Peter Doherty | |
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Born | Peter Charles Doherty 15 October 1940 (age 82) [1] Brisbane, Queensland, Australia |
Nationality | Australian |
Alma mater |
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Known for | Major histocompatibility complex |
Awards | Paul Ehrlich and Ludwig Darmstaedter Prize (1983) Nobel Prize in Physiology or Medicine (1996) Australian of the Year (1997) Leeuwenhoek Lecture (1999) [2] |
Scientific career | |
Fields | Medicine Immunology |
Institutions | John Curtin School of Medical Research Australian National University |
Thesis | Studies in the experimental pathology of louping-ill encephalitis (1970) |
Doctoral advisor | G. L. Montgomery J. T. Stamp [3] |
Peter Charles Doherty AC FRS FMedSci (born 15 October 1940) [1] is an Australian immunologist and Nobel laureate. [4] He received the Albert Lasker Award for Basic Medical Research in 1995, the Nobel Prize in Physiology or Medicine jointly with Rolf M. Zinkernagel [5] in 1996 and was named Australian of the Year in 1997. [6] In the Australia Day Honours of 1997, he was named a Companion of the Order of Australia for his work with Zinkernagel. [7] He is also a National Trust Australian Living Treasure. [8] In 2009 as part of the Q150 celebrations, Doherty's immune system research was announced as one of the Q150 Icons of Queensland for its role as an iconic "innovation and invention". [9]
Peter Charles Doherty was born in the Brisbane suburb of Sherwood on 15 October 1940, to Eric Charles Doherty and Linda Doherty (née Byford). [10] [11] He grew up in Oxley, [12] and attended Indooroopilly State High School (which now has a lecture theatre named after him).
After receiving his bachelor's degree in veterinary science in 1962 from the University of Queensland, he was a rural veterinary officer for the Queensland Department of Agriculture and Stock before taking up laboratory-based work at the Department's Animal Research Institute. [13] There he met microbiology graduate Penelope Stephens and they were married in 1965. [13] Doherty received his master's degree in veterinary science in 1966 from the University of Queensland. [14]
He obtained his PhD in pathology [15] in 1970 from the University of Edinburgh, Scotland, [3] then returned to Australia to continue his research at the John Curtin School of Medical Research within the Australian National University in Canberra.
Doherty's research focuses [16] [17] on the immune system and his Nobel Prize work described how the body's immune cells protect against viruses. He and Rolf Zinkernagel, the co-recipient of the 1996 Nobel Prize in Physiology or Medicine, discovered how T cells recognise their target antigens in combination with major histocompatibility complex (MHC) proteins. [18]
Viruses infect host cells and reproduce inside them. Killer T-cells destroy those infected cells so that the viruses cannot reproduce. Zinkernagel and Doherty discovered that, in order for killer T cells to recognise infected cells, they had to recognise two molecules on the surface of the cell – not only the virus antigen, but also a molecule of the major histocompatibility complex (MHC). This recognition was done by a T-cell receptor on the surface of the T cell. The MHC was previously identified as being responsible for the rejection of incompatible tissues during transplantation. Zinkernagel and Doherty discovered that the MHC was responsible for the body fighting meningitis viruses too. [19]
Doherty was elected a Fellow of the Royal Society (FRS) in 1987. [2] In 1997, he received the Golden Plate Award of the American Academy of Achievement. [20] He is the patron of the eponymous Peter Doherty Institute for Infection and Immunity (Doherty Institute), a joint venture between the University of Melbourne and Melbourne Health. It houses a group of infection and immunology experts, including Director Professor Sharon Lewin, who are charged with leading the battle against infectious diseases in humans. This became operational in 2014. [21] He became an Honorary Fellow of the Academy of Medical Sciences (FMedSci) in 2015. [22] In the same year he was elected Fellow of the Australian Academy of Health and Medical Sciences (FAHMS). [23] In April 2017 he was inducted as a Fellow of the Royal Society of Victoria (FRSV). [24]
John Monash Science School, [25] Moreton Bay Boys College, [26] and Murrumba State Secondary College [27] each have a house named after him.
As of 2021 [update] , Peter Doherty and his wife Penny live in Melbourne. [29] They have two sons, Michael, a neurologist working in the United States, [30] and James, a Melbourne-based barrister, [13] and six grandchildren. [31]
Doherty currently[ when? ] spends three months of the year conducting research at St. Jude Children's Research Hospital in Memphis, Tennessee, where he is a faculty member at the University of Tennessee Health Science Center through the College of Medicine. [32] For the other 9 months of the year, he works in the Department of Microbiology and Immunology at the University of Melbourne, Victoria.
In immunology, an antigen (Ag) is a molecule, moiety, foreign particulate matter, or an allergen, such as pollen, that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response.
The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism's own healthy tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli. The adaptive immune system provides a tailored response to each stimulus by learning to recognize molecules it has previously encountered. Both use molecules and cells to perform their functions.
Histocompatibility, or tissue compatibility, is the property of having the same, or sufficiently similar, alleles of a set of genes called human leukocyte antigens (HLA), or major histocompatibility complex (MHC). Each individual expresses many unique HLA proteins on the surface of their cells, which signal to the immune system whether a cell is part of the self or an invading organism. T cells recognize foreign HLA molecules and trigger an immune response to destroy the foreign cells. Histocompatibility testing is most relevant for topics related to whole organ, tissue, or stem cell transplants, where the similarity or difference between the donor's HLA alleles and the recipient's triggers the immune system to reject the transplant. The wide variety of potential HLA alleles lead to unique combinations in individuals and make matching difficult.
