Fowl cholera

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Cock of a breeding flock with green diarrhea Colera poyes schite.jpg
Cock of a breeding flock with green diarrhea

Fowl cholera is also called avian cholera, avian pasteurellosis and avian hemorrhagic septicemia. [1]

Contents

It is the most common pasteurellosis of poultry. As the causative agent is Pasteurella multocida , it is considered to be a zoonosis.

Adult birds and old chickens are more susceptible. In parental flocks, cocks are far more susceptible than hens. [2]

Besides chickens, the disease also concerns turkeys, ducks, geese, raptors, and canaries. Turkeys are particularly sensitive, with mortality ranging to 65%. [3]

The recognition of this pathological condition is of ever increasing importance for differential diagnosis with avian influenza.

History

The disease was first recorded in the 18th century. In 1879, Pasteur received a bacterial sample from Jean Joseph Henri Toussaint DVM, Professor, Toulouse Veterinary College who had been working with Fowl Cholera. Louis Pasteur then isolated and grew it in pure culture. Originally a disease of fowl in Europe, it was first recorded in North America in 1943–44. Since then outbreaks have been recorded almost annually in wild birds. Today, this disease is most prevalent in wild waterfowl of North America. [4]

In December 1880, Pasteur announced to the French Academy of Sciences that he was working on a vaccine against fowl cholera. [5] In fact, Pasteur's vaccine had irregular effects and was a failure. [6]

In 2011 an outbreak of avian cholera killed thousands of eider ducks in Arctic regions of Canada. Scientists are studying the outbreak and its potential to spread to Greenland. [7] [8]

In March 2015, another outbreak of avian cholera killed roughly 2,000 snow geese in northern Idaho while flying their spring migration to Canada. [9] [10]

Epidemiology

Outbreaks occur in cold and wet weather (in late summer, fall and winter). The outbreaks are often traced back to the presence of rodents in the breeding houses. These are thought to spread the disease from carcasses of dead birds (possibly from neighboring backyards), improperly disposed of. Once the disease is introduced to a flock, it will stay until culling. Chronic carriers can always lead to re-emerging of the disease in susceptible birds...

In wild birds, this disease is most commonly associated with wetlands. Blanchong et al. [11] determined that wetlands act as short term reservoirs, recording large amounts of the bacterium in the soil and water through the duration of the outbreak. Wetlands, however, are not long term reservoirs.

The disease presents in two very different forms: acute and chronic. Birds with chronic avian cholera, more common in domestic fowl, exhibit prolonged illness with more localized infections. Chronic infection has been demonstrated in snow geese, and these individuals are believed to be long term migrating reservoirs for the disease.

Once the bacteria gets introduced into a population of susceptible birds, an outbreak of acute avian cholera follows. Infected birds will die 6–12 hours after contracting the bacterium, and very few ill birds have been described. [12] Due to association and dense aggregations, waterfowl are most commonly affected by P. multocida, however scavengers and other water birds are often affected in large multi-species outbreaks. [13]

Clinical signs and post-mortem lesions

Necrotic foci on liver Colera poyes necroze foete.jpg
Necrotic foci on liver

In acute cases, a green diarrhea can be an early symptom.

The most typical symptom, in chronic cases, is the swelling of the wattles. It is more frequent in resistant local breeds. Rather than a general infection, localized infections are more characteristic. These often occur in the respiratory tract including the sinuses and pneumatics bones, hock joints, sternal bursa, foot pads, peritoneal cavity and oviducts. [14]

In acute cases, the most typical post-mortem lesion is the petechiae observed in the epicardial fatty tissue. Necrotic foci on liver are usually found and general hyperemia is common. Due to the speed of infection and mortality, birds are in good body condition and do not exhibit the signs of prolonged illness.

Treatment

The most efficient treatment in breeding flocks or laying hens is individual intramuscular injections of a long-acting tetracycline, with the same antibiotic in drinking water, simultaneously. The mortality and clinical signs will stop within one week, but the bacteria might remain present in the flock.

