Liprin-alpha-1

PPFIA1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1N7F
Identifiers
Aliases	PPFIA1 , LIP.1, LIP1, LIPRIN, PTPRF interacting protein alpha 1
External IDs	OMIM: 611054 MGI: 1924750 HomoloGene: 20802 GeneCards: PPFIA1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.3 Start 70,270,690 bp [1] End 70,385,312 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F5 Start 144,030,495 bp [2] End 144,107,466 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve oocyte secondary oocyte sperm Achilles tendon endothelial cell tibia visceral pleura parietal pleura anterior pituitary Top expressed in secondary oocyte superior cervical ganglion lip esophagus hair follicle morula spermatocyte cerebellar cortex hand thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signal transducer activity Cellular component presynaptic active zone focal adhesion cytoplasm cytosol axon dendrite protein-containing complex Biological process cell-matrix adhesion negative regulation of stress fiber assembly signal transduction negative regulation of protein localization to plasma membrane neurotransmitter secretion glutamate secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8500 233977 Ensembl ENSG00000131626 ENSG00000288198 ENSMUSG00000037519 UniProt Q13136 n/a RefSeq (mRNA) NM_003626 NM_177423 NM_001378006 NM_001033319 NM_001195086 RefSeq (protein) NP_003617 NP_803172 NP_001364935 n/a Location (UCSC) Chr 11: 70.27 – 70.39 Mb Chr 7: 144.03 – 144.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Liprin-alpha-1 is a protein that in humans is encoded by the PPFIA1 gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene is a member of the LAR protein tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. ^[7]

Interactions

Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 has been shown to interact with:

• ERC2, ^[8]
• GIT1, ^{[8] [9]}
• GRIP2, ^{[8] [9]}
• PPFIBP1, ^[6]
• PPP2R5D, ^[10]
• PTPRD, ^[11]
• PTPRF, ^{[5] [6] [11]} and
• PTPRS. ^{[6] [11]}

References

1. ENSG00000288198 GRCh38: Ensembl release 89: ENSG00000131626, ENSG00000288198 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037519 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (Aug 1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J. 14 (12): 2827–2838. doi:10.1002/j.1460-2075.1995.tb07282.x. PMC   398401 . PMID   7796809.
6. Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–15620. doi: 10.1074/jbc.273.25.15611 . PMID   9624153.
7. "Entrez Gene: PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1".
8. Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi: 10.1074/jbc.M307561200 . PMID   12923177.
9. Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC   6741975 . PMID   12629171.
10. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
11. Pulido R, Serra-Pagès C, Tang M, Streuli M (Dec 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. Bibcode:1995PNAS...9211686P. doi: 10.1073/pnas.92.25.11686 . PMC   40467 . PMID   8524829.

Further reading

• Pulido R, Serra-Pagès C, Tang M, Streuli M (1996). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–11690. Bibcode:1995PNAS...9211686P. doi: 10.1073/pnas.92.25.11686 . PMC   40467 . PMID   8524829.
• Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M (2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron. 34 (1): 39–52. doi: 10.1016/S0896-6273(02)00640-2 . PMID   11931740.
• Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–1677. doi: 10.1523/JNEUROSCI.23-05-01667.2003 . PMC   6741975 . PMID   12629171.
• Ko J, Na M, Kim S, Lee JR, Kim E (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–42385. doi: 10.1074/jbc.M307561200 . PMID   12923177.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–1450. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Serra-Pagès C, Streuli M, Medley QG (2006). "Liprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylation". Biochemistry. 44 (48): 15715–15724. doi:10.1021/bi051434f. PMC   2529169 . PMID   16313174.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.
• Hoogenraad CC, Feliu-Mojer MI, Spangler SA, Milstein AD, Dunah AW, Hung AY, Sheng M (2007). "Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development". Dev. Cell. 12 (4): 587–602. doi: 10.1016/j.devcel.2007.02.006 . PMID   17419996.

External links

• Overview of all the structural information available in the PDB for UniProt : Q13136 (Liprin-alpha-1) at the PDBe-KB .