Global Burden of Disease Study

Last updated

The Global Burden of Disease Study (GBD) is a comprehensive regional and global research program of disease burden that assesses mortality and disability from major diseases, injuries, and risk factors. GBD is a collaboration of over 3600 researchers from 145 countries. [1] Under principal investigator Christopher J.L. Murray, GBD is based in the Institute for Health Metrics and Evaluation (IHME) at the University of Washington and funded by the Bill and Melinda Gates Foundation. [2]

Contents

History

The Global Burden of Disease Study began in 1990 as a single World Bank-commissioned [3] study that quantified the health effects of more than 100 diseases and injuries for eight regions of the world, giving estimates of morbidity and mortality by age, sex, and region. It also introduced the disability-adjusted life year (DALY) as a new metric to quantify the burden of diseases, injuries, and risk factors, [4] [5] [6] to aid comparisons. GBD 1990 was "institutionalized" at the World Health Organization (WHO) and the research was "conducted mainly by researchers at Harvard and WHO". [3]

In 2000–2002, the 1990 study was updated by WHO to include a more extensive analysis using a framework known as comparative risk factor assessment. [5]

The WHO estimates were again updated for 2004 in The global burden of disease: 2004 update (published in 2008) [7] and in Global health risks (published in 2009). [5] [8]

Official DALY estimates had not been updated by WHO since 2004 [9] until the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010), also known as the Global Burden of Disease Study 2010, [10] was published in December 2012. [11] [12] The work quantified the burdens of 291 major causes of death and disability and 67 risk factors disaggregated by 21 geographic regions and various age–sex groups. [13] [14] GBD 2010 had the Institute for Health Metrics and Evaluation as its coordinating center, but was a collaboration between several institutions including WHO and the Harvard School of Public Health. [13] The work was funded by the Gates Foundation. [3] The GBD 2010 estimates contributed to WHO's own estimates published in 2013, [5] although WHO did not acknowledge the GBD 2010 estimates. [15] [16]

The Global Burden of Disease Study 2013 (GBD 2013) was published in 2014. [17] The first installment, "Smoking Prevalence and Cigarette Consumption in 187 Countries, 1980–2012", was published in the Journal of the American Medical Association in January, and further installments were published throughout the year. [11] IHME continued to act as the coordinating center for the work. [18]

The Global Burden of Disease Study 2017 (GBD 2017) was published in October 2018. [19] The work was still coordinated at IHME. The life of Christopher Murray and the Global Burden of Disease Study is told in Epic Measures: One Doctor. Seven Billion Patients by Jeremey N. Smith. [20]

GBD 2019 was published in The Lancet in October 2020. [21]

GBD 2021 was published in The Lancet in February to May 2024, including an impact assessment of the COVID-19 pandemic as well as projections by 2050. [22] Fact sheets are provided for all topics. [23] The estimates are also available through an online tool and data files, for which a registration is required. [24]

Growth

The following table summarizes GBD's growth over the years.

ReportCollaboratorsCoverage in reportSources
GBDPublication yearResearchersCountriesCountriesCauses of death
19901993 [25]
2010201248850187235 [11] [17] [26]
20132014more than 1,000106188240 [17]
201520161,870127195249 [27] [28] [29]
20172018 [19]
20192020Over 5,000152204 [21]
20212024Over 12,000over 160204288 [22]

Aims

The GBD has three specific aims:[ citation needed ]

  1. To systematically incorporate information on non-fatal outcomes into the assessment of the health status (using a time-based measure of healthy years of life lost due either to premature mortality or to years lived with a disability, weighted by the severity of that disability)
  2. To ensure that all estimates and projections were derived on the basis of objective epidemiological and demographic methods, which were not influenced by advocates.
  3. To measure the burden of disease using a metric that could also be used to assess the cost-effectiveness of interventions. The metric chosen was the DALY (Disability Adjusted Life Years).[ citation needed ]

The burden of disease can be viewed as the gap between current health status and an ideal situation in which everyone lives into old age free of disease and disability. Causes of the gap are premature mortality, disability and exposure to certain risk factors that contribute to illness.[ citation needed ]

Results

The 2013 report showed that global life expectancy for both sexes increased from 65.3 years in 1990, to 71.5 years in 2013, [17] while the number of deaths increased from 47.5 million to 54.9 million over the same interval. [17] Progress varied widely across demographic and national groups. Reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections and neonatal causes in low-income regions drove the changes. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa.[ citation needed ]

For most communicable causes of death both numbers of deaths and age-standardised death rates fell, while for most non-communicable causes, demographic shifts increased numbers of deaths but decreased age-standardised death rates.[ citation needed ]

