Christopher Bouton

Last updated
Christopher Bouton
Born
Christopher M.L. Bouton

Chicago, Illinois
Occupation Technologist, entrepreneur
Known forBuilding Big Data software company Entagen, which was acquired by Thomson Reuters in October, 2013.

Christopher Bouton is the founder and CEO of Entagen, [1] a software company in the Boston, Massachusetts area, which develops Big Data integration and analytics solutions. Entagen's technologies were named "Innovative Technology of the Year in Big Data" in 2012 by the Massachusetts Technology Leadership Council [2] and Entagen was named a Gartner "Cool Vendor" in the Life Sciences in 2013. [3]

Contents

Entagen was acquired by Thomson Reuters in October, 2013 for an undisclosed amount. [4] [5]

Early life and education

Bouton's mother, Barbara Bouton, worked as an investment banker at Goldman Sachs and his father, Marshall Bouton, is a political scientist who most recently ran the Chicago Council on Global Affairs. [6] [7] Bouton was born in 1973 in Chicago, Illinois. His family moved from Chicago to Brooklyn, New York, New Delhi, India, Washington, DC and then back to Brooklyn.

Bouton attended Saint Ann's School (Brooklyn) for high school. While at Saint Ann's he was awarded sixth place in the Westinghouse Science Talent Search in 1992 [8] [9] for research that he performed at the Jackson Laboratory. He then attended Amherst College for his undergraduate education and Johns Hopkins University for his Ph.D.

While at Johns Hopkins, Bouton worked in the laboratory of Jonathan Pevsner who appeared as a Leonardo da Vinci expert and researcher on the show Doing DaVinci. While in Pevsner's lab, Bouton developed and released the "Database Referencing of Array Genes ONline" (DRAGON) database and DRAGON View analytics systems in 2002, [10] which remains in wide use currently. [11] [12] [13] [ improper synthesis? ] During his doctoral research, Bouton also demonstrated that Synaptotagmin I, an important member of the molecular machinery which governs neurotransmitter release at the synaptic terminal, is a molecular target of lead which may in part contribute to the effects of lead poisoning. [14] Bouton also published on the effects of lead on gene expression [15] [16] and the involvement of presenilins in Alzheimer's Disease. [17]

Career

Following graduation from Johns Hopkins University, Neuroscience Graduate Program, [18] Bouton worked at LION Bioscience Research, Inc. (a subsidiary of LION bioscience AG)) and Aveo Pharmaceuticals (formerly GenPath Pharmaceuticals).

Bouton was recruited in 2004 to the position of Head of Integrative Data Mining at the Pfizer Research Technology Center in Boston, Massachusetts. While at Pfizer, Bouton is credited with having developed the Pfizerpedia, [19] [20] an organizational knowledge base.

In 2008, Bouton founded Entagen. Entagen developed a range of technologies that combined Linked Data [21] and Big Data approaches including Extera and TripleMap. [22] Entagen also participated in the hack/reduce community in the Cambridge, MA area from 2011 - 2014. [23] Entagen's technologies were named "Innovative Technology of the Year in Big Data" in 2012 by the Massachusetts Technology Leadership Council [24] and Entagen was named a Gartner "Cool Vendor" in the Life Sciences in 2013. [25]

Bouton has published a number of papers about Big Data and data integration approaches. [26]

Personal life

Bouton was born in Chicago and has lived in New York, New Delhi, and Washington, DC. He currently lives in Newburyport, Massachusetts. [27]

Related Research Articles

Bioinformatics Computational analysis of large, complex sets of biological data

Bioinformatics is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combines biology, chemistry, physics, computer science, information engineering, mathematics and statistics to analyze and interpret the biological data. Bioinformatics has been used for in silico analyses of biological queries using computational and statistical techniques.

Genomics Discipline in genetics

Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of individual genes and their roles in inheritance, genomics aims at the collective characterization and quantification of all of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advances in genomics have triggered a revolution in discovery-based research and systems biology to facilitate understanding of even the most complex biological systems such as the brain.

