Amira Abdelrasoul

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Amira Abdelrasoul
Amira Abdelrasoul.jpg
Alma mater
Scientific career
Fields
Institutions University of Saskatchewan

Amira Abdelrasoul is a researcher and associate professor at the Department of Chemical and Biological Engineering at the University of Saskatchewan, where she is the principal investigator of the Hemodialysis Membrane Science and Nanotechnology Research Centre. [1] She is also a membrane technology leader in Canada, and her interdisciplinary research program focuses on solving existing hemodialysis system problems. [2]

Contents

Early years and education

Amira Abdelrasoul received her Bachelor of Science in Chemical Engineering from Alexandria University, Egypt. She then completed a Master of Science from Kuwait University, Kuwait, and went on to receive her PhD from Ryerson University (currently Toronto Metropolitan University), Canada, where she completed postdoctoral research. She is also a licensed professional engineer at Professional Engineers of Ontario (PEO) and Association of Professional Engineers and Geoscientists of Saskatchewan (APEGS).

Career

Abdelrasoul started her career as a research assistant at the American Engineering Consultants ARAMCO in 2000. She joined Kuwait Polyurethane Industry as a R&D polymer process engineer in 2002. Later, she served as a research and teaching assistant at the Department of Chemical Engineering at the College of Engineering and Petroleum, Kuwait, from 2005 to 2008. During this time, she joined Kuwait Institute for Scientific Research as a research assistant in 2006. In 2008, she started working as a product development engineer at J Composites Inc, Canada.

Abdelrasoul became a teaching assistant at Ryerson University in 2011 while simultaneously pursuing a PhD. In 2015, she got promoted to the position of lecturer at the Department of Chemical Engineering at Ryerson, where she was also a postdoctoral research associate.

In 2017, Abdelrasoul joined the University of Saskatchewan's chemical and biological engineering department as an assistant professor and was promoted to associate professor in July 2022. [2]  She is the principal investigator of the Hemodialysis Membrane Science and Nanotechnology Research Centre at the University of Saskatchewan. [1]

In 2019, she was an early career investigator in the Canadian Institutes of Health Research (CIHR) Peer Review Committee for the Project Grant Competition. [3] In 2020, Abdelrasoul co-chaired the Exploration Multidisciplinary Review Panel of New Frontiers in Research Fund (NFRF) of Social Sciences and Humanities Research Council. [4] [5]

Abdelrasoul is also an associate member of numerous educational and research institutes, including the Biomedical Engineering Division at University of Saskatchewan, [6] Global Institute for Water Security at the University of Saskatchewan, [7] Gwenna Moss Centre for Teaching and Learning at the University of Saskatchewan, [8] Yeates School of Graduate Studies at the Toronto Metropolitan University, and the Kidney Health and Disease (M3K) Committee. In addition she is a member of M3K Organizing Committee for the second pan-Canadian Molecules and Mechanisms Mediating Kidney Health and Disease (M3K) Meeting in Montreal, Canada in 2023. [9]

Since 2018, Abdelrasoul has been a part of the Membrane Technology Design Projects Client at the University of Toronto for Engineering Strategies and Practice Course (ESP) APS112 and APS113. She joined Scientific Reports as an editorial board member in 2022.

Abdelrasoul also achieved a teaching portfolio with a University Teaching Development Professional Program (UTDP) accredited by SEDA (Staff and Educational Development Association) in the United Kingdom. She is a licensed Instructional Skills and Educational Development Facilitator and a Fellow of the Staff and Educational Development Association (FSEDA). [2]

She has launched the Women in Engineering (WIE) chapter in the Chemical and Biological Engineering Department at the University of Saskatchewan, and she has been the WIE chair since 2018 to support and lead WIE undergraduate and graduate students; to support equity, diversity, and inclusion; and to mentor female student to build skills and reach crucial milestones. [10]

