Government and law
- Philo Hall (1886), U.S. Representative from South Dakota and 6th Attorney General of South Dakota.
- Sigurd Anderson, 19th Governor of South Dakota.
- Ben Reifel (1932), U.S. Representative from South Dakota, first Indian member of Congress.
- Francis G. Dunn (1935), Chief Justice, South Dakota Supreme Court.
- Andrew Wendell Bogue (1941), Chief Judge, United States District Court for the District of South Dakota.
- Gordon Mydland (1944), 23rd Attorney General of South Dakota.
- Richard F. Kneip (1945), 6th United States Ambassador to the Republic of Singapore and 25th Governor of South Dakota.
- William Dougherty (1954), Lieutenant Governor of South Dakota.
- Frank E. Denholm (1956), U.S. Representative from South Dakota.
- Kermit A. Sande (1964), 24th Attorney General of South Dakota.
- Tom Daschle (1969), United States Majority Leader of the United States Senate and U.S. Representative from South Dakota.
- Larry Long (1969), 29th Attorney General of South Dakota.
- Randy Seiler, 41st United States Attorney for the District of South Dakota.
- Alan Lance (1971), 31st Attorney General of Idaho, Judge of the United States Court of Appeals for Veterans Claims, and National Commander of The American Legion.
- David Gilbertson (1972), current Chief Justice, South Dakota Supreme Court.
- Mike Rounds (1976), current U.S. Senator from South Dakota and 31st Governor of South Dakota.
- Stephen Censky (1981), current United States Deputy Secretary of Agriculture.
- Carole Hillard (1982), Lieutenant Governor of South Dakota.
- Tom Nelson (1979), Mayor of the City of Lead and State Senator.
- Kristie Fiegen (1984), Chairwoman of South Dakota Public Utilities Commission.
- Gregory J. Stoltenburg (1984), current presiding judge, Third Circuit Court of South Dakota.
- Mark Salter (1990), current Associate Justice of the South Dakota Supreme Court.
- Jason Frerichs (2007), current South Dakota Senate Minority Leader.
- Kristi Noem (2011), current U.S. Representative from South Dakota and first female Governor of South Dakota.
- Charles Abourezk, current Chief Justice, Rosebud Sioux Tribe Supreme Court.
- Pam Cole, former member of the South Dakota State Senate.
