DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene. [5]
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. [6]
MCM3 has been shown to interact with:
DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.
Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively. With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates ; phosphorylation of these proteins leads to cell cycle progression.
Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.
DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.
DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.
Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.
DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.
Cell cycle checkpoint protein RAD1 is a protein that in humans is encoded by the RAD1 gene.
CDT1 is a protein that in humans is encoded by the CDT1 gene. It is a licensing factor that functions to limit DNA from replicating more than once per cell cycle.
Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.
DNA replication licensing factor MCM5 is a protein that in humans is encoded by the MCM5 gene.
Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conserved throughout eukaryotic evolution; this means that most eukaryotic cells have the Cdc7 kinase protein.
Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.
Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.
Protein MCM10 homolog is a protein that in humans is encoded by the MCM10 gene. It is essential for activation of the Cdc45:Mcm2-7:GINS helicase, and thus required for proper DNA replication.
CDC45 is a protein that in humans is encoded by the CDC45L gene.
80 kDa MCM3-associated protein is a protein that in humans is encoded by the MCM3AP gene.
Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.
Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.
Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein in archaea.