Global deaths from injury increased by 10.7%, from 4.3 million deaths in 1990 to 4.8 million in 2013; but age-standardised rates declined over the same period by 21%. [17] For some causes of more than 100,000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes and malaria remain in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. [17]

GBD 2015 found that for the first time, annual deaths from measles had fallen below 100,000 in 2013 and 2015. [30] [31] [32] It also found that the global annual rate of new HIV infections has largely stayed the same during the past 10 years. [33]

GBD 2015 also introduced the Socio-demographic Index (SDI) as a measure of a location's socio-demographic development that takes into account average income per person, educational attainment, and total fertility rate. [34] [35] [36]

Reception

The results of the Global Burden of Disease Study have been cited by The New York Times , [37] The Washington Post , [38] Vox, [39] and The Atlantic . [40] [41]

The World Health Organization did not acknowledge the GBD 2010 estimates. [15] [16]

Publications

The following is a table of GBD publications as of October 2020. [42] [43] [44] [45] [46] [47]

"GBD 2010" proper means the paper was published as part of the original triple issue in The Lancet .

TitleCorresponding GBDPublication dateTypeVenue
"Latest global disease estimates reveal perfect storm of rising chronic diseases and public health failures fuelling COVID-19 pandemic"2019October 2020 Lancet
"The burden of mental disorders in the Eastern Mediterranean Region, 1990–2013"2013January 2017 PLOS ONE
"Global burden of hypertension and systolic blood pressure of at least 110 to 115 mmHg, 1990–2015"2015January 2017 JAMA
"The Global Burden of Disease study and the preventable burden of NCD"None (cites both 2010 and 2013)December 2016Global Heart
"Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 32 cancer groups, 1990 to 2015: a systematic analysis for the Global Burden of Disease study"2015December 2016 JAMA Oncology
"A subnational analysis of mortality and prevalence of COPD in China from 1990 to 2013"2013December 2016 Chest
"Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015"2015October 2016GBD 2015 proper The Lancet
"Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015"2015October 2016GBD 2015 proper The Lancet
"Global, regional, and national levels of maternal mortality, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015"2015October 2016GBD 2015 proper The Lancet
"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015"2015October 2016GBD 2015 proper The Lancet
"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015"2015October 2016GBD 2015 proper The Lancet
"Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015"2015October 2016GBD 2015 proper The Lancet
"Dissonant health transition in the states of Mexico, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013"2013October 2016 The Lancet
"Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease study 2015"2015September 2016 The Lancet
"Estimating the burden of disease attributable to injecting drug use as a risk factor for HIV, hepatitis C, and hepatitis B: findings from the Global Burden of Disease Study 2013"2013September 2016 The Lancet Infectious Diseases
"Health in times of uncertainty in the Eastern Mediterranean region, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013"2013August 2016 The Lancet Global Health
"Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013"2013August 2016 The BMJ
"Prevention of stroke: a strategic global imperative"2013July 2016 Nature Reviews Neurology
"Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015"2015July 2016 The Lancet HIV
"The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013"2013July 2016 The Lancet
"Global burden of stroke and risk factors in 188 countries, during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013"2013June 2016 The Lancet Neurology
"The burden of mental, neurological, and substance use disorders in China and India: a systematic analysis of community representative epidemiological studies"2013May 2016 The Lancet
"The global economic burden of dengue: a systematic analysis"2013April 2016 The Lancet Infectious Diseases
"The burden of cancer in Mexico, 1990–2013"2013March 2016 Salud Publica de Mexico
"Global burden of cutaneous leishmaniasis: a cross-sectional analysis from the Global Burden of Disease study 2013"2013February 2016 The Lancet Infectious Diseases
"The global burden of dengue: an analysis from the Global Burden of Disease study 2013"2013February 2016 The Lancet Infectious Diseases
"Global and national burden of diseases and injuries among children and adolescents between 1990 and 2013: Findings from the Global Burden of Disease 2013 study"2013January 2016 JAMA Pediatrics