Related Research Articles

<span class="mw-page-title-main">Pasteurellosis</span> Medical condition

Pasteurellosis is an infection with a species of the bacterial genus Pasteurella, which is found in humans and other animals.

<span class="mw-page-title-main">Avian influenza</span> Influenza caused by viruses adapted to birds

Avian influenza, known informally as avian flu, is a bird flu caused by the influenza A virus, which can infect people. It is similar to other types of animal flu in that it is caused by a virus strain that has adapted to a specific host. The type with the greatest risk is highly pathogenic avian influenza (HPAI).

<span class="mw-page-title-main">Virulent Newcastle disease</span> Contagious viral avian disease

Virulent Newcastle disease (VND), formerly exotic Newcastle disease, is a contagious viral avian disease affecting many domestic and wild bird species; it is transmissible to humans. Though it can infect humans, most cases are non-symptomatic; rarely it can cause a mild fever and influenza-like symptoms and/or conjunctivitis in humans. Its effects are most notable in domestic poultry due to their high susceptibility and the potential for severe impacts of an epizootic on the poultry industries. It is endemic to many countries. No treatment for VND is known, but the use of prophylactic vaccines and sanitary measures reduces the likelihood of outbreaks.

<span class="mw-page-title-main">Influenza A virus subtype H5N1</span> Subtype of influenza A virus

Influenza A virus subtype H5N1 (A/H5N1) is a subtype of the influenza A virus which can cause illness in humans and many other species. A bird-adapted strain of H5N1, called HPAI A(H5N1) for highly pathogenic avian influenza virus of type A of subtype H5N1, is the highly pathogenic causative agent of H5N1 flu, commonly known as avian influenza. It is enzootic in many bird populations, especially in Southeast Asia. One strain of HPAI A(H5N1) is spreading globally after first appearing in Asia. It is epizootic and panzootic, killing tens of millions of birds and spurring the culling of hundreds of millions of others to stem its spread. Many references to "bird flu" and H5N1 in the popular media refer to this strain.

<span class="mw-page-title-main">Infectious bursal disease</span> Viral disease of poultry

Infectious bursal disease (IBD), also known as Gumboro disease, infectious bursitis and infectious avian nephrosis, is a highly contagious disease of young chickens and turkeys caused by infectious bursal disease virus (IBDV), characterized by immunosuppression and mortality generally at 3 to 6 weeks of age. The disease was first discovered in Gumboro, Delaware in 1962. It is economically important to the poultry industry worldwide due to increased susceptibility to other diseases and negative interference with effective vaccination. In recent years, very virulent strains of IBDV (vvIBDV), causing severe mortality in chicken, have emerged in Europe, Latin America, South-East Asia, Africa and the Middle East. Infection is via the oro-fecal route, with affected bird excreting high levels of the virus for approximately 2 weeks after infection. The disease is easily spread from infected chickens to healthy chickens through food, water, and physical contact.

Avian infectious bronchitis (IB) is an acute and highly contagious respiratory disease of chickens. The disease is caused by avian infectious bronchitis virus (IBV), a coronavirus, and characterized by respiratory signs including gasping, coughing, sneezing, tracheal rales, and nasal discharge. In young chickens, severe respiratory distress may occur. In layers, respiratory distress, nephritis, decrease in egg production, and loss of internal and external egg quality are reported.

Marek's disease is a highly contagious viral neoplastic disease in chickens. It is named after József Marek, a Hungarian veterinarian who described it in 1907. Marek's disease is caused by an alphaherpesvirus known as "Marek's disease virus" (MDV) or Gallid alphaherpesvirus 2 (GaHV-2). The disease is characterized by the presence of T cell lymphoma as well as infiltration of nerves and organs by lymphocytes. Viruses related to MDV appear to be benign and can be used as vaccine strains to prevent Marek's disease. For example, the related herpesvirus found in turkeys (HVT), causes no apparent disease in the birds, and continues to be used as a vaccine strain for prevention of Marek's disease.

