BIOVIA is a software company headquartered in the United States, with representation in Europe and Asia. It provides software for chemical, materials and bioscience research for the pharmaceutical, biotechnology, consumer packaged goods, aerospace, energy and chemical industries.
Previously named Accelrys, it is a wholly owned subsidiary of Dassault Systèmes after an April 2014 acquisition[1] and has been renamed BIOVIA.[2]
History
Accelrys was formed in 2001 as a wholly owned subsidiary of Pharmacopeia, Inc.[3] from the fusion of five companies: Molecular Simulations Inc., Synopsys Scientific Systems, Oxford Molecular, the Genetics Computer Group (GCG), and Synomics Ltd.[citation needed] MSI, itself a result of the combination of Biodesign, Cambridge Molecular Design, Polygen and, later, Biocad and Biosym Technologies.[4]
In late 2003, Pharmacopeia, Inc. separated its drug discovery and software development businesses. The drug discovery company retained the name Pharmacopeia and remained in Princeton, New Jersey, with ~170 employees. The software company, with ~530 employees and 2002 revenue of $95.1 million, would move to San Diego, California.[5]
On December 22, 2005, Accelrys, Inc. announced to restate its historical financial statements, to reflect changes to the timing of revenue recognition on certain historical term-based contracts, substantially all of which were entered into prior to January 2004.[7]
Accelrys managed a nanotechnology consortium producing software tools for rational nanodesign from 2004 to 2010.[8]
In May 2011, the company acquired Contur Software AB, an electronic lab notebook software firm.[10]
In January 2012, Accelrys acquired VelQuest, a maker of pharmaceutical and medical device-related software, for $35 million in cash.[11]
In May 2012, Accelrys purchased Hit Explorer Operating System (HEOS) - a SaaS system that provides groups with project information in the cloud and access to biological assay results, analytics, chemical registration and pharmacokinetics data - from Scynexis.[12]
In October 2012, Accelrys acquired Aegis Analytical Corp. for $30 million in cash, expanding Accelrys’ reach for customers in the move from the lab to the manufacturing floor.[13] The company's Discoverant software aggregates and analyzes manufacturing, quality and development data to allow manufacturers for quality by design.[14]
In January 2013, Accelrys acquired Swiss biosciences systems integrator Vialis AG for $5 million in cash.[14]
In September 2013, Accelrys acquired Environmental Health & Safety (EH&S) compliance provider ChemSW.[15]
On January 30, 2014 Dassault Systèmes of France announced the acquisition of Accelrys in an all-cash tender offer for at $12.50 per share, representing a fully diluted equity value for Accelrys of approximately $750 million. After the acquisition, Accelrys was renamed BIOVIA.[2]
Products
The Accelrys Enterprise Platform, a scientifically aware, service-oriented architecture (SOA) spanning data management and informatics, enterprise lab management, modeling and simulation, and workflow automation.[16]
Pipeline Pilot, a program that aggregates and provides immediate access to the volumes of disparate research data locked in silos, automates the scientific analysis of that data, and enables researchers to rapidly explore, visualize and report research results.
ISIS/Base, a personal chemical database counterpart.
ISIS/Host, a chemical structure database that uses Oracle
Accelrys Draw, a chemical drawing tool.
Accelrys Direct, a chemical substance database that uses Oracle's data cartridge technology.
The Available Chemicals Directory (ACD) a compilation of supplier catalogues that is searchable by substructure.
The Accelrys Process Management and Compliance Suite, a "combination of software products for scientists working in early and mid-stage analytical, formulation and process/bioprocess development ... through to stability, material and release testing during late-stage quality control and commercial production." The Suite streamlines product development [17]
Materials Studio, a suite of modeling and simulation programs for material science.
Discovery Studio, a suite of modeling and simulation programs for life sciences.
Contur ELN
Externalized Collaboration Suite
Discoverant
iLabber
Experiment Knowledge Base
Lab Execution System (LES)
Commercial versions of otherwise academically licensed programs:
CHARMM (Chemistry at Harvard Macromolecular Mechanics) is commercially available from Accelrys. In October 2013, Martin
Karplus of Harvard University, Michael Levitt of Stanford University and Arieh Warshel of the University of Southern California were awarded the 2013 Nobel Prize in chemistry for their work in modeling and simulation including CHARMM.[18]
Dassault Systèmes SE is a French multinational software corporation which develops software for 3D product design, simulation, manufacturing and other 3D related products.
Symyx Technologies, Inc. was a company that specialized in informatics and automation products. Symyx provided software solutions for scientific research, including Enterprise Laboratory Notebooks and products for combinatorial chemistry. The software part of the business became part of Accelrys, Inc. in 2010 and then in 2014 this company merged with Dassault Systèmes. Symyx also offered laboratory robotics systems for performing automated chemical research, which in 2010 was spun out as Freeslate, Inc.
Chemistry at Harvard Macromolecular Mechanics (CHARMM) is the name of a widely used set of force fields for molecular dynamics, and the name for the molecular dynamics simulation and analysis computer software package associated with them. The CHARMM Development Project involves a worldwide network of developers working with Martin Karplus and his group at Harvard to develop and maintain the CHARMM program. Licenses for this software are available, for a fee, to people and groups working in academia.
A molecule editor is a computer program for creating and modifying representations of chemical structures.