"Stroke prevalence, mortality and disability-adjusted life years in children and youth aged 0–19 years: Data from the global and regional burden of stroke 2013"2013January 2016 Neuroepidemiology
"The global burden of injury: incidence, mortality, disability-adjusted life years and time trends from the Global Burden of Disease study 2013"2013December 2015 Injury Prevention
"Ambient air pollution exposure estimation for the Global Burden of Disease 2013"2013November 2015 Environmental Science & Technology
"Estimating distributions of health state severity for the Global Burden of Disease study"2013November 2015 Population Health Metrics
"Stroke prevalence, mortality and disability-adjusted life years in adults aged 20–64 years in 1990–2013: Data from the Global Burden of Disease 2013 study"2013October 2015 Neuroepidemiology
"Update on the global burden of ischemic and hemorrhagic stroke in 1990–2013: the GBD 2013 study"2013October 2015 Neuroepidemiology
"Atlas of the global burden of stroke (1990–2013): The GBD 2013 Study"2013October 2015 Neuroepidemiology
"Sex differences in stroke incidence, prevalence, mortality and disability-adjusted life years: Results from the Global Burden of Disease study 2013"2013October 2015 Neuroepidemiology
"Global and regional patterns in cardiovascular mortality from 1990 to 2013"2013October 2015 Circulation
"Cause-specific mortality for 240 causes in China during 1990–2013: a systematic subnational analysis for the Global Burden of Disease Study 2013"2013October 2015 The Lancet
"Under-5 mortality in 2,851 Chinese counties, 1996–2012: a subnational assessment of achieving MDG 4 goals in China"None (cites both 2010 and 2013)October 2015 The Lancet
"Disability weights for the Global Burden of Disease 2013 study"2013October 2015 The Lancet
"Methods for estimating the global burden of cerebrovascular diseases"2013October 2015 Neuroepidemiology
"Estimates of global and regional premature cardiovascular mortality in 2025"2013September 2015 Circulation
"Changes in health in England, with analysis by English regions and areas of deprivation, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013"2013September 2015 The Lancet
"Global, regional, and national comparative risk assessment of 79 behavioral, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013"2013September 2015 The Lancet
"Benchmarking health system performance across states in Nigeria: a systematic analysis of levels and trends in key maternal and child health interventions and outcomes, 2000–2013"2013September 2015 BMC Medicine
"Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition"2013August 2015 The Lancet
"Maintenance dialysis throughout the world in years 1990 and 2010"2010July 2015JASN
"Ischemic heart disease worldwide, 1990 to 2013"2013July 2015 Circulation: Cardiovascular Quality and Outcomes
"Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013"2013June 2015 The Lancet
"The Global Burden of Cancer 2013"2013May 2015 JAMA Oncology
"Demographic and epidemiologic drivers of global cardiovascular mortality"2013April 2015 The New England Journal of Medicine
"Mortality from cardiovascular diseases in sub-Saharan Africa, 1990–2013: a systematic analysis of data from the Global Burden of Disease study 2013: cardiovascular topic"2013April 2015 Cardiovascular Journal Africa
"Global burden of untreated caries: a systematic review and metaregression"2010March 2015 Journal of Dental Research
"Deconstructing the differences: a comparison of GBD 2010 and CHERG's approach to estimating the mortality burden of diarrhea, pneumonia, and their etiologies"2010January 2015 BMC Infectious Diseases
"Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013"2013December 2014 The Lancet
"The burden of disease in Spain: results from the Global Burden of Disease study 2010"2010December 2014 BioMed Central
"Global burden of severe periodontitis in 1990–2010: a systematic review and meta-regression"2010September 2014 Journal of Dental Research
"Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis"2010September 2014 BMC Medicine
"The Global Burden of Disease Study 2010: Interpretation and implications for the neglected tropical diseases"2010July 2014 PLOS Neglected Tropical Diseases
"Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013"2013July 2014 The Lancet
"Burden of injuries avertable by a basic surgical package in low- and middle-income regions: a systematic analysis from the Global Burden of Disease 2010 Study"2010July 2014 World Journal of Surgery
"Comparing cutaneous research funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases with 2010 Global Burden of Disease results"2010July 2014 PLOS ONE
"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013"2013May 2014 The Lancet
