offers a joint MD—PhD degree; joint MD—MPH ; joint MD—MBA ; and joint MD—OMS. It also offers a dual-degree "4+4" program comprising an undergraduate degree followed by automatic matriculation to the School of Medicine.
Long Island Jewish Forest Hills is a teaching hospital operating under the Northwell Health hospital network. It is located in Forest Hills, Queens, New York. The hospital is affiliated with the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, which sponsors a residency program in internal medicine. The hospital also serves as the host of a podiatry residency program.
John M. Kane is an American psychiatrist who served as the Chair of Psychiatry at the Zucker Hillside Hospital for 34 years. He also served as the Chair of Psychiatry at The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell for its first 12 years. He stepped down from these roles in 2022 to focus his efforts on his research and mentorship of early career investigators as co-director, Institute of Behavioral Science at the Feinstein Institutes for Medical Research, part of Northwell Health.
Daniel O’Connell Griffin is an American infectious disease specialist. He is president of the nonprofit organization Parasites Without Borders.
Maura Lianne Gillison is an American medical oncologist and molecular epidemiologist. She is credited as the first investigator to establish a connection between HPV and oral cancer.
Eftyhia Vardas FC Path is an honorary extraordinary professor in medical virology at the Department of Medical Virology, University of Stellenbosch, and head of virology at Lancet Laboratories in Johannesburg. She is a member of the COVID-19 Ministerial Advisory Committee to the South African minister of health.
Aimée Rebecca Kreimer is an American cancer epidemiologist who researches the etiology and prevention of human papillomavirus infection (HPV) and cancer prevention. She is a senior investigator in the infections and immunoepidemiology branch at the National Cancer Institute.
