Dual specificity phosphatase 8

DUSP8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JMK
Identifiers
Aliases	DUSP8 , C11orf81, HB5, HVH-5, HVH8, dual specificity phosphatase 8
External IDs	OMIM: 602038 MGI: 106626 HomoloGene: 31239 GeneCards: DUSP8
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.5 Start 1,554,051 bp [1] End 1,572,271 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 F5|7 87.59 cM Start 141,633,227 bp [2] End 141,649,580 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa superior frontal gyrus prefrontal cortex nucleus accumbens putamen temporal lobe amygdala hippocampus proper dorsolateral prefrontal cortex caudate nucleus Top expressed in subiculum Region I of hippocampus proper superior frontal gyrus olfactory tubercle dorsal tegmental nucleus nucleus accumbens cerebellar cortex medial geniculate nucleus cerebellar vermis olfactory bulb More reference expression data BioGPS n/a
Gene ontology Molecular function MAP kinase tyrosine/serine/threonine phosphatase activity phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity phosphatase activity protein tyrosine phosphatase activity Cellular component nucleus cytoplasm cytosol Biological process protein dephosphorylation dephosphorylation peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1850 18218 Ensembl ENSG00000184545 ENSG00000273793 ENSG00000278165 ENSMUSG00000037887 UniProt Q13202 O09112 RefSeq (mRNA) NM_004420 NM_008748 RefSeq (protein) NP_004411 NP_032774 Location (UCSC) Chr 11: 1.55 – 1.57 Mb Chr 7: 141.63 – 141.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity phosphatase 8 is a protein that in humans is encoded by the DUSP8 gene. ^[5]

Function

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

References

1. ENSG00000273793, ENSG00000278165 GRCh38: Ensembl release 89: ENSG00000184545, ENSG00000273793, ENSG00000278165 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037887 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Dual specificity phosphatase 8" . Retrieved 2017-09-08.

Further reading

• Hink RL, Hokanson JE, Shah I, Long JC, Goldman D, Sikela JM (2003). "Investigation of DUSP8 and CALCA in alcohol dependence". Addict Biol. 8 (3): 305–312. doi:10.1080/13556210310001602211. PMID   13129832. S2CID   30875223.
• Berger IR, Buschbeck M, Bange J, Ullrich A (2005). "Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2". Cancer Genet. Cytogenet. 159 (2): 155–159. doi:10.1016/j.cancergencyto.2004.10.010. PMID   15899389.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.