Philippe B. Wilson | |
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Alma mater | University of Bath |
Scientific career | |
Institutions | University of Bath De Montfort University Nottingham Trent University National Health Service |
Thesis | Towards Isotope Effect Calculations in the Supramolecular Age (2016) |
Philippe B. Wilson is a Franco-British healthcare scientist who is Professor of One Health at Nottingham Trent University. Since 2021, he has served as Chief Scientific Officer of NHS Willows Health. His research considers the development of tools and technologies for translational medicine with applications to human, environmental and animal health. He was named by Forbes Magazine in their 2018 30 under 30 Listing for his work in Healthcare and Medicine.
Wilson undertook his secondary education at Churchill Academy and Sixth Form. He was an undergraduate student in chemistry at the University of Bath. [1] He remained at The University of Bath for his doctoral research. [2]
Wilson moved to De Montfort University as an Early Career Academic Fellow in Clinical Chemistry. [3] He became an associate professor at De Montfort University in 2019. [4] There, he worked on nuclear magnetic resonance technologies in point of care applications.
In 2020, Wilson moved to a position as Scientific Director and Head of Conservation of the Rare Breeds Survival Trust in order to support the growing academic activities of the organisation. [5] Same year, he took up the position of chair and Professor of One Health at Nottingham Trent University within the School of Animal, Rural and Environmental Sciences and the Medical Technologies Innovation Facility.[ citation needed ]
During the COVID-19 pandemic in 2020, Wilson was appointed as Chief Scientific Officer of NHS Willows Health, a National Health Service Primary Care Network. He led the Clinical Trial Unit and achieved First Global Patient In for AstraZeneca's TACKLE monoclonal antibody clinical trial. [6]
Wilson's research now focusses on One Health. [7] He has studied biosensors, including benchtop nuclear magnetic resonance devices and nitrogen-vacancy centers for quantum sensing. [1] [8] He chairs the Royal Society of Biology East Midlands Branch, and is appointed to the UK Genetics of Livestock and Equines Committee within the Department for Food, Environment and Rural Affairs in UK Government, [9] and the Committee on the Toxicity of Chemicals in Food, Consumer Products and the Environment at Public Health England and the Food Standards Agency. [10] In 2022 he was elected to the Comparative Medicine Council of the Royal Society of Medicine. [11] He is a Fellow of the Royal Society of Biology, Fellow of the Royal Society of Medicine and a Fellow of the Linnean Society of London.
Wilson has a background in agriculture from a young age. [2] He was a Trustee of the Poultry Club of Great Britain from 2017 to 2022 where he served in a number of roles including Chairing the Poultry and Eggs Committee of the Charity. [16] He has also served as a Panel B Judge for the Charity. [17]
Self‐Assembled Anion‐Binding Cryptand for the Selective Liquid–Liquid Extraction of Phosphate Anions [18]
Benchtop Low-Frequency 60 MHz NMR Analysis of Urine: A Comparative Metabolomics Investigation [19]
Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models [20]
Preliminary demonstration of benchtop NMR metabolic profiling of feline urine: chronic kidney disease as a case study [21]
16 Years of breed management brings substantial improvement in population genetics of the endangered Cleveland Bay Horse [22]
Clinical chemistry is a division in medical laboratory sciences focusing on qualitative tests of important compounds, referred to as analytes or markers, in bodily fluids and tissues using analytical techniques and specialized instruments. This interdisciplinary field includes knowledge from medicine, biology, chemistry, biomedical engineering, informatics, and an applied form of biochemistry.
Proteinuria is the presence of excess proteins in the urine. In healthy persons, urine contains very little protein, less than 150 mg/day; an excess is suggestive of illness. Excess protein in the urine often causes the urine to become foamy. Severe proteinuria can cause nephrotic syndrome in which there is worsening swelling of the body.
Isoflurane, sold under the brand name Forane among others, is a general anesthetic. It can be used to start or maintain anesthesia; however, other medications are often used to start anesthesia, due to airway irritation with isoflurane. Isoflurane is given via inhalation.
Dimethylmercury is an extremely toxic organomercury compound with the formula (CH3)2Hg. A volatile, flammable, dense and colorless liquid, dimethylmercury is one of the strongest known neurotoxins. Less than 0.1 mL is capable of inducing severe mercury poisoning resulting in death.
Liver disease, or hepatic disease, is any of many diseases of the liver. If long-lasting it is termed chronic liver disease. Although the diseases differ in detail, liver diseases often have features in common.
Metabolomics is the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Specifically, metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind", the study of their small-molecule metabolite profiles. The metabolome represents the complete set of metabolites in a biological cell, tissue, organ, or organism, which are the end products of cellular processes. Messenger RNA (mRNA), gene expression data, and proteomic analyses reveal the set of gene products being produced in the cell, data that represents one aspect of cellular function. Conversely, metabolic profiling can give an instantaneous snapshot of the physiology of that cell, and thus, metabolomics provides a direct "functional readout of the physiological state" of an organism. There are indeed quantifiable correlations between the metabolome and the other cellular ensembles, which can be used to predict metabolite abundances in biological samples from, for example mRNA abundances. One of the ultimate challenges of systems biology is to integrate metabolomics with all other -omics information to provide a better understanding of cellular biology.
The metabolome refers to the complete set of small-molecule chemicals found within a biological sample. The biological sample can be a cell, a cellular organelle, an organ, a tissue, a tissue extract, a biofluid or an entire organism. The small molecule chemicals found in a given metabolome may include both endogenous metabolites that are naturally produced by an organism as well as exogenous chemicals that are not naturally produced by an organism.