Chemical table file is a family of text-based chemical file formats that describe molecules and chemical reactions. One format, for example, lists each atom in a molecule, the x-y-z coordinates of that atom, and the bonds among the atoms.
Registry of Toxic Effects of Chemical Substances (RTECS) is a database of toxicity information compiled from the open scientific literature without reference to the validity or usefulness of the studies reported. Until 2001 it was maintained by US National Institute for Occupational Safety and Health (NIOSH) as a freely available publication. It is now maintained by the private company BIOVIA or from several value-added resellers and is available only for a fee or by subscription.
SciTegic was a San Diego-based software company that developed and marketed informatics software to the pharmaceutical and biotechnology industries.
MDL Chime was a free plugin used by web browsers to display the three-dimensional structures of molecules. and was based on the RasMol code.
MDL Information Systems, Inc. was a provider of R&D informatics products for the life sciences and chemicals industries. The company was launched as a computer-aided drug design firm in January 1978 in Hayward, California. The company was acquired by Symyx Technologies, Inc. in 2007. Subsequently Accelrys merged with Symyx. The Accelrys name was retained for the combined company. In 2014 Accelrys was acquired by Dassault Systemes. The Accelrys business unit was renamed BIOVIA.
ISIS/Draw was a chemical structure drawing program developed by MDL Information Systems. It introduced a number of file formats for the storage of chemical information that have become industry standards.
Bernard Charlès is a French business executive. He is the chief executive officer and the Chairman of the board of directors of Dassault Systèmes, "the 3DEXPERIENCE Company", world leader in 3D design software, 3D digital mock-up and Product Lifecycle Management (PLM) solutions. Charlès is the 13th best-performing CEO in the world according to the Harvard Business Review 2017 ranking. In 2018 Dassault Systèmes was named the most sustainable corporation in the world in the Global 100 Most Sustainable Corporations in the World index by Corporate Knights. In 2018, he was named one of the "Best CEOs In The World" by the CEOWORLD magazine.
TIBCO Software Inc. is an American business intelligence software company founded in 1997 in Palo Alto, California.
Chemical Computing Group is a software company specializing in research software for computational chemistry, bioinformatics, cheminformatics, docking, pharmacophore searching and molecular simulation. The company's main customer base consists of pharmaceutical and biotechnology companies, as well as academic research groups. It is a private company that was founded in 1994; it is based in Montreal, Quebec, Canada. Its main product, Molecular Operating Environment (MOE), is written in a self-contained programming system, the Scientific Vector Language (SVL).
Materials Studio is software for simulating and modeling materials. It is developed and distributed by BIOVIA, a firm specializing in research software for computational chemistry, bioinformatics, cheminformatics, molecular dynamics simulation, and quantum mechanics.
Abaqus FEA is a software suite for finite element analysis and computer-aided engineering, originally released in 1978. The name and logo of this software are based on the abacus calculation tool. The Abaqus product suite consists of five core software products:
Abaqus/CAE, or "Complete Abaqus Environment". It is a software application used for both the modeling and analysis of mechanical components and assemblies (pre-processing) and visualizing the finite element analysis result. A subset of Abaqus/CAE including only the post-processing module can be launched independently in the Abaqus/Viewer product.
Abaqus/Standard, a general-purpose Finite-Element analyzer that employs implicit integration scheme (traditional).
Abaqus/Explicit, a special-purpose Finite-Element analyzer that employs explicit integration scheme to solve highly nonlinear systems with many complex contacts under transient loads.
Abaqus/CFD, a Computational Fluid Dynamics software application which provides advanced computational fluid dynamics capabilities with extensive support for preprocessing and postprocessing provided in Abaqus/CAE - discontinued in Abaqus 2017 and further releases.
Abaqus/Electromagnetic, a Computational electromagnetics software application which solves advanced computational electromagnetic problems.
Molecular Dynamics of Mixtures (MDynaMix) is a computer software package for general purpose molecular dynamics to simulate mixtures of molecules, interacting by AMBER- and CHARMM-like force fields in periodic boundary conditions. Algorithms are included for NVE, NVT, NPT, anisotropic NPT ensembles, and Ewald summation to treat electrostatic interactions. The code was written in a mix of Fortran 77 and 90. The package runs on Unix and Unix-like (Linux) workstations, clusters of workstations, and on Windows in sequential mode.
Reaction Design is a San Diego-based developer of combustion simulation software used by engineers to design cleaner burning and fuel-efficient combustors and engines, found in everything from automobiles to turbines for power generation and aircraft propulsion to large diesel engines that use pistons the size of rooms to propel ships locomotives. The technology is also used to model spray vaporization in electronic materials processing applications and predict mixing reactions in chemical plants. Ansys, a leader in engineering simulation software, acquired Reaction Design in January 2014.
Discovery Studio is a suite of software for simulating small molecule and macromolecule systems. It is developed and distributed by Dassault Systemes BIOVIA.
Pipeline Pilot is a desktop software program sold by Dassault Systèmes for processing and analyzing data. Originally used in the natural sciences, the product's basic ETL and analytics capabilities have broadened over time. The product is now used for data science, ETL, reporting, prediction, and analytics in a number of sectors. The main feature of the program is the ability to design data workflows using a graphical user interface. It is an example of visual and dataflow programming and has use in a variety of settings, such as cheminformatics and QSAR, Next Generation Sequencing, image analysis, and text analytics. It is not an 'object oriented' programming language.
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