HIST1H1B

Last updated
H1-5
Protein HIST1H1B PDB 1ghc.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases H1-5 , H1, H1.5, H1B, H1F5, H1s-3, histone cluster 1, H1b, histone cluster 1 H1 family member b, HIST1H1B, H1.5 linker histone, cluster member
External IDs OMIM: 142711 HomoloGene: 136789 GeneCards: H1-5
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005322

n/a

RefSeq (protein)

NP_005313

n/a

Location (UCSC) Chr 6: 27.87 – 27.87 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Histone H1.5 is a protein that in humans is encoded by the HIST1H1B gene. [3] [4] [5] [6]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [6]


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<span class="mw-page-title-main">HIST1H2AB</span> Protein-coding gene in the species Homo sapiens

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000184357 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Albig W, Meergans T, Doenecke D (Mar 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene. 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID   9031620.
  4. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID   9119399.
  5. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID   12408966.
  6. 1 2 "Entrez Gene: HIST1H1B histone cluster 1, H1b".

Further reading