Edward J. Steele

Last updated

Edward J. Steele
Edward J. Steele, Phd.jpg
Born (1948-10-27) 27 October 1948 (age 74)
Citizenship Australian
Known for Somatic Hypermutation
Scientific career
Fields Biology
Virology
InstitutionsUniversity of Adelaide [1971-1975], University of Toronto (Ontario Cancer Institute) [1977-1980], Australian National University (John Curtin School of Medical Research [1975-1977, 1981-1985], University of Wollongong [1985-2003], CYO’Connor ERADE Foundation 24 Genomics Rise, Piara Waters, WA, Australia[2009-2010, 2014 - ]
Doctoral advisor Professor Derrick Rowley, Department of Microbiology, University of Adelaide 1970 -1975

Qualifications : BSc (Hons), PhD, ASCIA, AIMS, ASI

( Membership Key = ASCIA- Australian Society of Clinical Immunology and Allergy; AIMS, Australian Institute of Medical Sciences; ASI – Australian Society for Immunology)

Edward J. "Ted" Steele is an Australian molecular immunologist with interests in virology and evolution. He is an honorary research associate at the C.Y.O'Connor ERADE Village Foundation in Piara Waters, WA, Australia.

Contents

Scientific interests

Ted Steele hypothesized the RNA/RT-based mechanism of somatic hypermutation.

This is known as neo-Lamarckism. [1] Steele's hypothesis provided the first mechanism to explain Lamarckian evolution: when successful somatic cell changes occur due to environmental changes, copies of the copious new messenger-RNA that have been produced by the successful cells are picked up by harmless retroviruses acting as gene shuttles and transported across the tissue barrier – the Weismann Barrier – to the germline. Finally, the new genetic information is integrated into the DNA by a process involving reverse transcription. This process of writing or translating new information into the DNA provides the essential precursor to acquired changes being passed on to progeny; to the next generation, thereby demonstrating Lamarckian inheritance of acquired characters. Darwinian natural selection then goes to work on the progeny and subsequent generations: those fit for survival do so and those not fit die out. This recombination of Darwin and Lamarck by Steele has been described as meta-Lamarckism. [2]

During the 1980s and 1990s, Ted Steele clashed with the scientific establishment, particularly in the UK, over this hypothesis and his support for Lamarck's place in modern science. Steele has stated publicly in an interview with the ABC program Lateline that his controversial theories have had a strong impact on his career: "To be branded a heretic and a pariah meant that my career to keep doing research in this area were extremely limited." [3]

From 2010 to 2018, Ted Steele continued to explore reverse transcription as a mechanism to explain the emergence of complex retroviruses of vertebrate lines at or just before the Cambrian Explosion of ~500 Ma.[ citation needed ]

Dismissal and dispute

In January 2001, Steele made several allegations to the media in regard to 'soft' marking resulting in the upgrading of full fee paying international students. Steele was summarily dismissed by UoW's Vice-Chancellor Gerard Sutton, stating that the university's reputation was "placed at a serious and imminent risk as a result of Associate Professor Steele's claims." Steele declared his dismissal unfair and instituted legal proceedings. The case received wide media coverage. [4]

In August 2001, the Australian Federal Court found that the University of Wollongong had breached its staff enterprise agreement by not following correct conduct and dismissal procedures in Steele's case. Following the verdict Steele expressed publicly that he wanted his job back. [5]

On 5 April 2002, UoW Vice Chancellor Gerard Sutton acceded to NTEU demands and reinstated Steele to his position within the Department of Biological Sciences at the University of Wollongong. It was made public that Steele's reinstatement was unconditional and involved backpay. President of the National Tertiary Education Union, Carolyn Allport, announced the importance of the victory and precedent that the court's ruling set. "The NTEU has said all along that Dr Steele was dismissed illegally. The union's position has been completely vindicated by the findings of four judges of the Federal Court and Dr Steele's subsequent reinstatement. The reinstatement comes after a 15 month legal and political campaign by the NTEU. It is a victory for all NTEU members because it clearly demonstrates that university staff cannot be dismissed without a proper and fair hearing. This requirement is the fundamental protection of intellectual freedom in Australia's universities and the successful campaign to reinstate Dr Steele has reaffirmed that protection for all Australian university staff and for the community that our universities serve." [6]

The unfair dismissal issue was resolved on 6 July 2002 when Steele and the University of Wollongong came to a confidential agreement.

COVID-19

In 2020, Steele, along with researcher N. Chandra Wickramasinghe and others, claimed in ten research papers that COVID-19 originated from a meteor spotted as a bright fireball over the city of Songyuan in Northeast China on October 11, 2019, and that a fragment of the meteor landed in the Wuhan area, which started the first COVID-19 outbreaks. However, the researchers, including Steele, did not provide any direct evidence proving this theory. [7] The pseudonymous science blogger Neuroskeptic, writing in Astronomy magazine, called the meteor origin theory "so remarkable that it makes the others look boring by comparison". [7]

Selected publications

See also

Related Research Articles

<span class="mw-page-title-main">Heredity</span> Passing of traits to offspring from the species parents or ancestor

Heredity, also called inheritance or biological inheritance, is the passing on of traits from parents to their offspring; either through asexual reproduction or sexual reproduction, the offspring cells or organisms acquire the genetic information of their parents. Through heredity, variations between individuals can accumulate and cause species to evolve by natural selection. The study of heredity in biology is genetics.