Metabolic acidosis is a serious electrolyte disorder characterized by an imbalance in the body's acid-base balance. Metabolic acidosis has three main root causes: increased acid production, loss of bicarbonate, and a reduced ability of the kidneys to excrete excess acids. Metabolic acidosis can lead to acidemia, which is defined as arterial blood pH that is lower than 7.35. Acidemia and acidosis are not mutually exclusive – pH and hydrogen ion concentrations also depend on the coexistence of other acid-base disorders; therefore, pH levels in people with metabolic acidosis can range from low to high.
Penicillamine, sold under the brand name of Cuprimine among others, is a medication primarily used for the treatment of Wilson's disease. It is also used for people with kidney stones who have high urine cystine levels, rheumatoid arthritis, and various heavy metal poisonings. It is taken by mouth.
The anion gap is a value calculated from the results of multiple individual medical lab tests. It may be reported with the results of an electrolyte panel, which is often performed as part of a comprehensive metabolic panel.
[18F]Fluorodeoxyglucose (INN), or fluorodeoxyglucose F 18, also commonly called fluorodeoxyglucose and abbreviated [18F]FDG, 2-[18F]FDG or FDG, is a radiopharmaceutical, specifically a radiotracer, used in the medical imaging modality positron emission tomography (PET). Chemically, it is 2-deoxy-2-[18F]fluoro-D-glucose, a glucose analog, with the positron-emitting radionuclide fluorine-18 substituted for the normal hydroxyl group at the C-2 position in the glucose molecule.
Renal tubular acidosis (RTA) is a medical condition that involves an accumulation of acid in the body due to a failure of the kidneys to appropriately acidify the urine. In renal physiology, when blood is filtered by the kidney, the filtrate passes through the tubules of the nephron, allowing for exchange of salts, acid equivalents, and other solutes before it drains into the bladder as urine. The metabolic acidosis that results from RTA may be caused either by insufficient secretion of hydrogen ions into the latter portions of the nephron or by failure to reabsorb sufficient bicarbonate ions from the filtrate in the early portion of the nephron. Although a metabolic acidosis also occurs in those with chronic kidney disease, the term RTA is reserved for individuals with poor urinary acidification in otherwise well-functioning kidneys. Several different types of RTA exist, which all have different syndromes and different causes. RTA is usually an incidental finding based on routine blood draws that show abnormal results. Clinically, patients may present with vague symptoms such as dehydration, mental status changes, or delayed growth in adolescents.
Pharmacometabolomics, also known as pharmacometabonomics, is a field which stems from metabolomics, the quantification and analysis of metabolites produced by the body. It refers to the direct measurement of metabolites in an individual's bodily fluids, in order to predict or evaluate the metabolism of pharmaceutical compounds, and to better understand the pharmacokinetic profile of a drug. Alternatively, pharmacometabolomics can be applied to measure metabolite levels following the administration of a pharmaceutical compound, in order to monitor the effects of the compound on certain metabolic pathways(pharmacodynamics). This provides detailed mapping of drug effects on metabolism and the pathways that are implicated in mechanism of variation of response to treatment. In addition, the metabolic profile of an individual at baseline (metabotype) provides information about how individuals respond to treatment and highlights heterogeneity within a disease state. All three approaches require the quantification of metabolites found in bodily fluids and tissue, such as blood or urine, and can be used in the assessment of pharmaceutical treatment options for numerous disease states.
Camel urine is a liquid by-product of metabolism in a camel's anatomy. Urine from camels has been used in prophetic medicine for centuries, being a part of ancient Bedouin practices and also Muslim tradition. According to the World Health Organization, the use of camel urine as a traditional medicine lacks scientific evidence.
Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body becoming unresponsive to the hormone's effects. Classic symptoms include thirst, polyuria, weight loss, and blurred vision. If left untreated, the disease can lead to various health complications, including disorders of the cardiovascular system, eye, kidney, and nerves. Untreated or poorly treated diabetes accounts for approximately 1.5 million deaths every year.
David S. Wishart is a Canadian researcher and a Distinguished University Professor in the Department of Biological Sciences and the Department of Computing Science at the University of Alberta. Wishart also holds cross appointments in the Faculty of Pharmacy and Pharmaceutical Sciences and the Department of Laboratory Medicine and Pathology in the Faculty of Medicine and Dentistry. Additionally, Wishart holds a joint appointment in metabolomics at the Pacific Northwest National Laboratory in Richland, Washington. Wishart is well known for his pioneering contributions to the fields of protein NMR spectroscopy, bioinformatics, cheminformatics and metabolomics. In 2011, Wishart founded the Metabolomics Innovation Centre (TMIC), which is Canada's national metabolomics laboratory.
Melissa Louise Mather is an Australian physicist who is Professor in Biological Sensing and Imaging at the University of Nottingham. Her research considers the development of novel sensing techniques, including ultrasound, single molecule imaging and nitrogen-vacancy centers in diamond.
Rachel Louise Batterham is a British physician who is a professor of Obesity, Diabetes and Endocrinology at University College London. She established the University College London Hospitals NHS Foundation Trust Bariatric Centre for Weight Management and Metabolic Surgery. She has extensively studied obesity, and has contributed to clinical management and the understanding of obesity-related diseases.
Makoto Furutani-Seiki is a Japanese molecular biologist who is a Professor of Systems Biochemistry in the School of Medicine at Yamaguchi University, Japan.
Alkali citrate is an inhibitor of kidney stones. It is used to increase urine citrate levels - this prevents calcium oxalate stones by binding to calcium and inhibiting its binding to oxalate. It is also used to increase urine pH - this prevents uric acid stones and cystine stones.