COG7

COG7
Identifiers
Aliases	COG7 , CDG2E, component of oligomeric golgi complex 7
External IDs	OMIM: 606978 MGI: 2685013 HomoloGene: 33431 GeneCards: COG7
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p12.2 Start 23,388,493 bp [1] End 23,453,189 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F2 Start 121,478,586 bp [2] End 121,580,934 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube anterior pituitary canal of the cervix right lobe of thyroid gland left lobe of thyroid gland bronchial epithelial cell trachea minor salivary gland body of stomach skin of abdomen Top expressed in otolith organ utricle supraoptic nucleus retinal pigment epithelium arcuate nucleus paraventricular nucleus of hypothalamus median eminence seminal vesicula sciatic nerve medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nucleolus membrane Golgi apparatus Golgi transport complex trans-Golgi network membrane Golgi membrane Biological process protein localization to organelle protein glycosylation endoplasmic reticulum to Golgi vesicle-mediated transport protein transport protein stabilization intracellular protein transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Golgi organization protein localization to Golgi apparatus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91949 233824 Ensembl ENSG00000168434 ENSMUSG00000034951 UniProt P83436 Q3UM29 RefSeq (mRNA) NM_153603 NM_001033318 RefSeq (protein) NP_705831 NP_001028490 Location (UCSC) Chr 16: 23.39 – 23.45 Mb Chr 7: 121.48 – 121.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

For the Adventist denomination, see Church of God (Seventh-Day).

Conserved oligomeric Golgi complex subunit 7 is a protein that in humans is encoded by the COG7 gene. ^{[5] [6]}

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG7 (Ungar et al., 2002).[supplied by OMIM] ^[6]

Interactions

COG7 has been shown to interact with COG4 ^[7] and COG5. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000168434 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034951 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC   2173297 . PMID   11980916.
6. "Entrez Gene: COG7 component of oligomeric golgi complex 7".
7. Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi: 10.1074/jbc.M400662200 . ISSN   0021-9258. PMID   15047703.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi: 10.1074/jbc.M202326200 . PMID   11929878.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi: 10.1074/jbc.M400662200 . PMID   15047703.
• Wu X, Steet RA, Bohorov O, et al. (2004). "Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder". Nat. Med. 10 (5): 518–23. doi:10.1038/nm1041. PMID   15107842. S2CID   29322859.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Oka T, Vasile E, Penman M, et al. (2005). "Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells". J. Biol. Chem. 280 (38): 32736–45. doi: 10.1074/jbc.M505558200 . PMID   16051600.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Steet R, Kornfeld S (2006). "COG-7-deficient Human Fibroblasts Exhibit Altered Recycling of Golgi Proteins". Mol. Biol. Cell. 17 (5): 2312–21. doi:10.1091/mbc.E05-08-0822. PMC   1446086 . PMID   16510524.
• Morava E, Zeevaert R, Korsch E, et al. (2007). "A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia". Eur. J. Hum. Genet. 15 (6): 638–45. doi: 10.1038/sj.ejhg.5201813 . PMID   17356545.

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
• Human COG7 genome location and COG7 gene details page in the UCSC Genome Browser .