"Population health and burden of disease profile of Iran among 20 countries in the region: from Afghanistan to Qatar and Lebanon"2010May 2014 Archives of Iranian Medicine
"Evaluating causes of death and morbidity in Iran, Global Burden of Diseases, Injuries, and Risk Factors Study 2010"2010May 2014 Archives of Iranian Medicine
"Health transition in Iran toward chronic diseases based on results of Global Burden of Disease 2010"2010May 2014 Archives of Iranian Medicine
"Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013"2013May 2014 The Lancet
"Global, regional, and national levels and causes of maternal mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013"2013May 2014 The Lancet
"Temporal trends in ischemic heart disease mortality in 21 world regions, 1980–2010: the Global Burden of Disease 2010 Study"2010February 2014 Circulation
"The global burden of ischemic heart disease in 1990 and 2010: the Global Burden of Disease 2010 Study"2010February 2014 Circulation
"The state of health in the Arab world, 1990–2010: an analysis of the burden of diseases, injuries, and risk factors"2010January 2014 The Lancet
"Smoking prevalence and cigarette consumption in 187 countries, 1980–2012"2013January 2014 Journal of the American Medical Association
"Global, regional and national sodium intakes in 1990 and 2010: a systematic analysis of 24 h urinary sodium excretion and dietary surveys worldwide"2010December 2013 BMJ Open
"The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions"2010November 2013 Journal of Investigative Dermatology
"Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010"2010November 2013 The Lancet
"Burden of depressive disorders by country, sex, age, and year: findings from the Global Burden of Disease Study 2010"2010November 2013 PLoS Medicine
"Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990–2010: findings from the Global Burden of Disease Study 2010"2010October 2013 The Lancet
"A systematic analysis of global anemia burden from 1990 to 2010"2010October 2013 Blood
"Global burden of disease attributable to illicit drug use and dependence: findings from the Global Burden of Disease Study 2010"2010August 2013 The Lancet
"The burden of HIV: insights from the Global Burden of Disease Study 2010"2010August 2013 AIDS
"Measuring the Global Burden of Disease"2010August 2013 New England Journal of Medicine
"The state of US health, 1990–2010: burden of diseases, injuries, and risk factors"2010July 2013 Journal of the American Medical Association
"The global prevalence of intimate partner violence against women"None (does not seem to cite any GBD publication)June 2013 Science
"Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010"2010June 2013 The Lancet
"Global burden of oral conditions in 1990–2010: a systematic analysis"2010May 2013 Journal of Dental Research
"UK health performance: findings of the Global Burden of Disease Study 2010"2010March 2013 The Lancet
"Healthy life expectancy for 187 countries, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010"2010December 2012GBD 2010 proper The Lancet
"Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010"2010December 2012GBD 2010 proper The Lancet
"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010"2010December 2012GBD 2010 proper The Lancet
"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010"2010December 2012GBD 2010 proper The Lancet
"A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010"2010December 2012GBD 2010 proper The Lancet
"Years lived with disability (YLDs) for 1,160 sequelae of 289 diseases and injuries, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010"2010December 2012GBD 2010 proper The Lancet
"Age-specific and sex-specific mortality in 187 countries, 1970–2010: a systematic analysis for the Global Burden of Disease Study 2010"2010December 2012GBD 2010 proper The Lancet
"Global malaria mortality between 1980 and 2010: a systematic analysis"2010?February 2012 The Lancet
"National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5.4 million participants"NoneFebruary 2011 The Lancet
"The burden of injuries in Iranian children in 2005"NoneMarch 2010 Population Health Metrics
The Global Epidemiology of Infectious Diseases (GBD 1990 volume 4)19902004 World Health Organization
Health Dimensions of Sex and Reproduction: The Global Burden of Sexually Transmitted Diseases, HIV, Maternal Conditions, Perinatal Disorders, and Congenital Anomalies (GBD 1990 volume 3)19901998 Harvard School of Public Health [48]
Global Health Statistics: A Compendium of Incidence, Prevalence and Mortality Estimates for Over 200 Conditions (GBD 1990 volume 2)19901996 Harvard School of Public Health [49]
Global Burden of Disease: A comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020 (GBD 1990 volume 1)19901996 World Health Organization [50]