<span class="mw-page-title-main">Pangenesis</span> Darwins proposed mechanism for heredity

Pangenesis was Charles Darwin's hypothetical mechanism for heredity, in which he proposed that each part of the body continually emitted its own type of small organic particles called gemmules that aggregated in the gonads, contributing heritable information to the gametes. He presented this 'provisional hypothesis' in his 1868 work The Variation of Animals and Plants Under Domestication, intending it to fill what he perceived as a major gap in evolutionary theory at the time. The etymology of the word comes from the Greek words pan and genesis ("birth") or genos ("origin"). Pangenesis mirrored ideas originally formulated by Hippocrates and other pre-Darwinian scientists, but using new concepts such as cell theory, explaining cell development as beginning with gemmules which were specified to be necessary for the occurrence of new growths in an organism, both in initial development and regeneration. It also accounted for regeneration and the Lamarckian concept of the inheritance of acquired characteristics, as a body part altered by the environment would produce altered gemmules. This made Pangenesis popular among the neo-Lamarckian school of evolutionary thought. This hypothesis was made effectively obsolete after the 1900 rediscovery among biologists of Gregor Mendel's theory of the particulate nature of inheritance.

<span class="mw-page-title-main">Neo-Darwinism</span> Used to describe the combination of natural selection and genetics

Neo-Darwinism is generally used to describe any integration of Charles Darwin's theory of evolution by natural selection with Gregor Mendel's theory of genetics. It mostly refers to evolutionary theory from either 1895 or 1942, but it can mean any new Darwinian- and Mendelian-based theory, such as the current evolutionary theory.

<span class="mw-page-title-main">August Weismann</span> German evolutionary biologist (1834–1914)

August Friedrich Leopold Weismann FRS (For), HonFRSE, LLD was a German evolutionary biologist. Fellow German Ernst Mayr ranked him as the second most notable evolutionary theorist of the 19th century, after Charles Darwin. Weismann became the Director of the Zoological Institute and the first Professor of Zoology at Freiburg.

<span class="mw-page-title-main">Modern synthesis (20th century)</span> Fusion of natural selection with Mendelian inheritance

The modern synthesis was the early 20th-century synthesis of Charles Darwin's theory of evolution and Gregor Mendel's ideas on heredity into a joint mathematical framework. Julian Huxley coined the term in his 1942 book, Evolution: The Modern Synthesis.

<span class="mw-page-title-main">Jean-Baptiste Lamarck</span> French naturalist (1744–1829)

Jean-Baptiste Pierre Antoine de Monet, chevalier de Lamarck, often known simply as Lamarck, was a French naturalist, biologist, academic, and soldier. He was an early proponent of the idea that biological evolution occurred and proceeded in accordance with natural laws.

<span class="mw-page-title-main">Lamarckism</span> Scientific hypothesis about inheritance

Lamarckism, also known as Lamarckian inheritance or neo-Lamarckism, is the notion that an organism can pass on to its offspring physical characteristics that the parent organism acquired through use or disuse during its lifetime. It is also called the inheritance of acquired characteristics or more recently soft inheritance. The idea is named after the French zoologist Jean-Baptiste Lamarck (1744–1829), who incorporated the classical era theory of soft inheritance into his theory of evolution as a supplement to his concept of orthogenesis, a drive towards complexity.

<span class="mw-page-title-main">Genetic variation</span> Difference in DNA among individuals or populations

Genetic variation is the difference in DNA among individuals or the differences between populations among the same species. The multiple sources of genetic variation include mutation and genetic recombination. Mutations are the ultimate sources of genetic variation, but other mechanisms, such as genetic drift, contribute to it, as well.

<span class="mw-page-title-main">Weismann barrier</span> Distinction between germ cell lineages producing gametes and somatic cells

The Weismann barrier, proposed by August Weismann, is the strict distinction between the "immortal" germ cell lineages producing gametes and "disposable" somatic cells in animals, in contrast to Charles Darwin's proposed pangenesis mechanism for inheritance. In more precise terminology, hereditary information moves only from germline cells to somatic cells. This does not refer to the central dogma of molecular biology, which states that no sequential information can travel from protein to DNA or RNA, but both hypotheses relate to a gene-centric view of life.

<span class="mw-page-title-main">Baldwin effect</span> Effect of learned behavior on evolution

In evolutionary biology, the Baldwin effect, a phenotype-first theory of evolution, describes the effect of learned behaviour on evolution. James Mark Baldwin and others suggested during the eclipse of Darwinism in the late 19th century that an organism's ability to learn new behaviours will affect its reproductive success and will therefore have an effect on the genetic makeup of its species through natural selection. Though this process appears similar to Lamarckism, that view proposes that living things inherited their parents' acquired characteristics. The Baldwin effect has been independently proposed several times, and today it is generally recognized as part of the modern synthesis.