Hemodialysis membrane research

At University of Saskatchewan, Abdelrasoul initiated and incepted the first hemodialysis membrane research program in Canada. Her interdisciplinary research program focuses on solving existing hemodialysis problems, decreasing morbidity and mortality rates of hemodialysis patients, increasing the quality of life of kidney failure patients, and decreasing the high costs to the healthcare system in Canada and beyond that are normally attributed to hemodialysis and its shortcomings. Abdelrasoul was on the top list of the first NFRF competition of 2018 exploration for her interdisciplinary, international, high-risk/high-reward and fast-breaking research funded by the Social Sciences and Humanities Research Council. [11]

Abdelrasoul has pioneered the use of customized gold nanoparticles to label and track the movement of specific blood proteins through hemodialysis membranes, which has proven to be a significant advance towards achieving more biocompatible dialysis membranes. The work she has done has led to groundbreaking advances in hemodialysis membrane science and technology.  For example, one recent study was the first to be able to predict the inflammation that patients may experience after a dialysis session.  With the new information she has gathered through her work at CLS, she is now able to create new designs and membrane materials to be tested in dialysis applications. Abdelrasoul's research program progress was recently[ when? ] featured in The Conversation Canada.[ citation needed ] She has been interviewed by CTV Your Morning [12] and CTV News. [13] In 2022, she was invited to deliver a lecture on the life/ nephrology campus in Germany. [14]

She is an active member of the Saskatchewan Centre for Patient-Oriented Research (SCPOR). She is working with dialysis patients and conducting targeted knowledge mobilization initiatives to facilitate sharing of the findings of her research program in non-academic mediums and with stakeholders. This work is partially funded by the Saskatchewan Health Research Foundation (SHRF) to further develop research directions toward patient outcomes. [15] [16]

Her team was the first in Canada to conduct in-depth studies of the chemical and physical characteristics of hemodialysis membranes used in Canadian hospitals. [17] [18] Her team also worked on modeling membrane characteristics and clinical practices to predict inflammation in dialysis patients. This work is now expanding to consider how different membranes and practices affect patients of different sexes, genders, and races, and with different medical histories. [19] Abdelrasoul is working on synthesizing new and improved hemodialysis membranes. This direction will lead to new membranes that are more compatible with patient blood, and thus will enhance their quality of life and address a critical health and economic problem in Canada. [20] [21] [22]

Her team has developed a theoretical model using computer simulations of molecule interactions to gain insight the interaction between blood proteins and the HD membranes currently used in hospitals. [17] [23] Abdelrasoul's recent[ when? ] work at the CLS has led to groundbreaking advances in HD membrane science and technology. For the first time, her research has directly linked the characteristics of the commercial membranes used in Canada to patient side effects. [17] [24] [25]

App for dialysis patients

Abdelrasoul worked with Push Interactions and funding from the Saskatchewan Health Research Foundation to develop an app through which dialysis patients can share their experiences. [26]

Publications

Articles

Abdelrasoul has authored and co-authored numerous research articles. [27] [28]

Books

She authored Biomimetic and Bioinspired Membranes for New Frontiers in Sustainable Water Treatment Technology Book (2017). [29] She is also the editor of Advances in Membrane Technologies (2020). [30]

Honours and awards

Abdelrasoul received multiple academic excellence awards throughout her academic journey from Alexandria University, Kuwait University, and Ryerson University for her academic achievements. Abdelrasoul received the Governor General's Academic Gold Medal in 2015, the most prestigious academic award in Canada, for achieving the highest academic standing in her PhD degree program. [31] She was also granted multiple scholarships due to her outstanding academic record, including Queen Elizabeth QEII GSST, Ryerson Graduate Scholarship, and Ontario Graduate Scholarship twice.

