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Gregor Johann Mendel, OSA was a biologist, meteorologist, mathematician, Augustinian friar and abbot of St. Thomas' Abbey in Brünn (Brno), Margraviate of Moravia. Mendel was born in a German-speaking family in the Silesian part of the Austrian Empire and gained posthumous recognition as the founder of the modern science of genetics. Though farmers had known for millennia that crossbreeding of animals and plants could favor certain desirable traits, Mendel's pea plant experiments conducted between 1856 and 1863 established many of the rules of heredity, now referred to as the laws of Mendelian inheritance.
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mitosis, or meiosis or other types of damage to DNA, which then may undergo error-prone repair, cause an error during other forms of repair, or cause an error during replication. Mutations may also result from insertion or deletion of segments of DNA due to mobile genetic elements.
Thomas Hunt Morgan was an American evolutionary biologist, geneticist, embryologist, and science author who won the Nobel Prize in Physiology or Medicine in 1933 for discoveries elucidating the role that the chromosome plays in heredity.
Evolutionary developmental biology is a field of biological research that compares the developmental processes of different organisms to infer how developmental processes evolved.
The modern synthesis was the early 20th-century synthesis reconciling Charles Darwin's theory of evolution and Gregor Mendel's ideas on heredity in a joint mathematical framework. Julian Huxley coined the term in his 1942 book, Evolution: The Modern Synthesis.
Max Ludwig Henning Delbrück was a German–American biophysicist who participated in launching the molecular biology research program in the late 1930s. He stimulated physical scientists' interest into biology, especially as to basic research to physically explain genes, mysterious at the time. Formed in 1945 and led by Delbrück along with Salvador Luria and Alfred Hershey, the Phage Group made substantial headway unraveling important aspects of genetics. The three shared the 1969 Nobel Prize in Physiology or Medicine "for their discoveries concerning the replication mechanism and the genetic structure of viruses". He was the first physicist to predict what is now called Delbrück scattering.
Calvin Blackman Bridges was an American scientist known for his contributions to the field of genetics. Along with Alfred Sturtevant and H.J. Muller, Bridges was part of Thomas Hunt Morgan's famous "Fly Room" at Columbia University.
Hermann Joseph Muller was an American geneticist, educator, and Nobel laureate best known for his work on the physiological and genetic effects of radiation (mutagenesis), as well as his outspoken political beliefs. Muller frequently warned of long-term dangers of radioactive fallout from nuclear war and nuclear testing, which resulted in greater public scrutiny of these practices.
Genetic variation is the difference in DNA among individuals or the differences between populations. The multiple sources of genetic variation include mutation and genetic recombination. Mutations are the ultimate sources of genetic variation, but other mechanisms, such as sexual reproduction and genetic drift, contribute to it, as well.
Evolutionary biology is the subfield of biology that studies the evolutionary processes that produced the diversity of life on Earth. Simply, it is also defined as the study of the history of life forms on Earth. Evolution is based on the theory that all species are related and they gradually change over time. In a population, the genetic variations affect the physical characteristics i.e. phenotypes of an organism. These changes in the phenotypes will be an advantage to some organisms, which will then be passed onto their offspring. Peppered Moth and Flightless birds are some examples of evolution in species over many generations. In the 1930s, the discipline of evolutionary biology emerged through what Julian Huxley called the modern synthesis of understanding, from previously unrelated fields of biological research, such as genetics and ecology, systematics, and paleontology. A person who studies Evolutionary biology is called an Evolutionary biologist. The importance of studying Evolutionary biology is mainly to understand the principles behind the origin and extinction of species.
Eric Francis Wieschaus is an American evolutionary developmental biologist and 1995 Nobel Prize-winner.
Mutationism is one of several alternatives to evolution by natural selection that have existed both before and after the publication of Charles Darwin's 1859 book On the Origin of Species. In the theory, mutation was the source of novelty, creating new forms and new species, potentially instantaneously, in sudden jumps. This was envisaged as driving evolution, which was thought to be limited by the supply of mutations.