See also

Related Research Articles

<span class="mw-page-title-main">Cardiomyopathy</span> Disease of the heart muscle

Cardiomyopathy is a group of primary diseases of the heart muscle. Early on there may be few or no symptoms. As the disease worsens, shortness of breath, feeling tired, and swelling of the legs may occur, due to the onset of heart failure. An irregular heart beat and fainting may occur. Those affected are at an increased risk of sudden cardiac death.

<span class="mw-page-title-main">Upper respiratory tract infection</span> Medical condition

An upper respiratory tract infection (URTI) is an illness caused by an acute infection, which involves the upper respiratory tract, including the nose, sinuses, pharynx, larynx or trachea. This commonly includes nasal obstruction, sore throat, tonsillitis, pharyngitis, laryngitis, sinusitis, otitis media, and the common cold. Most infections are viral in nature, and in other instances, the cause is bacterial. URTIs can also be fungal or helminthic in origin, but these are less common.

<span class="mw-page-title-main">Congenital heart defect</span> Defect in the structure of the heart that is present at birth

A congenital heart defect (CHD), also known as a congenital heart anomaly, congenital cardiovascular malformation, and congenital heart disease, is a defect in the structure of the heart or great vessels that is present at birth. A congenital heart defect is classed as a cardiovascular disease. Signs and symptoms depend on the specific type of defect. Symptoms can vary from none to life-threatening. When present, symptoms are variable and may include rapid breathing, bluish skin (cyanosis), poor weight gain, and feeling tired. CHD does not cause chest pain. Most congenital heart defects are not associated with other diseases. A complication of CHD is heart failure.

<span class="mw-page-title-main">Lower respiratory tract infection</span> Medical term

Lower respiratory tract infection (LRTI) is a term often used as a synonym for pneumonia but can also be applied to other types of infection including lung abscess and acute bronchitis. Symptoms include shortness of breath, weakness, fever, coughing and fatigue. A routine chest X-ray is not always necessary for people who have symptoms of a lower respiratory tract infection.

<span class="mw-page-title-main">Obstructed labour</span> Medical condition

Obstructed labour, also known as labour dystocia, is the baby not exiting the pelvis because it is physically blocked during childbirth although the uterus contracts normally. Complications for the baby include not getting enough oxygen which may result in death. It increases the risk of the mother getting an infection, having uterine rupture, or having post-partum bleeding. Long-term complications for the mother include obstetrical fistula. Obstructed labour is said to result in prolonged labour, when the active phase of labour is longer than 12 hours.

<span class="mw-page-title-main">Global health</span> Health of populations in a global context

Global health is the health of the populations in the worldwide context; it has been defined as "the area of study, research, and practice that places a priority on improving health and achieving equity in health for all people worldwide". Problems that transcend national borders or have a global political and economic impact are often emphasized. Thus, global health is about worldwide health improvement, reduction of disparities, and protection against global threats that disregard national borders, including the most common causes of human death and years of life lost from a global perspective.

<span class="mw-page-title-main">Hypertensive heart disease</span> Medical condition

Hypertensive heart disease includes a number of complications of high blood pressure that affect the heart. While there are several definitions of hypertensive heart disease in the medical literature, the term is most widely used in the context of the International Classification of Diseases (ICD) coding categories. The definition includes heart failure and other cardiac complications of hypertension when a causal relationship between the heart disease and hypertension is stated or implied on the death certificate. In 2013 hypertensive heart disease resulted in 1.07 million deaths as compared with 630,000 deaths in 1990.

<span class="mw-page-title-main">Paratyphoid fever</span> Bacterial infection caused by one of the three types of Salmonella enterica

Paratyphoid fever, also known simply as paratyphoid, is a bacterial infection caused by one of three types of Salmonella enterica. Symptoms usually begin 6–30 days after exposure and are the same as those of typhoid fever. Often, a gradual onset of a high fever occurs over several days. Weakness, loss of appetite, and headaches also commonly occur. Some people develop a skin rash with rose-colored spots. Without treatment, symptoms may last weeks or months. Other people may carry the bacteria without being affected; however, they are still able to spread the disease to others. Typhoid and paratyphoid are of similar severity. Paratyphoid and typhoid fever are types of enteric fever.

<span class="mw-page-title-main">Disability-adjusted life year</span> Measure of disease burden

Disability-adjusted life years (DALYs) are a measure of overall disease burden, expressed as the number of years lost due to ill-health, disability, or early death. It was developed in the 1990s as a way of comparing the overall health and life expectancy of different countries.

<span class="mw-page-title-main">Perinatal mortality</span> Medical condition

Perinatal mortality (PNM) is the death of a fetus or neonate and is the basis to calculate the perinatal mortality rate. Perinatal means "relating to the period starting a few weeks before birth and including the birth and a few weeks after birth."

<span class="mw-page-title-main">Acute proliferative glomerulonephritis</span> Medical condition

Acute proliferative glomerulonephritis is a disorder of the small blood vessels of the kidney. It is a common complication of bacterial infections, typically skin infection by Streptococcus bacteria types 12, 4 and 1 (impetigo) but also after streptococcal pharyngitis, for which it is also known as postinfectious glomerulonephritis (PIGN) or poststreptococcal glomerulonephritis (PSGN). It can be a risk factor for future albuminuria. In adults, the signs and symptoms of infection may still be present at the time when the kidney problems develop, and the terms infection-related glomerulonephritis or bacterial infection-related glomerulonephritis are also used. Acute glomerulonephritis resulted in 19,000 deaths in 2013, down from 24,000 deaths in 1990 worldwide.

