Optic cup (embryology)

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Optic cup (embryology)
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Transverse section of head of chick embryo of forty-eight hours’ incubation. (Margin of optic cup labeled at upper right.)
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Optic cup and choroidal fissure seen from below, from a human embryo of about four weeks. (Edge of optic cup labeled at upper right.)
Details
Carnegie stage 13
Days36
Precursor Optic vesicles
Identifiers
Latin cupula optica; caliculus ophthalmicus
TE cup (embryology)_by_E5.14.3.4.2.2.7 E5.14.3.4.2.2.7
Anatomical terminology

During embryonic development of the eye, the outer wall of the bulb of the optic vesicles becomes thickened and invaginated, and the bulb is thus converted into a cup, the optic cup (or ophthalmic cup), consisting of two strata of cells. These two strata are continuous with each other at the cup margin, which ultimately overlaps the front of the lens and reaches as far forward as the future aperture of the pupil.

The optic cup is part of the diencephalon and gives rise to the retina of the eye.

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The optic vesicles project toward the sides of the head, and the peripheral part of each expands to form a hollow bulb, while the proximal part remains narrow and constitutes the optic stalk.

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The eyes begin to develop as a pair of diverticula (pouches) from the lateral aspects of the forebrain. These diverticula make their appearance before the closure of the anterior end of the neural tube; after the closure of the tube around the 4th week of development, they are known as the optic vesicles. Previous studies of optic vesicles suggest that the surrounding extraocular tissues – the surface ectoderm and extraocular mesenchyme – are necessary for normal eye growth and differentiation.

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The globe of the eye, or bulbus oculi, is the frontmost sensory organ of the human ocular system, going from the cornea at the front, to the anterior part of the optic nerve at the back. More simply, the eyeball itself, as well as the ganglion cells in the retina that eventually transmit visual signals through the optic nerve. A hollow structure, the bulbus oculi is composed of a wall enclosing a cavity filled with fluid with three coats: the sclera, choroid, and the retina. Normally, the bulbus oculi is bulb-like structure. However, the bulbus oculi is not completely spherical. Its anterior surface, transparent and more curved, is known as the cornea of the bulbus oculi.

References

PD-icon.svgThis article incorporates text in the public domain from page 1001 of the 20th edition of Gray's Anatomy (1918)