Emergency Preservation and Resuscitation

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Emergency Preservation and Resuscitation (EPR) is an experimental medical procedure where an emergency department patient is cooled into suspended animation for an hour to prevent incipient death from ischemia, such as the blood loss following a shooting or stabbing. EPR uses hypothermia, drugs, and fluids to "buy time" for resuscitative surgery. If successful, EPR may someday be deployed in the field so that paramedics can suspend and preserve patients for transport.

Contents

EPR is similar to deep hypothermic circulatory arrest (DHCA) in that hypothermia is induced. However, the purposes and procedures of EPR differ from DHCA. DHCA induces hypothermia to aid preplanned surgery, whereas EPR is an emergency procedure in cases where an emergency department patient is rapidly dying from blood loss and will not otherwise survive long enough for the patient's wounds to be stitched up. In EPR, blood is replaced by a saline solution, and the patient is cooled into a suspended state where metabolism is slowed and brain activity ceases. This gives the surgeon perhaps an hour to close the wounds before a warming and recirculation procedure is applied. [1] [2]

Human trials began in the 2010s. The trial procedure involves rapidly inducing profound hypothermia (10 °C) with an aortic flush in trauma victims that have suffered cardiac arrest and failed standard resuscitative efforts. [3]

History

Peter Rhee, EPR researcher (2006) PeterRheeCamoPortrait.JPG
Peter Rhee, EPR researcher (2006)

Peter Safar, the "father of CPR", and Samuel Tisherman began researching EPR in Pittsburgh in the 1980s, publishing their first results in 1990. [4] New Scientist credits the first demonstration of "swiftly replacing blood with salt water – cooling and effectively 'killing them' to save them" to trials on pigs by Peter Rhee and colleagues at the University of Arizona in 2000. [2] [5] Tisherman continued animal experiments following Safar's death in 2003. [1] Tisherman's research was aided by funding from the Department of Defense, which hopes to someday use EPR to treat soldiers in the field. [6]

Theory

When a cardiac arrest patient arrives at an emergency department with gunshot or stab wounds, doctors have mere minutes to repair wounds and perform necessary resuscitative protocols. EPR is an experimental technique that attempts to improve the odds of survival by dropping the patient's temperature to approximately 10 °C, giving the doctor more time to find and stop the source of the bleeding before brain death occurs. [7] Without oxygen, cells ordinarily can survive around two minutes at normal body temperatures; at EPR temperatures, metabolic rates slow down so that cells can survive for hours. [2] In one EPR protocol, blood is replaced with a 10 °C saline solution using a catheter. The surgeon has perhaps an hour to repair the wound. A heart-lung bypass machine then restarts the blood flow. Next the patient is partially warmed up to about 34 °C, for 12 hours. [1]

In one experiment performed around 2006, 12 of 14 dogs survived EPR, whereas 0 of 7 dogs survived the CPR control group. [8] EPR can utilize equipment like catheters and pumps found in any trauma center. [1]

In the future, advances in technology might allow a paramedic to use EPR in the field until a patient can be taken to hospital. [1]

Human trials

Regulatory approval is complicated by the fact that victims of trauma and cardiac arrest are incapacitated and therefore unable to personally consent to experimental treatment; therefore stringent "community consent" guidelines must be fulfilled in order to gain approval for the experimental EPR operation. [7] Where community consent is obtained, as of 2014, the procedure can only be performed on patients 18 to 65 years old who have a penetrating wound, go into cardiac arrest within five minutes of arrival, and fail to respond to ordinary resuscitation efforts. [1] According to Tisherman, "The patient will probably have already lost about 50 percent of their blood and their chest will be open." Their chance of survival without EPR is less than 7 percent: "When patients have bled so much that the heart stops, we know that we have very little chance of saving them." [2] [6] Tisherman hopes EPR can double the non-EPR survival rate. [9] Tisherman officially launched the round of human trials in April 2014 at the University of Pittsburgh, but was stymied by a lack of qualifying patients; he resumed human trials in Baltimore, which has a higher homicide rate, around 2016. [4] In 2018, Tisherman estimated that results would be available within the next two years. [10]

Samuel Tisherman, a professor at the University of Maryland School of Medicine, is the leader of a team that has successfully put a human being in suspended animation. Describing the successful operation as "a little surreal," Professor Tisherman in November 2019 told how he removed the patient's blood and replaced with ice-cold saline solution. The patient, technically dead at this point, was removed from the cooling system and taken to an operating theatre for a two-hour surgical procedure before having their blood restored and being warmed to the normal temperature of 37C. Prof Tisherman says he will be producing a full account of the procedure in a scientific paper in 2020. [11]

See also

Related Research Articles

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First aid is the first and immediate assistance given to any person with either a minor or serious illness or injury, with care provided to preserve life, prevent the condition from worsening, or to promote recovery until medical services arrive. First aid is generally performed by someone with basic medical training. Mental health first aid is an extension of the concept of first aid to cover mental health, while psychological first aid is used as early treatment of people who are at risk for developing PTSD. Conflict first aid, focused on preservation and recovery of an individual's social or relationship well-being, is being piloted in Canada.