Rolf Martin Zinkernagel is a professor of experimental immunology at the University of Zurich. Along with Peter C. Doherty, he shared the 1996 Nobel Prize in Physiology or Medicine for the discovery of how the immune system recognizes virus-infected cells.
Jacques Francis Albert Pierre Miller AC FRS FAA is a French-Australian research scientist. He is known for having discovered the function of the thymus and for the identification, in mammalian species of the two major subsets of lymphocytes and their function.
Brett John Mason is a former Australian politician and a Liberal/Liberal National of Queensland member of the Australian Senate from 1 July 1999 to 15 April 2015, representing the state of Queensland. Mason was the Australian Ambassador to the Netherlands from September 2015 to August 2018.
Kenneth Stanley Inglis, was an Australian historian.
William Leonard Gammage is an Australian academic historian, adjunct professor and senior research fellow at the Humanities Research Centre of the Australian National University (ANU). Gammage was born in Orange, New South Wales, went to Wagga Wagga High School and then to ANU. He was on the faculty of the University of Papua New Guinea and the University of Adelaide. He is a fellow of the Australian Academy of Social Sciences and deputy chair of the National Museum of Australia.
Gordon Leslie Ada AO, FAA was an Australian biochemist best known for his seminal contributions to virology and immunology and his long leadership of the Department of Microbiology at the John Curtin School of Medical Research at the Australian National University, where Peter C. Doherty and Rolf Zinkernagel performed their Nobel winning research in his department. Both Zinkernagel and Doherty held him in high regard, and he was invited by them to attend the Nobel award ceremony and dinner in Stockholm.
The John Curtin School of Medical Research (JCSMR) is an Australian multidisciplinary translational medical research institute and postgraduate education centre that forms part of the Australian National University (ANU) in Canberra. The school was founded in 1948 as a result of the vision of Nobel Laureate Sir Howard Florey and was named in honour of Australia's World War II Prime Minister John Curtin, who had died in office a few years earlier.
Emil Raphael Unanue was a Cuban-American immunologist and Paul & Ellen Lacy Professor Emeritus at Washington University School of Medicine. He is a member of the National Academy of Sciences, the American Academy of Arts and Sciences and the Institute of Medicine. He previously served as chair of the National Academy of Sciences Section of Microbiology and Immunology.
The Ian Constable Lecture is an annual lecture given in Perth, Western Australia.
Ralph Marvin Steinman was a Canadian physician and medical researcher at Rockefeller University, who in 1973 discovered and named dendritic cells while working as a postdoctoral fellow in the laboratory of Zanvil A. Cohn, also at Rockefeller University. Steinman was one of the recipients of the 2011 Nobel Prize in Physiology or Medicine.
The Australian College of Educators (ACE) is an Australian national professional association for educators. Membership is open to all professional educators working in the early childhood, school, and tertiary education sectors, as well as to education researchers and managers. The College advocates for its members in seeking improvements in the status of the education profession.
Gabrielle T. Belz is an Australian molecular immunologist and viral immunologist. She is a faculty member of the Walter and Eliza Hall Institute of Medical Research, within the Molecular Immunology division. Belz has made important contributions to the understanding of immune system function, especially in relation to the molecular and cellular signalling pathways of immune response to viruses. Her research has focused on understanding the signals that drive the initial development of protective immunity against pathogen infections, such as influenza and herpes viruses. This includes research into how cytotoxic T cells recognise and remove virally-infected cells from the body following infection. Research into the description of the specific factors and response during infection will contribute towards the long-term development of vaccines for infectious disease, and the development of better treatments for autoimmune diseases.
Margaret Sabine (1928–2011) was the pioneering virologist for Australian veterinary schools. She conducted studies on viruses in cats and horses, with her characterisation of different equine viruses being her most significant scientific contribution. Other achievements include becoming head of the department of veterinary pathology and bacteriology, being chairwoman of the NSW Animal Welfare Advisory Council, an honorary Veterinary Science degree at the University of Sydney, and being a co-discoverer of viral interference.
Gene Martin Shearer is an American immunologist who works at the National Institutes of Health (NIH). He first achieved fame for his discovery in 1974 that T lymphocytes recognized chemically modified surface antigens only in the context of self major histocompatibility complex (MHC) encoded molecules, identifying the central feature of antigen recognition by T lymphocytes known as MHC restriction. His discovery of MHC restriction using chemically modified surface antigens was simultaneous with the discovery of MHC restricted T lymphocyte recognition of virus infected cells by Rolf Zinkernagel and Peter Doherty, who received the 1996 Nobel Prize in Physiology or Medicine.
The Buntine Oration is a biennial invited presentation and speech made at the conference of the Australian College of Educators (ACE). It was established in 1960 by the four children of Dr Walter Murray Buntine who survived him – Dr R. M. Buntine, Dr M. A. Buntine, Dr R. D. Buntine, and Mrs. D. M. G. Wilson – in his memory. The inaugural oration was given by Peter Karmel in 1962 at the third annual ACE conference and the most recent was in 2008.
Laura K. Mackay is an internationally-recognised immunologist, Professor of Immunology at the University of Melbourne and a Laboratory Head at the Peter Doherty Institute for Infection and Immunity.
This article incorporates text by Royal Society available under the CC BY 4.0 license.