<span class="mw-page-title-main">Disease burden</span> Impact of diseases

Disease burden is the impact of a health problem as measured by financial cost, mortality, morbidity, or other indicators. It is often quantified in terms of quality-adjusted life years (QALYs) or disability-adjusted life years (DALYs). Both of these metrics quantify the number of years lost due to disability (YLDs), sometimes also known as years lost due to disease or years lived with disability/disease. One DALY can be thought of as one year of healthy life lost, and the overall disease burden can be thought of as a measure of the gap between current health status and the ideal health status. According to an article published in The Lancet in June 2015, low back pain and major depressive disorder were among the top ten causes of YLDs and were the cause of more health loss than diabetes, chronic obstructive pulmonary disease, and asthma combined. The study based on data from 188 countries, considered to be the largest and most detailed analysis to quantify levels, patterns, and trends in ill health and disability, concluded that "the proportion of disability-adjusted life years due to YLDs increased globally from 21.1% in 1990 to 31.2% in 2013." The environmental burden of disease is defined as the number of DALYs that can be attributed to environmental factors. Similarly, the work-related burden of disease is defined as the number of deaths and DALYs that can be attributed to occupational risk factors to human health. These measures allow for comparison of disease burdens, and have also been used to forecast the possible impacts of health interventions. By 2014, DALYs per head were "40% higher in low-income and middle-income regions."

<span class="mw-page-title-main">Health in Tajikistan</span> Overview of health in Tajikistan

The Tajikistan health system is influenced by the former Soviet legacy. It is ranked as the poorest country within the WHO European region, including the lowest total health expenditure per capita. Tajikistan is ranked 129th as Human Development Index of 188 countries, with an Index of 0.627 in 2016. In 2016, the SDG Index value was 56. In Tajikistan health indicators such as infant and maternal mortality rates are among the highest of the former Soviet republics. In the post-Soviet era, life expectancy has decreased because of poor nutrition, polluted water supplies, and increased incidence of cholera, malaria, tuberculosis, and typhoid. Because the health care system has deteriorated badly and receives insufficient funding and because sanitation and water supply systems are in declining condition, Tajikistan has a high risk of epidemic disease.

<span class="mw-page-title-main">Falling (accident)</span> Cause of injury or death

Falling is the action of a person or animal losing stability and ending up in a lower position, often on the ground. It is the second-leading cause of accidental death worldwide and a major cause of personal injury, especially for the elderly. Falls in older adults are a major class of preventable injuries. Construction workers, electricians, miners, and painters are occupations with high rates of fall injuries.

<span class="mw-page-title-main">Christopher J. L. Murray</span> American global health researcher (born 1962)

Christopher J. L. Murray is an American physician, health economist, and global health researcher. He is a professor at the University of Washington in Seattle, where he is Chair of Health Metrics Science and the director of the Institute for Health Metrics and Evaluation (IHME).

<span class="mw-page-title-main">Institute for Health Metrics and Evaluation</span> Statistics institute for public health under the University of Washington, based in Seattle

The Institute for Health Metrics and Evaluation (IHME) is a national and international public health agency and research institute working in the area of global health statistics and impact evaluation, located at the University of Washington in Seattle. IHME is headed by Christopher J.L. Murray, a physician, health economist, and global health researcher, and professor at the University of Washington Department of Global Health, which is part of the School of Medicine. IHME conducts research and trains scientists, policymakers, and the public in health metrics concepts, methods, and tools. Its mission includes judging the effectiveness and efficacy of health initiatives and national health systems. IHME also trains students at the post-baccalaureate and post-graduate levels.

Dean Tecumseh Jamison is an American economist and leader in the study of global health. He is currently Senior Fellow in Global Health Sciences at University of California, San Francisco and an Emeritus Professor of Global Health at the University of Washington in Seattle. He has published in health economics, global health, education economics, and decision theory.

Lidia Morawska is a Polish–Australian physicist and distinguished professor at the School of Earth and Atmospheric Sciences, at the Queensland University of Technology and director of the International Laboratory for Air Quality and Health (ILAQH) at QUT. She is also co-director of the Australia-China Centre for Air Quality Science and Management, an adjunct professor at the Jinan University in China, and a Vice-Chancellor fellow at the Global Centre for Clean Air Research (GCARE), University of Surrey in the United Kingdom. Her work focuses on fundamental and applied research in the interdisciplinary field of air quality and its impact on human health, with a specific focus on atmospheric fine, ultrafine and nanoparticles. Since 2003, she expanded her interests to include also particles from human respiration activities and airborne infection transmission.

<span class="mw-page-title-main">Rita Krishnamurthi</span> Epidemiologist in New Zealand

Rita V. Krishnamurthi is a New Zealand academic, and since 2023 is a full professor at the Auckland University of Technology, specialising in the epidemiology of stroke and dementia.