<i>Pasteurella</i> Genus of bacteria

Pasteurella is a genus of Gram-negative, facultatively anaerobic bacteria. Pasteurella species are nonmotile and pleomorphic, and often exhibit bipolar staining. Most species are catalase- and oxidase-positive. The genus is named after the French chemist and microbiologist, Louis Pasteur, who first identified the bacteria now known as Pasteurella multocida as the agent of chicken cholera.

Singapore has taken a series of measures against avian influenza and the potential threat of a pandemic.

<span class="mw-page-title-main">Transmission and infection of H5N1</span> Spread of an influenza virus

Transmission and infection of H5N1 from infected avian sources to humans has been a concern since the first documented case of human infection in 1997, due to the global spread of H5N1 that constitutes a pandemic threat.

<span class="mw-page-title-main">Duck plague</span> Disease caused by Anatid alphaherpesvirus 1

Duck plague is a worldwide disease caused by Anatid alphaherpesvirus 1 (AnHV-1) of the family Herpesviridae that causes acute disease with high mortality rates in flocks of ducks, geese, and swans. It is spread both vertically and horizontally—through contaminated water and direct contact. Migratory waterfowl are a major factor in the spread of this disease as they are often asymptomatic carriers of disease. The incubation period is three to seven days. Birds as young as one week old can be infected. DEV is not zoonotic.

<span class="mw-page-title-main">Fowlpox</span> Viral disease of poultry

Fowlpox is the worldwide disease of poultry caused by viruses of the family Poxviridae and the genus Avipoxvirus. The viruses causing fowlpox are distinct from one another but antigenically similar, possible hosts including chickens, turkeys, quail, canaries, pigeons, and many other species of birds. There are two forms of the disease. The first is spread by biting insects and wound contamination and causes lesions on the comb, wattles, and beak. Birds affected by this form usually recover within a few weeks. It can also be transmitted via inhalation or ingestion of dust, or aerosols, leading to the 'diphtheritic form' of the disease, with lesions on the mucous membranes of the mouth, pharynx, larynx, and sometimes trachea. The second form is spread by inhalation of the virus and causes a diphtheritic membrane to form in the mouth, pharynx, larynx, and sometimes the trachea. The prognosis for this form is poor.

<span class="mw-page-title-main">Global spread of H5N1 in 2004</span>

The global spread of H5N1 in birds is considered a significant pandemic threat.

<i>Pasteurella multocida</i> Species of bacterium

Pasteurella multocida is a Gram-negative, nonmotile, penicillin-sensitive coccobacillus of the family Pasteurellaceae. Strains of the species are currently classified into five serogroups based on capsular composition and 16 somatic serovars (1–16). P. multocida is the cause of a range of diseases in mammals and birds, including fowl cholera in poultry, atrophic rhinitis in pigs, and bovine hemorrhagic septicemia in cattle and buffalo. It can also cause a zoonotic infection in humans, which typically is a result of bites or scratches from domestic pets. Many mammals and birds harbor it as part of their normal respiratory microbiota.

<span class="mw-page-title-main">Water bird</span> Bird that lives on or around water

A water bird, alternatively waterbird or aquatic bird, is a bird that lives on or around water. In some definitions, the term water bird is especially applied to birds in freshwater ecosystems, although others make no distinction from seabirds that inhabit marine environments. Some water birds are more terrestrial while others are more aquatic, and their adaptations will vary depending on their environment. These adaptations include webbed feet, beaks, and legs adapted to feed in the water, and the ability to dive from the surface or the air to catch prey in water.

<span class="mw-page-title-main">Histomoniasis</span> Medical condition

Histomoniasis is a commercially significant disease of poultry, particularly of chickens and turkeys, due to parasitic infection of a protozoan, Histomonas meleagridis. The protozoan is transmitted to the bird by the nematode parasite Heterakis gallinarum. H. meleagridis resides within the eggs of H. gallinarum, so birds ingest the parasites along with contaminated soil or food. Earthworms can also act as a paratenic host.

Haemorrhagic septicaemia is one of the most economically important pasteurelloses. Haemorrhagic septicaemia in cattle and buffaloes was previously known to be associated with one of two serotypes of P. multocida: Asian B:2 and African E:2 according to the Carter-Heddleston system, or 6:B and 6:E using the Namioka-Carter system.