<span class="mw-page-title-main">Cardiac arrest</span> Sudden failure of heart beat

Cardiac arrest, also known as sudden cardiac arrest, is when the heart suddenly and unexpectedly stops beating. As a result, blood cannot properly circulate around the body and there is diminished blood flow to the brain and other organs. When the brain does not receive enough blood, this can cause a person to lose consciousness. Coma and persistent vegetative state may result from cardiac arrest. Cardiac arrest is also identified by a lack of central pulses and abnormal or absent breathing.

<span class="mw-page-title-main">Cardiopulmonary resuscitation</span> Emergency procedure for cardiac arrest

Cardiopulmonary resuscitation (CPR) is an emergency procedure consisting of chest compressions often combined with artificial ventilation, or mouth to mouth in an effort to manually preserve intact brain function until further measures are taken to restore spontaneous blood circulation and breathing in a person who is in cardiac arrest. It is recommended for those who are unresponsive with no breathing or abnormal breathing, for example, agonal respirations.

Clinical death is the medical term for cessation of blood circulation and breathing, the two criteria necessary to sustain the lives of human beings and of many other organisms. It occurs when the heart stops beating in a regular rhythm, a condition called cardiac arrest. The term is also sometimes used in resuscitation research.

<span class="mw-page-title-main">Hypothermia</span> Human body core temperature below 35.0 °C (95.0 °F)

Hypothermia is defined as a body core temperature below 35.0 °C (95.0 °F) in humans. Symptoms depend on the temperature. In mild hypothermia, there is shivering and mental confusion. In moderate hypothermia, shivering stops and confusion increases. In severe hypothermia, there may be hallucinations and paradoxical undressing, in which a person removes their clothing, as well as an increased risk of the heart stopping.

<span class="mw-page-title-main">Suspended animation</span> Slowing or stopping of life without death

Suspended animation is the temporary slowing or stopping of biological function so that physiological capabilities are preserved. States of suspended animation are common in micro-organisms and some plant tissue, such as seeds. Many animals, including large ones, may undergo hibernation, and most plants have periods of dormancy. This article focuses primarily on the potential of large animals, especially humans, to undergo suspended animation.

<span class="mw-page-title-main">Major trauma</span> Injury that could cause prolonged disability or death

Major trauma is any injury that has the potential to cause prolonged disability or death. There are many causes of major trauma, blunt and penetrating, including falls, motor vehicle collisions, stabbing wounds, and gunshot wounds. Depending on the severity of injury, quickness of management, and transportation to an appropriate medical facility may be necessary to prevent loss of life or limb. The initial assessment is critical, and involves a physical evaluation and also may include the use of imaging tools to determine the types of injuries accurately and to formulate a course of treatment.

<span class="mw-page-title-main">Hypovolemic shock</span> Medical condition

Hypovolemic shock is a form of shock caused by severe hypovolemia. It could be the result of severe dehydration through a variety of mechanisms or blood loss. Hypovolemic shock is a medical emergency; if left untreated, the insufficient blood flow can cause damage to organs, leading to multiple organ failure.

<span class="mw-page-title-main">Traumatic cardiac arrest</span> Medical condition

Traumatic cardiac arrest (TCA) is a condition in which the heart has ceased to beat due to blunt or penetrating trauma, such as a stab wound to the thoracic area. It is a medical emergency which will always result in death without prompt advanced medical care. Even with prompt medical intervention, survival without neurological complications is rare. In recent years, protocols have been proposed to improve survival rate in patients with traumatic cardiac arrest, though the variable causes of this condition as well as many coexisting injuries can make these protocols difficult to standardize. Traumatic cardiac arrest is a complex form of cardiac arrest often derailing from advanced cardiac life support in the sense that the emergency team must first establish the cause of the traumatic arrest and reverse these effects, for example hypovolemia and haemorrhagic shock due to a penetrating injury.

<span class="mw-page-title-main">J wave</span> Abnormal electrocardiogram finding

A J wave — also known as Osborn wave, camel-hump sign, late delta wave, hathook junction, hypothermic wave, K wave, H wave or current of injury — is an abnormal electrocardiogram finding.

Deep hypothermic circulatory arrest (DHCA) is a surgical technique in which the temperature of the body falls significantly and blood circulation is stopped for up to one hour. It is used when blood circulation to the brain must be stopped because of delicate surgery within the brain, or because of surgery on large blood vessels that lead to or from the brain. DHCA is used to provide a better visual field during surgery due to the cessation of blood flow. DHCA is a form of carefully managed clinical death in which heartbeat and all brain activity cease.

Targeted temperature management (TTM) previously known as therapeutic hypothermia or protective hypothermia is an active treatment that tries to achieve and maintain a specific body temperature in a person for a specific duration of time in an effort to improve health outcomes during recovery after a period of stopped blood flow to the brain. This is done in an attempt to reduce the risk of tissue injury following lack of blood flow. Periods of poor blood flow may be due to cardiac arrest or the blockage of an artery by a clot as in the case of a stroke.