References

  1. "About GBD". 18 April 2014.
  2. "What does a $100 million public health data revolution look like?". TEDMED.
  3. 1 2 3 "Institute for Health Metrics and Evaluation and World Health Organization sign new agreement" . Institute for Health Metrics and Evaluation. May 2015. Retrieved January 29, 2017.
  4. Prüss-Üstün A, Mathers C, Corvalán C, Woodward A (2003). Assessing the environmental burden of disease at national and local levels: Introduction and methods. WHO Environmental Burden of Disease Series. Vol. 1. Geneva: World Health Organization. ISBN   978-92-4-154620-1. Archived from the original on June 12, 2005.
  5. 1 2 3 4 "About the Global Burden of Disease (GBD) project". Health statistics and health information systems. World Health Organization. Archived from the original on October 27, 2008.
  6. "Global burden of disease". World Health Organization.
  7. "The global burden of disease: 2004 update" (PDF). World Health Organization. 2008.
  8. "Global health risks: mortality and burden of disease attributable to selected major risks" (PDF). World Health Organization. 2009.
  9. Global Burden of Disease (GBD) at WHO, 2012
  10. "Global Burden of Disease: Massive shifts reshape the health landscape worldwide". Institute for Health Metrics and Evaluation. 2014-05-08. Retrieved January 30, 2017. That's one of the main findings from the Global Burden of Disease Study 2010 (GBD 2010), a collaborative project led by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington.
  11. 1 2 3 "History". Institute for Health Metrics and Evaluation. 2014-05-10. Retrieved January 29, 2017.
  12. Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. (2013). "Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010". Lancet. 380 (9859): 2197–223. doi:10.1016/S0140-6736(12)61689-4. PMID   23245608. S2CID   205967479.
  13. 1 2 Murray CJ, Ezzati M, Flaxman AD, Lim S, Lozano R, Michaud C, et al. (2013). "GBD 2010: design, definitions, and metrics". Lancet. 380 (9859): 2063–6. doi:10.1016/S0140-6736(12)61899-6. PMID   23245602. S2CID   27164993.
  14. Watts C, Cairncross S (2013). "Should the GBD risk factor rankings be used to guide policy?". Lancet. 380 (9859): 2060–1. doi:10.1016/S0140-6736(12)62121-7. PMID   23245600. S2CID   40347192.
  15. 1 2 Rudan I, Chan KY (December 18, 2014). "Global health metrics needs collaboration and competition" (PDF). The Lancet . 385 (9963): 92–94. doi:10.1016/S0140-6736(14)62006-7. PMID   25530441. S2CID   28100116 . Retrieved January 27, 2017.
  16. 1 2 Doughton S (January 25, 2017). "Historic gift: Gates Foundation gives $279 million to University of Washington". The Seattle Times . Retrieved January 25, 2017. Initially, though, IHME antagonized other health experts, who accused the Seattle institute of arrogance and failing to share data and methods. Its first global health report card was not acknowledged by the World Health Organization.
  17. 1 2 3 4 5 6 7 GBD 2013 Mortality and Causes of Death Collaborators (2014). "Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013". The Lancet. 385 (9963): 117–171. doi:10.1016/S0140-6736(14)61682-2. ISSN   0140-6736. PMC   4340604 . PMID   25530442.{{cite journal}}: |author1= has generic name (help)CS1 maint: numeric names: authors list (link)
  18. "GBD History". Institute for Health Metrics and Evaluation. 2014-04-18. Retrieved January 30, 2017.
  19. 1 2 "History". Institute for Health Metrics and Evaluation. 2014-05-09. Retrieved 2020-12-26.
  20. "Epic Measures". jeremynsmith.com. Retrieved 2020-12-26.
  21. 1 2 "Latest GBD results: 2019". IHME. University of Washington. 8 October 2020. Retrieved 9 July 2022.
  22. 1 2 "Latest GBD results: 2021". TheLancet. Elsevier. 25 May 2024. Retrieved 25 May 2024.
  23. "GBD Fact Sheets". IHME. University of Washington. 25 May 2024. Retrieved 25 May 2024.
  24. "GBD Results Tool". IHME. University of Washington. 25 May 2024. Retrieved 25 May 2024.
  25. Brown D (March 5, 2013). "Web-based tool charts disease, risk factors around the world and through time". The Washington Post . Retrieved January 31, 2017.
  26. Das P (2012). "The story of GBD 2010: a "super human" effort". Lancet. 380 (9859): 2067–2070. doi: 10.1016/s0140-6736(12)62174-6 . PMID   23259158. S2CID   45801452.
