Interstate 49 (I-49) is a north–south Interstate Highway that exists in multiple segments: the original portion entirely within the state of Louisiana with an additional signed portion extending from I-220 in Shreveport to the Arkansas state line, three newer sections in Arkansas, and a new section that opened in Missouri. Its southern terminus is in Lafayette, Louisiana, at I-10 while its northern terminus is in Kansas City, Missouri, at I-435 and I-470. Portions of the remaining roadway in Louisiana, Arkansas, and Texas, which will link Kansas City with New Orleans, are in various stages of planning or construction.
U.S. Route 71 or U.S. Highway 71 is a major north–south United States highway that extends for over 1500 miles (2500 km) in the central United States. This original 1926 route has remained largely unchanged by encroaching Interstate highways. Currently, the highway's northern terminus is in International Falls, Minnesota at the Canada–US border, at the southern end of the Fort Frances-International Falls International Bridge to Fort Frances, Ontario. U.S. Route 53 also ends here. On the other side of the bridge, Trans-Canada Highway is an east–west route while Ontario Highway 71 is a north–south route. US 71's southern terminus is between Port Barre and Krotz Springs, Louisiana at an intersection with U.S. Route 190. For the entirety south of Kansas City, Missouri, US 71 runs parallel and concurrent with the existing and future Interstate 49. North of Kansas City, US 71 runs halfway between Interstate 29 and Interstate 35, which they split in the city at an interchange with Interstate 70.
U.S. Route 167 is a north-south United States Highway within the U.S. states of Louisiana and Arkansas. It runs for 500 miles (800 km) from Ash Flat, Arkansas at U.S. Route 62/US Route 412 to Abbeville, Louisiana at Louisiana Highway 14. It goes through the cities of Little Rock, Arkansas, Alexandria, Louisiana, and Lafayette, Louisiana.
Interstate 229 (I-229) is a 15-mile-long (24 km) auxiliary Interstate Highway that runs through St. Joseph, Missouri. It begins southeast of the city at I-29 and U.S. Route 71 (US 71) and travels to the northwest into the city. In St. Joseph, it runs with US 59. Just north of an interchange with US 36, the two routes travel over a one-mile-long (1.6 km) viaduct on the banks of the Missouri River. The two routes split at the north end of the viaduct. The Interstate ends at another interchange with I-29 and US 71 north of St. Joseph.
Route 66 is a fourteen-mile (21 km) long road in southwest Missouri, USA, which had previously been U.S. Route 66 for its final six years. The highway begins at Interstate 44, passes through Duenweg, Duquesne, and Joplin, then crosses into Kansas becoming K-66.
Route 86 is a highway in southwest Missouri. The eastern terminus is at U.S. Route 65 just north of Ridgedale. From there, the road crosses the Long Creek arm of Table Rock Lake and continues to Blue Eye west between the Arkansas state line on the south and Table Rock Lake on the north. This section is also in the Mark Twain National Forest, and is recommended as a scenic drive by the Missouri Department of Transportation. From Eagle Rock the road turns north to join with Route 76 at Bates Corner with which it is runs concurrent through Cassville to just east of Rocky Comfort. The road continues north and west towards Neosho, then goes further west before turning north towards Joplin where the road ends at the interchange of Interstate 44 and Route 43. Except for a short section in Neosho, the road is a two-lane highway for its entire length.
Route 59 is a highway in southwest Missouri running from Interstate 44/Interstate 49/U.S. Route 71 at Fidelity to the Arkansas state line where it continues as Highway 59. It replaced a large section of U.S. Route 71 and Alternate US 71 in sections. The first section was designated in 1960 between Lanagan and the Arkansas state line when US 71 was moved down the former Route 88. In the 1990s, US 71 was moved and upgraded to interstate standards from Neosho to Lanagan and Route 59 was extended north to Neosho. When US 71 was moved east of Joplin in the late 1990s, Alternate US 71 was deleted, and Route 59 was extended north to replace that highway. The highway was numbered after Arkansas Highway 59.
