NOL5A

NOP56
Identifiers
Aliases	NOP56 , NOL5A, SCA36, NOP56 ribonucleoprotein
External IDs	OMIM: 614154 MGI: 1914384 HomoloGene: 4660 GeneCards: NOP56
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p13 Start 2,652,593 bp [1] End 2,658,393 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 F1 Start 130,116,350 bp [2] End 130,121,233 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right uterine tube left uterine tube lymph node anterior pituitary spleen ganglionic eminence rectum peritoneum skin of abdomen Top expressed in blastocyst neural tube thymus morula ganglionic eminence ovary yolk sac mesencephalon bone marrow lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone methyltransferase binding protein binding snoRNA binding RNA binding cadherin binding Cellular component cytoplasm box C/D RNP complex sno(s)RNA-containing ribonucleoprotein complex small-subunit processome pre-snoRNP complex membrane nucleus nucleoplasm fibrillar center nucleolus Biological process rRNA processing rRNA modification ribosome biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10528 67134 Ensembl ENSG00000101361 ENSMUSG00000027405 UniProt O00567 Q9D6Z1 RefSeq (mRNA) NM_006392 NM_024193 RefSeq (protein) NP_006383 NP_077155 Location (UCSC) Chr 20: 2.65 – 2.66 Mb Chr 2: 130.12 – 130.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nucleolar protein 56 is a protein that in humans is encoded by the NOP56 gene. ^{[5] [6]}

Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them have not been determined. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000101361 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027405 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gautier T, Berges T, Tollervey D, et al. (Dec 1997). "Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis". Mol Cell Biol. 17 (12): 7088–98. doi:10.1128/MCB.17.12.7088. PMC   232565 . PMID   9372940.
6. "Entrez Gene: NOL5A nucleolar protein 5A (56kDa with KKE/D repeat)".

Further reading

• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Watkins NJ, Dickmanns A, Lührmann R (2003). "Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP". Mol. Cell. Biol. 22 (23): 8342–52. doi:10.1128/MCB.22.23.8342-8352.2002. PMC   134055 . PMID   12417735.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hayano T, Yanagida M, Yamauchi Y, et al. (2003). "Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome". J. Biol. Chem. 278 (36): 34309–19. doi: 10.1074/jbc.M304304200 . PMID   12777385.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID   15188402. S2CID   6773754.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Watkins NJ, Lemm I, Ingelfinger D, et al. (2005). "Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex". Mol. Cell. 16 (5): 789–98. doi:10.1016/j.molcel.2004.11.012. hdl: 11858/00-001M-0000-0012-EB89-8 . PMID   15574333.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.