Abdelrasoul received the Best Poster Presentation Award at the Membrane Technology Conference, Orlando, USA, in 2015. [32] She was a recipient of the Norman Esch Engineering Innovation and Entrepreneurship Award twice in 2015 and 2016 [33] for pitching innovative membranes for engineering entrepreneurship startups. [34] She was awarded C. Ravi Ravindran Outstanding Doctoral Thesis Award by Ryerson University in 2015 for her doctoral dissertation. [35] This award recognizes the excellence of the doctoral dissertation from the points of originality, contribution to better understanding of the theory, philosophy, science, practice interrelationship, application of theory and impact on society, industry and environment. [36]

In 2019, she was nominated for the Young Investigator Award by the Journal of Membranes and the Canadian Journal of Chemical Engineering Lectureship Award by the Canadian Society for Chemical Engineering (CSChE). Abdelrasoul was a recipient of the Good Fellow Faculty Travel Award from the University of Saskatchewan in 2019.

Later in 2021, she was nominated for Emerging Star in Chemical Engineering Research and Design Journal. She was also nominated for the Best Supervisor Award twice in 2021 and 2022 and received Best Clinical Paper Award at Life and Health Sciences Research Expo held at the University of Saskatchewan in 2021. [37] [38]

In 2021, Abdelrasoul received Dean's Remote Teaching recognition for her excellence in teaching in the College of Engineering at the University of Saskatchewan. She was named an Outstanding Women Researcher in Chemical Engineering [38] by the Journal of Chemical Engineering Research and Design in 2022. [39] She has also received the Young Investigator Excellence Award by the Canadian Light Source (CLS) Synchrotron, 2022. [40] [41]

Selected media

Related Research Articles

<span class="mw-page-title-main">Kidney dialysis</span> Removal of nitrogenous waste and toxins from the body in place of or to augment the kidney

Kidney Dialysis is the process of removing excess water, solutes, and toxins from the blood in people whose kidneys can no longer perform these functions naturally. This is referred to as renal replacement therapy. The first successful dialysis was performed in 1943.

<span class="mw-page-title-main">Uremia</span> Type of kidney disease, urea in the blood

Uremia is the term for high levels of urea in the blood. Urea is one of the primary components of urine. It can be defined as an excess in the blood of amino acid and protein metabolism end products, such as urea and creatinine, which would be normally excreted in the urine. Uremic syndrome can be defined as the terminal clinical manifestation of kidney failure. It is the signs, symptoms and results from laboratory tests which result from inadequate excretory, regulatory, and endocrine function of the kidneys. Both uremia and uremic syndrome have been used interchangeably to denote a very high plasma urea concentration that is the result of renal failure. The former denotation will be used for the rest of the article.

<span class="mw-page-title-main">Hemodialysis</span> Medical procedure for purifying blood

Hemodialysis, also spelled haemodialysis, or simply dialysis, is a process of purifying the blood of a person whose kidneys are not working normally. This type of dialysis achieves the extracorporeal removal of waste products such as creatinine and urea and free water from the blood when the kidneys are in a state of kidney failure. Hemodialysis is one of three renal replacement therapies. An alternative method for extracorporeal separation of blood components such as plasma or cells is apheresis.

<span class="mw-page-title-main">Chronic kidney disease</span> Medical condition

Chronic kidney disease (CKD) is a type of kidney disease in which a gradual loss of kidney function occurs over a period of months to years. Initially generally no symptoms are seen, but later symptoms may include leg swelling, feeling tired, vomiting, loss of appetite, and confusion. Complications can relate to hormonal dysfunction of the kidneys and include high blood pressure, bone disease, and anemia. Additionally CKD patients have markedly increased cardiovascular complications with increased risks of death and hospitalization.

<span class="mw-page-title-main">Peritoneal dialysis</span> Type of dialysis

Peritoneal dialysis (PD) is a type of dialysis which uses the peritoneum in a person's abdomen as the membrane through which fluid and dissolved substances are exchanged with the blood. It is used to remove excess fluid, correct electrolyte problems, and remove toxins in those with kidney failure. Peritoneal dialysis has better outcomes than hemodialysis during the first couple of years. Other benefits include greater flexibility and better tolerability in those with significant heart disease.