The Arctic Sun Temperature Management System is a non-invasive targeted temperature management system. It modulates patient temperature by circulating chilled water in pads directly adhered to the patient's skin. Using varying water temperatures and a computer algorithm, a patient's body temperature can be better controlled. It is produced by Medivance, Inc. of Louisville, Colorado.

The Hs and Ts is a mnemonic used to aid in remembering the possible reversible causes of cardiac arrest. A variety of disease processes can lead to a cardiac arrest; however, they usually boil down to one or more of the "Hs and Ts".

Permissive hypotension or hypotensive resuscitation is the use of restrictive fluid therapy, specifically in the trauma patient, that increases systemic blood pressure without reaching normotension. The goal blood pressure for these patients is a mean arterial pressure of 40-50 mmHg or systolic blood pressure of less than or equal to 80. This goes along with certain clinical criteria. Following traumatic injury, some patients experience hypotension that is usually due to blood loss (hemorrhage) but can be due to other causes as well. In the past, physicians were very aggressive with fluid resuscitation to try to bring the blood pressure to normal values. Recent studies have found that there is some benefit to allowing specific patients to experience some degree of hypotension in certain settings. This concept does not exclude therapy by means of i.v. fluid, inotropes or vasopressors, the only restriction is to avoid completely normalizing blood pressure in a context where blood loss may be enhanced. When a person starts to bleed the body starts a natural coagulation process that eventually stops the bleed. Issues with fluid resuscitation without control of bleeding are thought to be secondary to dislodgement of the thrombus that is helping to control further bleeding. Thrombus dislodgement was found to occur at a systolic pressure greater than 80mm Hg. In addition, fluid resuscitation will dilute coagulation factors that help form and stabilize a clot, hence making it harder for the body to use its natural mechanisms to stop the bleeding. These factors are aggravated by hypothermia.

A transmediastinal gunshot wound (TMGSW) is a penetrating injury to a person's thorax in which a bullet enters the mediastinum, possibly damaging some of the major structures in this area. Hemodynamic instability has been reported in about 50% of cases with a mortality rate ranging from 20% to 49%. Some studies have shown marked improvement in the mortality rate of patients who survived transfer to the operating room rather than being treated surgically in the ER.

<span class="mw-page-title-main">Resuscitative thoracotomy</span> Type of thoracotomy

A resuscitative thoracotomy (sometimes referred to as an emergency department thoracotomy (EDT), trauma thoracotomy or, colloquially, as "cracking the chest") is a thoracotomy performed to aid in the resuscitation of a major trauma patient who has sustained severe thoracic or abdominal trauma. The procedure allows immediate direct access to the thoracic cavity, permitting rescuers to control hemorrhage, relieve cardiac tamponade, repair or control major injuries to the heart, lungs or thoracic vasculature, and perform direct cardiac massage or defibrillation. The procedure is rarely performed and is a procedure of last resort.

Extracorporeal cardiopulmonary resuscitation is a method of cardiopulmonary resuscitation (CPR) that passes the patient's blood through a machine in a process to oxygenate the blood supply. A portable extracorporeal membrane oxygenation (ECMO) device is used as an adjunct to standard CPR. A patient who is deemed to be in cardiac arrest refractory to CPR has percutaneous catheters inserted into the femoral vein and artery. Theoretically, the application of ECPR allows for the return of cerebral perfusion in a more sustainable manner than with external compressions alone. By attaching an ECMO device to a person who has acutely undergone cardiovascular collapse, practitioners can maintain end-organ perfusion whilst assessing the potential reversal of causal pathology, with the goal of improving long-term survival and neurological outcomes.

Lance B. Becker is an American physician and academic, specializing in emergency medicine and treatment for cardiac arrest, currently at Northwell Health. He is the chairman of the department of emergency medicine at North Shore University Hospital, as well as chair and professor of emergency medicine at Hofstra Northwell School of Medicine.

<span class="mw-page-title-main">Hasan B. Alam</span> Pakistani-American surgeon

Hasan Badre Alam is a trauma surgeon, surgeon-scientist, and a medical professor in the United States. He is the Loyal and Edith Davis Professor of Surgery, the Chairman of Department of Surgery at the Feinberg School of Medicine (FSM)/Northwestern University, and the Surgeon-in-Chief at Northwestern Memorial Hospital (NMH) in Chicago.

References

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  4. 1 2 Twilley, Nicola (21 November 2016). "Can Hypothermia Save Gunshot Victims?". The New Yorker. Retrieved 23 January 2018.
  5. Kaplan, Sarah (20 January 2016). "Being frozen 'to death' saved this man's life. It could save others,' too". Washington Post. Retrieved 23 January 2018.
  6. 1 2 "Cheating death through 'suspended animation'". CNN. 23 June 2014. Retrieved 23 January 2018.
  7. 1 2 Sun, Baltimore. "Shock Trauma looking for way to prolong lives of gunshot victims in cardiac arrest".
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  9. "How Scientists Are Bringing People Back From The Dead". Popular Science. 28 July 2016. Retrieved 23 January 2018.
  10. "How cold water could save patients from almost certain death". NBC News. 22 January 2018. Retrieved 23 January 2018.
  11. Thomson, Helen. "Humans placed in suspended animation for the first time". New Scientist. Retrieved 29 April 2020.