Computational biology Branch of biology

Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and big data, the field also has foundations in applied mathematics, chemistry, and genetics. It differs from biological computing, a subfield of computer engineering which uses bioengineering to build computers.

DNA microarray Collection of microscopic DNA spots attached to a solid surface

A DNA microarray is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome. Each DNA spot contains picomoles of a specific DNA sequence, known as probes. These can be a short section of a gene or other DNA element that are used to hybridize a cDNA or cRNA sample under high-stringency conditions. Probe-target hybridization is usually detected and quantified by detection of fluorophore-, silver-, or chemiluminescence-labeled targets to determine relative abundance of nucleic acid sequences in the target. The original nucleic acid arrays were macro arrays approximately 9 cm × 12 cm and the first computerized image based analysis was published in 1981. It was invented by Patrick O. Brown. An example of its application is in SNPs arrays for polymorphisms in cardiovascular diseases, cancer, pathogens and GWAS analysis. It is also used for the identification of structural variations and the measurement of gene expression.

BioPerl Collection of Perl modules for bioinformatics

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Thomson Reuters Canada-based media company

Thomson Reuters Corporation is a Canadian multinational media conglomerate. The company was founded in Toronto, Ontario, Canada, where it is headquartered at the Bay Adelaide Centre.

Human Microbiome Project

The Human Microbiome Project (HMP) was a United States National Institutes of Health (NIH) research initiative to improve understanding of the microbiota involved in human health and disease. Launched in 2007, the first phase (HMP1) focused on identifying and characterizing human microbiota. The second phase, known as the Integrative Human Microbiome Project (iHMP) launched in 2014 with the aim of generating resources to characterize the microbiome and elucidating the roles of microbes in health and disease states. The program received $170 million in funding by the NIH Common Fund from 2007 to 2016.

Syntaxin Group of proteins

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GeneCards is a database of human genes that provides genomic, proteomic, transcriptomic, genetic and functional information on all known and predicted human genes. It is being developed and maintained by the Crown Human Genome Center at the Weizmann Institute of Science.

DNA annotation or genome annotation is the process of identifying the locations of genes and all of the coding regions in a genome and determining what those genes do. An annotation is a note added by way of explanation or commentary. Once a genome is sequenced, it needs to be annotated to make sense of it. Genes in a eukaryotic genome can be annotated using various annotation tools such as FINDER. A modern annotation pipeline can support a user-friendly web interface and software containerization such as MOSGA.

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Ziv Bar-Joseph is an Israeli computational biologist and Professor in the Computational Biology Department and the Machine Learning Department at the Carnegie Mellon School of Computer Science.

Entagen American software company

Entagen is an American software company founded in 2008 by Christopher Bouton. It develops software for big data integration and analytics. Entagen was purchased by Thomson Reuters in 2013.

Transcriptomics technologies are the techniques used to study an organism's transcriptome, the sum of all of its RNA transcripts. The information content of an organism is recorded in the DNA of its genome and expressed through transcription. Here, mRNA serves as a transient intermediary molecule in the information network, whilst non-coding RNAs perform additional diverse functions. A transcriptome captures a snapshot in time of the total transcripts present in a cell. Transcriptomics technologies provide a broad account of which cellular processes are active and which are dormant. A major challenge in molecular biology is to understand how a single genome gives rise to a variety of cells. Another is how gene expression is regulated.

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Clarivate American analytics company