<span class="mw-page-title-main">Home hemodialysis</span>

Home hemodialysis (HHD) is the provision of hemodialysis to purify the blood of a person whose kidneys are not working normally, in their own home. One advantage to doing dialysis at home is that it can be done more frequently and slowly, which reduces the "washed out" feeling and other symptoms caused by rapid ultrafiltration, and it can often be done at night, while the person is sleeping.

Artificial kidney is often a synonym for hemodialysis, but may also refer to the other renal replacement therapies that are in use and/or in development. This article deals mainly with bioengineered kidneys/bioartificial kidneys that are grown from renal cell lines/renal tissue.

<span class="mw-page-title-main">Hemofiltration</span>

Hemofiltration, also haemofiltration, is a renal replacement therapy which is used in the intensive care setting. It is usually used to treat acute kidney injury (AKI), but may be of benefit in multiple organ dysfunction syndrome or sepsis. During hemofiltration, a patient's blood is passed through a set of tubing via a machine to a semipermeable membrane where waste products and water are removed by convection. Replacement fluid is added and the blood is returned to the patient.

Renal replacement therapy (RRT) is therapy that replaces the normal blood-filtering function of the kidneys. It is used when the kidneys are not working well, which is called kidney failure and includes acute kidney injury and chronic kidney disease. Renal replacement therapy includes dialysis, hemofiltration, and hemodiafiltration, which are various ways of filtration of blood with or without machines. Renal replacement therapy also includes kidney transplantation, which is the ultimate form of replacement in that the old kidney is replaced by a donor kidney.

<span class="mw-page-title-main">Willem Johan Kolff</span> Dutch medical researcher (1911–2009)

Willem Johan "Pim" Kolff was a pioneer of hemodialysis, artificial heart, as well as in the entire field of artificial organs. Willem was a member of the Kolff family, an old Dutch patrician family. He made his major discoveries in the field of dialysis for kidney failure during the Second World War. He emigrated in 1950 to the United States, where he obtained US citizenship in 1955, and received a number of awards and widespread recognition for his work.

Vascular access refers to a rapid, direct method of introducing or removing devices or chemicals from the bloodstream. In hemodialysis, vascular access is used to remove the patient's blood so that it can be filtered through the dialyzer. Three primary methods are used to gain access to the blood: an intravenous catheter, an arteriovenous fistula (AV) or a synthetic graft. In the latter two, needles are used to puncture the graft or fistula each time dialysis is performed.

Hemoperfusion or hæmoperfusion is a method of filtering the blood extracorporeally to remove a toxin. As with other extracorporeal methods, such as hemodialysis (HD), hemofiltration (HF), and hemodiafiltration (HDF), the blood travels from the patient into a machine, gets filtered, and then travels back into the patient, typically by venovenous access.

Nils Alwall was a Swedish professor at Lund University, Sweden. He was a pioneer in hemodialysis and the inventor of one of the first practical dialysis machines. Alwall pioneered the technique of ultrafiltration and introduced the principle of hemofiltration. Alwall is referred to as the "father of extracorporeal blood treatment."

<span class="mw-page-title-main">Northwest Kidney Centers</span>

Northwest Kidney Centers is a regional, not-for-profit community-based provider of kidney dialysis, public health education, and research into the causes and treatments of chronic kidney disease. Established in Seattle in 1962, it was the world's first out-of-hospital dialysis provider. It offers dialysis throughout the greater Seattle area in 20 free-standing clinics, eight hospitals and its home dialysis program. It opened its first clinic in Everett in 2020, the organization's first in Snohomish county.

<span class="mw-page-title-main">Robert Provenzano</span> American physician

Robert Provenzano is an American nephrologist. He is also an Associate Clinical Professor of Medicine at Wayne State University School of Medicine.

The Rogosin Institute is an independent, not-for-profit treatment and research center with facilities throughout New York City that treat patients with kidney disease, including dialysis and kidney transplantation; lipid disorders; and hypertension. It is affiliated with NewYork-Presbyterian Hospital, Weill Cornell Medical College and is a leader in research programs for cancer and diabetes.

