ERLIN2

ERLIN2
Identifiers
Aliases	ERLIN2 , C8orf2, Erlin-2, NET32, SPFH2, SPG18, ER lipid raft associated 2
External IDs	OMIM: 611605 MGI: 2387215 HomoloGene: 5193 GeneCards: ERLIN2
Gene location (Human)
Chr.	Chromosome 8 (human)
End	37,758,422 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	27,530,356 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; Achilles tendon; ; islet of Langerhans; ; parotid gland; ; germinal epithelium; ; bronchial epithelial cell; ; kidney tubule; ; caput epididymis; ; stromal cell of endometrium; ; corpus epididymis;
	Top expressed in
	spermatocyte; ; otolith organ; ; utricle; ; superior cervical ganglion; ; proximal tubule; ; yolk sac; ; kidney; ; epithelium of stomach; ; median eminence; ; jejunum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cholesterol binding ; protein binding ; protein tyrosine kinase activity ; ubiquitin protein ligase binding ;
Cellular component	integral component of membrane ; membrane raft ; membrane ; endoplasmic reticulum ; plasma membrane ; endoplasmic reticulum membrane ; cytosol ; protein-containing complex ;
Biological process	SREBP signaling pathway ; steroid metabolic process ; cholesterol metabolic process ; negative regulation of cholesterol biosynthetic process ; negative regulation of fatty acid biosynthetic process ; lipid metabolism ; ubiquitin-dependent ERAD pathway ; peptidyl-tyrosine phosphorylation ; transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	11160
	244373
	ENSG00000147475
	ENSMUSG00000031483
	O94905
	Q8BFZ9
	NM_001003790 ; NM_001003791 ; NM_007175 ; NM_001362878 ; NM_001362880
NM_153592 ; NM_001364476 ; NM_001364477 ; NM_001379175 ; NM_001379176 ;
	NM_001379177 ; NM_001379178
	NP_001003790 ; NP_001003791 ; NP_009106 ; NP_001349807 ; NP_001349809
NP_705820 ; NP_001351405 ; NP_001351406 ; NP_001366104 ; NP_001366105 ;
	NP_001366106 ; NP_001366107 ; NP_001391043 ; NP_001391044 ; NP_001391045
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 29, 2023

Erlin-2 is a protein that in humans is encoded by the ERLIN2 gene.^[5]^[6]^[7]^[8]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000147475 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031483 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y (Oct 1999). "Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9". Cytogenetics and Cell Genetics. 85 (3–4): 227–31. doi:10.1159/000015298. PMID 10449903. S2CID 39559998.
↑ Garcia MJ, Pole JC, Chin SF, Teschendorff A, Naderi A, Ozdag H, Vias M, Kranjac T, Subkhankulova T, Paish C, Ellis I, Brenton JD, Edwards PA, Caldas C (Aug 2005). "A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes". Oncogene. 24 (33): 5235–45. doi: 10.1038/sj.onc.1208741 . PMID 15897872.
↑ Browman DT, Resek ME, Zajchowski LD, Robbins SM (Aug 2006). "Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER". Journal of Cell Science. 119 (Pt 15): 3149–60. doi: 10.1242/jcs.03060 . PMID 16835267.
↑ "Entrez Gene: ERLIN2 ER lipid raft associated 2".

ERLIN2

Related Research Articles

References

Further reading