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References

  1. ↑ "Entagen". Archived from the original on 2013-11-29. Retrieved 2013-12-10.
  2. ↑ "2012 Award Winners | Mass TLC Awards". Archived from the original on 2014-05-14. Retrieved 2014-04-16.
  3. ↑ "Gartner Cool Vendors 2014 - Gartner Inc". Archived from the original on May 15, 2011. Retrieved 18 September 2014.
  4. ↑ "BioInform - Informatics - GenomeWeb". November 2013. Retrieved 18 September 2014.
  5. ↑ "Thomson Reuters Cortellis Data Fusion - Thomson Reuters". Archived from the original on 19 October 2014. Retrieved 18 September 2014.
  6. ↑ "Sign In". Archived from the original on 11 July 2014. Retrieved 18 September 2014.
  7. ↑ "The Next Move for Chicago's Diplomat, Marshall Bouton - Chicago magazine - Felsenthal Files March 2013". Chicago magazine. Retrieved 18 September 2014.
  8. ↑ Daniels, Lee A. (10 March 1992). "Long Island Student Wins Westinghouse Contest - New York Times". The New York Times. Retrieved 18 September 2014.
  9. ↑ "STS 1992 Finalist Chris Bouton with Warren H. Hollinshead and Anthony Massaro of Westinghouse - Flickr - Photo Sharing!". Flickr. 20 September 2010. Retrieved 18 September 2014.
  10. ↑ "DRAGON Database" . Retrieved 18 September 2014.
  11. ↑ Bouton CM, Pevsner J (November 2000). "DRAGON: Database Referencing of Array Genes Online". Bioinformatics. 16 (11): 1038–9. doi: 10.1093/bioinformatics/16.11.1038 . PMID   11159315.
  12. ↑ Bouton CM, Pevsner J (February 2002). "DRAGON View: information visualization for annotated microarray data". Bioinformatics. 18 (2): 323–4. doi: 10.1093/bioinformatics/18.2.323 . PMID   11847082.
  13. ↑ Bouton CM, Pevsner J (August 2003). DRAGON and DRAGON view: information annotation and visualization tools for large-scale expression data. Current Protocols in Bioinformatics. Vol. Chapter 7. pp. Unit 7.4. doi:10.1002/0471250953.bi0704s02. ISBN   978-0471250951. PMID   18428707. S2CID   27166855.
  14. ↑ Bouton CM, Frelin LP, Forde CE, Arnold Godwin H, Pevsner J (March 2001). "Synaptotagmin I is a molecular target for lead". Journal of Neurochemistry. 76 (6): 1724–35. doi:10.1046/j.1471-4159.2001.00168.x. PMID   11259490. S2CID   19793239.
  15. ↑ Bouton CM, Pevsner J (December 2000). "Effects of lead on gene expression". Neurotoxicology. 21 (6): 1045–55. PMID   11233751.
  16. ↑ Bouton CM, Hossain MA, Frelin LP, Laterra J, Pevsner J (October 2001). "Microarray analysis of differential gene expression in lead-exposed astrocytes". Toxicology and Applied Pharmacology. 176 (1): 34–53. doi:10.1006/taap.2001.9274. PMID   11578147. S2CID   27688036.
  17. ↑ Thinakaran G, Regard JB, Bouton CM, et al. (April 1998). "Stable association of presenilin derivatives and absence of presenilin interactions with APP". Neurobiology of Disease. 4 (6): 438–53. doi:10.1006/nbdi.1998.0171. PMID   9666482. S2CID   6595619.
  18. ↑ "Neuroscience" . Retrieved 18 September 2014.
  19. ↑ "Chemical & Engineering News: Business - Seeing The Forest At Pfizer" . Retrieved 18 September 2014.
  20. ↑ "Enterprise Collaboration 2.0: Time to Jump In and Swim?". Archived from the original on 11 October 2013. Retrieved 18 September 2014.
  21. ↑ "Christopher Bouton - Semanticweb.com". Archived from the original on 16 April 2014. Retrieved 18 September 2014.
  22. ↑ "Cortellis Data Fusion - Thomson Reuters". Archived from the original on 4 January 2014. Retrieved 18 September 2014.
  23. ↑ "Hack/reduce names data analytics startup Entagen its newest member - Boston Business Journal". Boston Business Journal. 11 December 2012. Retrieved 18 September 2014.
  24. ↑ "2012 Award Winners | Mass TLC Awards". Archived from the original on 2014-05-14. Retrieved 2014-04-16.
  25. ↑ "Gartner Cool Vendors 2014 - Gartner Inc". Archived from the original on May 15, 2011. Retrieved 18 September 2014.
  26. ↑ "Pharma Bio World". www.pharmabioworld.com. Archived from the original on 2014-04-16.
  27. ↑ "Our Team" . Retrieved 18 September 2014.
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