<span class="mw-page-title-main">Germ plasm</span> Biological concept

Germ plasm is a biological concept developed in the 19th century by the German biologist August Weismann. It states that heritable information is transmitted only by germ cells in the gonads, not by somatic cells. The related idea that information cannot pass from somatic cells to the germ line, contrary to Lamarckism, is called the Weismann barrier. To some extent this theory anticipated the development of modern genetics.

<span class="mw-page-title-main">Blending inheritance</span> Obsolete theory of genetics

Blending inheritance is an obsolete theory in biology from the 19th century. The theory is that the progeny inherits any characteristic as the average of the parents' values of that characteristic. As an example of this, a crossing of a red flower variety with a white variety of the same species would yield pink-flowered offspring.

Ivan Ivanovich Schmalhausen was a Ukrainian, Russian and later Soviet zoologist and evolutionary biologist of German descent. He developed the theory of stabilizing selection, and took part in the development of the modern evolutionary synthesis.

Julian Huxley used the phrase "the eclipse of Darwinism" to describe the state of affairs prior to what he called the "modern synthesis". During the "eclipse", evolution was widely accepted in scientific circles but relatively few biologists believed that natural selection was its primary mechanism. Historians of science such as Peter J. Bowler have used the same phrase as a label for the period within the history of evolutionary thought from the 1880s to around 1920, when alternatives to natural selection were developed and explored—as many biologists considered natural selection to have been a wrong guess on Charles Darwin's part, or at least to be of relatively minor importance.

<span class="mw-page-title-main">Ludwig Hermann Plate</span> German zoologist (1862–1937)

Ludwig Hermann Plate was a German zoologist and student of Ernst Haeckel. He wrote a "thorough and extensive defence" of Darwinism, but before Mendel's work had been assimilated in the modern synthesis.

This article considers the history of zoology since the theory of evolution by natural selection proposed by Charles Darwin in 1859.

<span class="mw-page-title-main">Transgenerational epigenetic inheritance</span> Epigenetic transmission without DNA primary structure alteration

Transgenerational epigenetic inheritance is the transmission of epigenetic markers and modifications from one generation to multiple subsequent generations without altering the primary structure of DNA. Thus, the regulation of genes via epigenetic mechanisms can be heritable; the amount of transcripts and proteins produced can be altered by inherited epigenetic changes. In order for epigenetic marks to be heritable, however, they must occur in the gametes in animals, but since plants lack a definitive germline and can propagate, epigenetic marks in any tissue can be heritable.

Joseph Thomas Cunningham (1859–1935) was a British marine biologist and zoologist known for his experiments on flatfish and his writings on neo-Lamarckism.

<span class="mw-page-title-main">Alternatives to Darwinian evolution</span> List of alternatives to Darwinian natural selection

Alternatives to Darwinian evolution have been proposed by scholars investigating biology to explain signs of evolution and the relatedness of different groups of living things. The alternatives in question do not deny that evolutionary changes over time are the origin of the diversity of life, nor that the organisms alive today share a common ancestor from the distant past ; rather, they propose alternative mechanisms of evolutionary change over time, arguing against mutations acted on by natural selection as the most important driver of evolutionary change.

<span class="mw-page-title-main">Evolution in fiction</span> Role of evolution as a theme in fiction

Evolution has been an important theme in fiction, including speculative evolution in science fiction, since the late 19th century, though it began before Charles Darwin's time, and reflects progressionist and Lamarckist views as well as Darwin's. Darwinian evolution is pervasive in literature, whether taken optimistically in terms of how humanity may evolve towards perfection, or pessimistically in terms of the dire consequences of the interaction of human nature and the struggle for survival. Other themes include the replacement of humanity, either by other species or by intelligent machines.

References

  1. The implications of Steele's soma-to-germline feedback for the safety of somatic gene therapy in humans
  2. Honeywill, Ross (2008). "ESSAY: The Case for Meta-Lamarckism – Lamarck's Evolution" . Retrieved 1 August 2016.
  3. Jennifer Byrne, David Ransom (8 October 1998). "Rethinking Darwin". Lateline . Australian Broadcasting Corp . Retrieved 1 August 2016.
  4. When dollars do all the talking - "The sacking of an academic suggests that commercial issues outweigh free speech" The Australian, 18 April 2001, p. 35 (Brian Martin)
  5. Story from ABC News
  6. "Ted Steele reinstated - University of Wollongong finally comes to its senses NTEU archives". Archived from the original on 7 September 2007. Retrieved 13 August 2007.
  7. 1 2 "Wild theory suggests COVID-19 came to Earth aboard a space rock". Astronomy.com . 31 August 2020. Retrieved 29 March 2021.

Further reading