<span class="mw-page-title-main">Egg drop syndrome</span> Viral disease of birds

Egg drop syndrome '76 is a viral disease that affects birds, notably chickens, ducks, geese and swans. It is characterised by a sudden drop in production of eggs as well as its eggshell quality in apparent healthy laying birds.

<span class="mw-page-title-main">2015 United States H5N2 outbreak</span> 2015 outbreak of avian influenza subtype H5N2

In 2015, an outbreak of avian influenza subtype H5N2 was identified in a series of chicken and turkey farming operations in the Midwestern United States. By May 30, more than 43 million birds in 15 states had been destroyed as a result of the outbreak, including nearly 30 million in Iowa alone, the nation's largest egg producer. In the Midwestern U.S., the average price of eggs had increased 120% between April 22 and May 30. The effects however were seen nationwide, with prices in California up 71% in the same timeframe.

<span class="mw-page-title-main">Jessie Isabelle Price</span> Veterinary microbiologist

Jessie Isabelle Price was a veterinary microbiologist. She isolated and reproduced the cause of the most common life-threatening disease in duck farming in the 1950s and developed vaccines for this and other avian diseases. A graduate of Cornell University, where she gained a PhD (1959), she worked first at the Cornell Duck Research Laboratory and later at the USGS National Wildlife Health Center. She served as chair of the Predoctoral Minority Fellowship Ad Hoc Review Committee of the American Society for Microbiology (ASM), and as president of Graduate Women in Science.

References

  1. K.R. Rhoades and R.B. Rimler, Avian pasteurellosis, in "Diseases of poultry", ed. by M.S. Hofstad, Iowa State University Press, Ames, Iowa, USA ISBN   0-8138-0430-2, p. 141.
  2. Hassan Iraqui, Observation on an outbreak of fowl cholera in a parental broiler flock, Azrou, Morocco, October 2007, unpublished data.
  3. Alberts and Graham (1948), quoted in "Diseases of poultry", op. cit.
  4. Botzler. 1991. Epizootiology of Avian Cholera in Wildfowl. Journal of Wildlife Diseases. Chicken Cholera was Observed by Louis Pasteur by luck because it was only when he went on holiday and left his chicken with some cold vaccine to come home to find it dead he realise then the potential opportunity to make a new vaccine 27:367-395
  5. Pasteur, Œuvres complètes, vol. 6, p.|329, online.
  6. "This way, which the genius of Pasteur had opened and which became so fruitful, soon proved to be closed with regard to the anti-pasteurellic vaccination of the hen. Difficulties arose in the regularity of attenuation and maintenance of virulence to a definite and fixed degree." (G. Lesbouyries, La pathologie des oiseaux, Paris, 1941, p. 340; quoted by Hervé Bazin, L'Histoire des vaccinations, John Libbey Eurotext, 2008, p. 155.)
  7. "Avian cholera may spread in Arctic: scientists".
  8. "canada.com - Page Not Found" via Canada.com.{{cite web}}: Cite uses generic title (help)
  9. Karimi, Faith. "2,000 snow geese drop dead from the sky in Idaho". CNN.
  10. "Press Releases". Idaho Fish and Game.
  11. Blanchong et al. 2006. Persistence of Pasteurella multocida in Wetlands Following Avian Cholera Outbreaks. Journal of Wildlife Diseases. 42: 33-39
  12. Samuel et al. 2005. Avian Cholera in Waterfowl: The role of Lesser Snow Geese and Ross's Geese Carriers in the Playa Lakes Region. Journal of Wildlife Diseases
  13. Blanchong et al. 2006. Multi-species patterns of avian cholera mortality in Nebraska's rainwater basin. Journal of Wildlife Diseases. 42: 81-91
  14. K.R. Rhoades and R.B. Rimler, Avian pasteurellosis, in "Diseases of poultry", ed. by M.S. Hofstad, Iowa State University Press, Ames, Iowa, USA ISBN   0-8138-0430-2, p. 141