  27. "Increase in global life expectancy offset by war, obesity, and substance abuse". Institute for Health Metrics and Evaluation. 2016-10-03. Archived from the original on 2017-01-25. Retrieved January 29, 2017.
  28. GBD 2015 Mortality and Causes of Death Collaborators (2016-10-08). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015". The Lancet. 388 (10053): 1459–1544. doi:10.1016/S0140-6736(16)31012-1. ISSN   0140-6736. PMC   5388903 . PMID   27733281.
  29. "Global burden of disease study 2015 assesses the state of the world's health". ScienceDaily . October 6, 2016. Retrieved January 29, 2017.
  30. Peter Hotez (November 17, 2016). "Vaccinations, Vaccine Science, and a New US President | Speaking of Medicine". PLOS . Retrieved January 31, 2017. Those results include new findings just released by the Gates Foundation-supported Global Burden of Disease 2015 Mortality and Causes of Death Collaborators that found a 75 percent reduction in global measles mortality over the last decade such that (for the first time ever) fewer than 100,000 children died from measles in 2013 and 2015
  31. "Table 3: Selected causes of global child deaths in 1990 and 2013" . Retrieved January 31, 2017.
  32. "Table 5: Global deaths in 2005 and 2015 for all ages and both sexes combined and age-standardised death rates, with percentage change between 2005 and 2015 for 249 causes" . Retrieved January 31, 2017.
  33. Nisha Gaind (July 25, 2016). "Global rate of new HIV infections hasn't fallen in a decade". Nature. doi:10.1038/nature.2016.20305. S2CID   78940073 . Retrieved February 2, 2017.
  34. "Global Burden of Disease Study 2015 (GBD 2015) Socio-Demographic Index (SDI) 1980–2015". GHDx. Institute for Health Metrics and Evaluation . Retrieved February 7, 2017.
  35. Myers J (September 23, 2016). "There's a new ranking of the healthiest countries. How is yours doing?". World Economic Forum . Retrieved February 7, 2017.
  36. Lancet T (2016-10-08). "GBD 2015: from big data to meaningful change". The Lancet. 388 (10053): 1447. doi:10.1016/S0140-6736(16)31790-1. ISSN   0140-6736. PMID   27733277. S2CID   33167967 . Retrieved 2017-02-07.
  37. Edward Wong (August 17, 2016). "Coal Burning Causes the Most Air Pollution Deaths in China, Study Finds". The New York Times . Retrieved January 31, 2017.
  38. "Roads Kill: The toll of traffic accidents is rising in poor countries". The Washington Post . January 13, 2014. Retrieved January 31, 2017.
  39. Dylan Matthews (March 13, 2015). "The #1 reason people die early, in each country". Vox. Retrieved January 31, 2017.
  40. Neal Emery (January 24, 2013). "How the World Gets Sick and Dies". The Atlantic . Retrieved January 31, 2017.
  41. Olga Khazan (October 7, 2016). "How Back Pain Took Over the World". The Atlantic . Retrieved January 31, 2017.
  42. "Global Burden of Disease (GBD 2019)". Institute for Health Metrics and Evaluation. 2014-03-17. Retrieved 2020-12-26.
  43. "Research Articles – Project: Global Burden of Diseases, Injuries, and Risk Factors Study (GBD)". Institute for Health Metrics and Evaluation . Retrieved February 2, 2017.
  44. "Lancet Global Burden of Disease". The Lancet . Retrieved February 3, 2017.
  45. "Lancet Global Burden of Disease Study 2013". The Lancet . Retrieved February 3, 2017.
  46. "Lancet Global Burden of Disease Study 2010". The Lancet . Retrieved February 3, 2017.
  47. Murray CJ, Lopez AD. "Search Results for: The Global Burden of Disease and Injury". Harvard University Press. Retrieved February 3, 2017.
  48. Christopher J. L. Murray, Alan D. Lopez, eds. (1998). Health dimensions of sex and reproduction: the global burden of sexually transmitted diseases, HIV, maternal conditions, perinatal disorders, and congenital anomalies. World Health Organization. hdl:10665/42161. ISBN   0-674-38335-4.
  49. Christopher J. L. Murray, Alan D. Lopez (1996). Global health statistics: a compendium of incidence, prevalence and mortality estimates for over 200 conditions. World Health Organization. hdl:10665/41848. ISBN   0-674-35449-4.
  50. Christopher J. L. Murray, Alan D. Lopez, eds. (1996). WHO IRIS: The Global burden of disease : a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020: summary. World Health Organization. hdl: 10665/41864 . ISBN   0-9655466-0-8.