Gem-associated protein 2

Last updated
GEMIN2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GEMIN2 , SIP1, SIP1-delta, Survival of motor neuron protein-interacting protein 1, gem nuclear organelle associated protein 2
External IDs OMIM: 602595; MGI: 1913853; HomoloGene: 37827; GeneCards: GEMIN2; OMA:GEMIN2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001009182
NM_001009183
NM_003616

NM_025656

RefSeq (protein)

NP_001009182
NP_001009183
NP_003607

NP_079932

Location (UCSC) Chr 14: 39.11 – 39.14 Mb Chr 12: 59.06 – 59.08 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that in humans is encoded by the GEMIN2 gene. [5] [6] [7]

Contents

Interactions

Gem-associated protein 2 has been shown to interact with DDX20 [8] [9] and SMN1. [6] [10]

See also

Related Research Articles

Gideon Dreyfuss is an American biochemist, the Isaac Norris Professor of Biochemistry and Biophysics at the University of Pennsylvania School of Medicine, and an investigator of the Howard Hughes Medical Institute. He was elected to the National Academy of Sciences in 2012.

<span class="mw-page-title-main">Survival of motor neuron</span> Protein in animal cells

Survival of motor neuron or survival motor neuron (SMN) is a protein that in humans is encoded by the SMN1 and SMN2 genes.

<span class="mw-page-title-main">Fibrillarin</span> Protein-coding gene in the species Homo sapiens

rRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene.

<i>SMN1</i> Protein-coding gene in the species Homo sapiens

Survival of motor neuron 1 (SMN1), also known as component of gems 1 or GEMIN1, is a gene that encodes the SMN protein in humans.

<span class="mw-page-title-main">Small nuclear ribonucleoprotein D1</span> Protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.

<span class="mw-page-title-main">SNRPB</span> Protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.

<span class="mw-page-title-main">Small nuclear ribonucleoprotein D2</span> Protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

<span class="mw-page-title-main">Small nuclear ribonucleoprotein polypeptide E</span> Protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein E is a protein that in humans is encoded by the SNRPE gene.

<span class="mw-page-title-main">SNRPD3</span> Protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.

<span class="mw-page-title-main">DDX20</span> Protein-coding gene in the species Homo sapiens

Probable ATP-dependent RNA helicase DDX20, also known as DEAD-box helicase 20 and gem-associated protein 3 (GEMIN3), is an enzyme that in humans is encoded by the DDX20 gene.

<span class="mw-page-title-main">Small nuclear ribonucleoprotein polypeptide F</span> Protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.

<span class="mw-page-title-main">SNRPB2</span> Protein-coding gene in the species Homo sapiens

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.

<span class="mw-page-title-main">SNRPG</span> Protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein G is a protein that in humans is encoded by the SNRPG gene.

<span class="mw-page-title-main">Nucleolar protein, member A1</span> Protein-coding gene in the species Homo sapiens

H/ACA ribonucleoprotein complex subunit 1 is a protein that in humans is encoded by the GAR1 gene.

<span class="mw-page-title-main">Gem-associated protein 7</span> Protein-coding gene in the species Homo sapiens

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene. The gem-associated proteins are those found in the gems of Cajal bodies.

<span class="mw-page-title-main">Gem-associated protein 6</span> Protein-coding gene in the species Homo sapiens

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene. The gem-associated proteins are those found in the gems of Cajal bodies.

<span class="mw-page-title-main">Gem-associated protein 4</span> Protein-coding gene in the species Homo sapiens

Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene.

<span class="mw-page-title-main">HNRNPR</span> Protein-coding gene in the species Homo sapiens

Heterogeneous nuclear ribonucleoprotein R is a protein that in humans is encoded by the HNRNPR gene.

<span class="mw-page-title-main">Gem-associated protein 5</span> Protein-coding gene in the species Homo sapiens

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.

<i>SMN2</i> Protein-coding gene in the species Homo sapiens

Survival of motor neuron 2 (SMN2) is a gene that encodes the SMN protein in humans.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000092208 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060121 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fischer U, Liu Q, Dreyfuss G (September 1997). "The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis". Cell. 90 (6): 1023–1029. doi: 10.1016/S0092-8674(00)80368-2 . PMID   9323130.
  6. 1 2 Liu Q, Fischer U, Wang F, Dreyfuss G (September 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–1021. doi: 10.1016/S0092-8674(00)80367-0 . PMID   9323129.
  7. "Entrez Gene: SIP1 survival of motor neuron protein interacting protein 1".
  8. Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, et al. (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes & Development. 16 (6): 720–728. doi:10.1101/gad.974702. PMC   155365 . PMID   11914277.
  9. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–1194. doi:10.1083/jcb.147.6.1181. PMC   2168095 . PMID   10601333.
  10. Meister G, Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Human Molecular Genetics. 9 (13): 1977–1986. doi: 10.1093/hmg/9.13.1977 . PMID   10942426.

Further reading