The history of genetics dates from the classical era with contributions by Pythagoras, Hippocrates, Aristotle, Epicurus, and others. Modern genetics began with the work of the Augustinian friar Gregor Johann Mendel. His work on pea plants, published in 1866, established the theory of Mendelian inheritance.
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Charlotte "Lotte" Auerbach FRS FRSE was a German geneticist who contributed to founding the science of mutagenesis. She became well known after 1942 when she discovered with A. J. Clark and J. M. Robson that mustard gas could cause mutations in fruit flies. She wrote 91 scientific papers, and was a Fellow of the Royal Society of Edinburgh and of the Royal Society of London.
Neutral mutations are changes in DNA sequence that are neither beneficial nor detrimental to the ability of an organism to survive and reproduce. In population genetics, mutations in which natural selection does not affect the spread of the mutation in a species are termed neutral mutations. Neutral mutations that are inheritable and not linked to any genes under selection will either be lost or will replace all other alleles of the gene. This loss or fixation of the gene proceeds based on random sampling known as genetic drift. A neutral mutation that is in linkage disequilibrium with other alleles that are under selection may proceed to loss or fixation via genetic hitchhiking and/or background selection.
H. Allen Orr is the Shirley Cox Kearns Professor of Biology at the University of Rochester.
James Alan Shapiro is an American biologist, an expert in bacterial genetics and a professor in the Department of Biochemistry and Molecular Biology at the University of Chicago.
The one gene–one enzyme hypothesis is the idea that genes act through the production of enzymes, with each gene responsible for producing a single enzyme that in turn affects a single step in a metabolic pathway. The concept was proposed by George Beadle and Edward Tatum in an influential 1941 paper on genetic mutations in the mold Neurospora crassa, and subsequently was dubbed the "one gene–one enzyme hypothesis" by their collaborator Norman Horowitz. In 2004, Horowitz reminisced that "these experiments founded the science of what Beadle and Tatum called 'biochemical genetics.' In actuality they proved to be the opening gun in what became molecular genetics and all the developments that have followed from that." The development of the one gene–one enzyme hypothesis is often considered the first significant result in what came to be called molecular biology. Although it has been extremely influential, the hypothesis was recognized soon after its proposal to be an oversimplification. Even the subsequent reformulation of the "one gene–one polypeptide" hypothesis is now considered too simple to describe the relationship between genes and proteins.
The Blood of the Nation: A Study in the Decay of Races by the Survival of the Unfit was the title of a number of publications by the American eugenicist David Starr Jordan, the president of Stanford University. His thesis, under the same name, first appeared in the May 1901 edition of Popular Science Monthly. It was republished in book form by the American Unitarian Association in 1902 and again in 1910. It was intended to promote the eugenics movement and bring its aims to a broader non-academic audience.
References
- 1 2 "Semester At Sea - Fall 2001". Archived from the original on 2006-10-21. Retrieved 2007-11-13.
- ↑ "USB Honors by Faculty Member". Archived from the original on 2007-06-30. Retrieved 2007-11-13.
- ↑ "Office of Undergraduate Studies". Archived from the original on 2008-01-15. Retrieved 2007-11-13.
- ↑ Thompson, R. Paul (2009). "Reviews and Brief Notices. Review of Neither Gods Nor Beasts: How Science Is Changing Who We Think We Are by Elof Axel Carlson" (PDF). The Quarterly Review of Biology. 84 (2): 177–178. doi:10.1086/598823.
- ↑ Harper, Peter S. (2011). "Review of Mutation: the history of an idea from Darwin to genomics by Elof Axel Carlson". Human Genetics. 131 (1): 157–158. doi:10.1007/s00439-011-1070-1. ISSN 0340-6717. S2CID 44446630.
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