Nathan W. Levin is an American physician and founder of the Renal Research Institute, LLC., a research institute dedicated to improving the outcomes of patients with kidney disease, particularly those requiring dialysis. Levin is one of the most prominent and renowned figures in clinical nephrology as well as nephrology research. He has authored multiple book chapters and over 350 peer-reviewed publications, including articles in leading journals such as Nature, the New England Journal of Medicine, and The Lancet.

<span class="mw-page-title-main">University of Saskatchewan College of Engineering</span> Faculty at the University of Saskatchewan

The College of Engineering is a faculty at the University of Saskatchewan in Saskatoon, Saskatchewan, Canada.

Ingrid Jane Pickering is a geoscientist. She is a professor and Canada Research Chair in Molecular Environmental Science at the University of Saskatchewan. In 2018, Pickering was the first woman appointed Chair of the Canada Foundation for Innovation Board of Directors.

Ajay Kumar Dalai is an Indian-Canadian chemical engineer. He is a professor and Canada Research Chair of Bioenergy and Environmentally Friendly Chemical Processing at the University of Saskatchewan.

References

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  6. ↑ University of Saskatchewan. "The Division of Biomedical Engineering".
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  18. ↑ Westphalen, Heloisa; Abdelrasoul, Amira; Shoker, Ahmed; Zhu, Ning (2021-03-15). "Assessment of hemodialysis clinical practices using polyaryl ether sulfone-polyvinylpyrrolidone (PAES: PVP) clinical membrane: Modeling of in vitro fibrinogen adsorption, in situ synchrotron-based imaging, and clinical inflammatory biomarkers investigations". Separation and Purification Technology. 259: 118136. doi:10.1016/j.seppur.2020.118136. ISSN   1383-5866. S2CID   229472450.
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  20. ↑ Saadati, Shaghayegh; Westphalen, Heloisa; Eduok, Ubong; Abdelrasoul, Amira; Shoker, Ahmed; Choi, Phillip; Doan, Huu; Ein-Mozaffari, Farhad; Zhu, Ning (2020-12-01). "Biocompatibility enhancement of hemodialysis membranes using a novel zwitterionic copolymer: Experimental, in situ synchrotron imaging, molecular docking, and clinical inflammatory biomarkers investigations". Materials Science and Engineering: C. 117: 111301. doi:10.1016/j.msec.2020.111301. ISSN   0928-4931. PMID   32919662. S2CID   221674049.
  21. ↑ Mollahosseini, Arash; Abdelrasoul, Amira (2022-06-01). "Novel insights in hemodialysis: Most recent theories on membrane hemocompatibility improvement". Biomedical Engineering Advances. 3: 100034. doi: 10.1016/j.bea.2022.100034 . ISSN   2667-0992. S2CID   248735938.
  22. ↑ Eduok, Ubong; Camara, Heloisa; Abdelrasoul, Amira; Shoker, Ahmed (2022-09-12). "Influence of UV‐irradiation intensity and exposure duration on the hemobiocompatibility enhancement of a novel synthesized phosphobetaine zwitterions polyethersulfone clinical hemodialysis membranes". Journal of Biomedical Materials Research Part B: Applied Biomaterials. 110 (3): 573–586. doi:10.1002/jbm.b.34936. ISSN   1552-4973. PMID   34510718. S2CID   237493052.
  23. ↑ Mollahosseini, Arash; Argumeedi, Srija; Abdelrasoul, Amira; Shoker, Ahmed (2020-12-01). "A case study of poly (aryl ether sulfone) hemodialysis membrane interactions with human blood: Molecular dynamics simulation and experimental analyses". Computer Methods and Programs in Biomedicine. 197: 105742. doi:10.1016/j.cmpb.2020.105742. ISSN   0169-2607. PMID   32947069. S2CID   221798755.
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