Fibrinogen beta chain

Last updated
FGB
Protein FGB PDB 1fza.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FGB , HEL-S-78p, fibrinogen beta chain
External IDs OMIM: 134830 MGI: 99501 HomoloGene: 3772 GeneCards: FGB
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001184741
NM_005141

NM_181849

RefSeq (protein)

NP_862897

Location (UCSC) Chr 4: 154.56 – 154.57 Mb Chr 3: 82.95 – 82.96 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Fibrinogen beta chain, also known as FGB, is a gene found in humans and most other vertebrates with a similar system of blood coagulation.

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [5]

Interactions

Fibrinogen beta chain has been shown to interact with Lipoprotein(a). [6]

See also


Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171564 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033831 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FGB fibrinogen beta chain".
  6. Klose R, Fresser F, Kochl S, Parson W, Kapetanopoulos A, Fruchart-Najib J, Baier G, Utermann G (December 2000). "Mapping of a minimal apolipoprotein(a) interaction motif conserved in fibrin(ogen) beta - and gamma -chains". J. Biol. Chem. 275 (49). UNITED STATES: 38206–12. doi: 10.1074/jbc.M003640200 . ISSN   0021-9258. PMID   10980194.

Further reading