Route 76 is a highway in the west half of southern Missouri running between U.S. Route 60 and U.S. Route 63 at Willow Springs and the Oklahoma state line near Tiff City where it continues as a county road. It bypasses Branson on the Ozark Mountain High Road and is the namesake of the Branson strip, 76 Country Blvd. The road runs for its entirety through the Missouri Ozarks, and is at times very hilly and curvy.
Route 1 is a 7.253-mile-long (11.673 km) state highway in the Kansas City metropolitan area that travels from Route 210 in North Kansas City to Route 152 in Kansas City. Because of annexation, Route 1 travels to the north out of North Kansas City and enters Kansas City proper before passing through Gladstone and re-entering Kansas City.
Route 249 is a 6.162-mile-long (9.917 km), four-lane state highway in the southwestern part of the U.S. state of Missouri. It is a freeway that travels from Interstate 44/Interstate 49 (I-44/I-49) in Joplin and ending at Business I-49 in Carterville.
Route 291 is a state highway in the western part of the U.S. state of Missouri. Its southern terminus is at I-49/US 71 in Harrisonville; its northern terminus is at I-435 in Kansas City. The route was once designated as US 71 Bypass. Route 291 serves as a main arterial road and commercial strip in Liberty and Independence.
Route 150 is a highway on the south side of the Kansas City, Missouri Metro Area. It runs east from the Kansas–Missouri state border to US 50 in Lone Jack, its length totaling to around 25.6 miles.
Interstate 470 (I-470) is a 16.72-mile (26.91 km) loop of the Interstate Highway System that serves to link southeast Kansas City to Independence via Lee's Summit in Jackson County, Missouri. The western terminus of the freeway is at the Grandview Triangle interchange with I-49, I-435, U.S. Route 50 (US 50), and US 71 while the northern terminus is a cloverleaf interchange with I-70. The freeway travels west to east through southern Kansas City, curving toward the north at the Lee's Summit Municipal Airport and becoming concurrent with Route 291 as the highway travels north toward Independence.
In the US state of Iowa, Interstate 29 (I-29) is a north–south Interstate Highway which closely parallels the Missouri River. I-29 enters Iowa from Missouri near Hamburg and heads to the north-northwest through the Omaha–Council Bluffs and the Sioux City areas. It exits the state by crossing the Big Sioux River into South Dakota. For its entire distance through the state, it runs on the flat land between the Missouri River and the Loess Hills.
A total of ten special routes of U.S. Route 71 exist, and another ten previously existed.
U.S. Route 71 (US 71) is a major north–south U.S. Highway that runs from Louisiana to Canada. US 71 enters Missouri from Arkansas in the town of Jane. US 71 serves the cities of Joplin, Kansas City and St. Joseph. At noon on December 12, 2012, the section of US 71 between Pineville, Missouri and I-435 in south Kansas City was also designated as a northern extension of Interstate 49 (I-49).
Four business routes of Interstate 49 (I-49) exist, all of them within the state of Missouri. All four were once business routes of U.S. Route 71 (US 71) and were converted to business routes of I-49 on December 12, 2012, when that highway was designated in Missouri.
U.S. Route 59 (US-59) is a part of the U.S. Highway System that runs from the Mexico–US border in Laredo, Texas, as a continuation of Mexican Federal Highway 85D north to the Lancaster–Tolstoi Border Crossing on the Canada–US border, where it continues as Manitoba Highway 59. In the U.S. state of Kansas, US-59 is a main north–south highway that travels from Chetopa to Atchison.
U.S. Route 54 in Missouri is a west-east highway that starts from the Kansas state line in Nevada to the Illinois state line in Louisiana.
U.S. Route 60 (US 60) is a part of the United States Numbered Highway System that runs from Brenda, Arizona, east to Virginia Beach, Virginia. In the state of Missouri, US 60 is a main east–west highway that runs through the southern part of the state, from the Oklahoma border to the Illinois border.
I-49 BL / Route 86 in Neosho 
