Philippe Grandjean (professor)

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Philippe Grandjean
Philippe Adam Grandjean
Born (1950-03-01) 1 March 1950 (age 73) [1]
Nationality Danish
Alma mater University of Copenhagen
Known forResearch into the effects of toxic chemicals on the health of children
Scientific career
Fields Environmental health
Institutions University of Southern Denmark
Harvard School of Public Health
Thesis Widening perspectives of lead toxicity  (1979)

Philippe Grandjean (born 1 March 1950) is a Danish scientist working in environmental medicine. He is the head of the Environmental Medicine Research Unit at the University of Southern Denmark [2] and adjunct professor of environmental health at the Harvard School of Public Health. [3] Grandjean is also co-founder and co-editor-in-chief of the journal Environmental Health , and consultant for the National Board of Health in Denmark. [4] [5] He is known for his research into the developmental toxicity and adverse effects of certain environmental chemicals to which children are commonly exposed. [6] [7]

Contents

Life, education and career

Born in Denmark in 1950, his interest in environmental toxins began as a teenager watching birds and realizing that they were threatened by pesticides. [8] Grandjean obtained his MD in environmental medicine from the University of Copenhagen in 1974 [9] and his PhD in 1979. [3] He began his career conducting field work into mercury poisoning and Minamata disease after seeing a woman with the disease on TV in 1972. This experience led him to spend his career researching neurotoxic substances. [10] [11] Since 1982, Grandjean has been a professor at the University of Southern Denmark [9] and today he also heads their Environmental Medicine Research Unit. [2] From 1994 to 2002 he was adjunct professor at Boston University [9] and since 2003 he has been adjunct professor at Harvard School of Public Health. [3] In 2002, he co-founded the journal Environmental Health [4] and today he is the co-editor-in-chief, along with David Ozonoff of Boston University School of Public Health. [5]

Grandjean has authored more than 500 scientific publications and his book Only One Chance: How Environmental Pollution Impairs Brain Development – and How to Protect the Brains of the Next Generation (Danish edition: Kemi på hjernen – går ud over enhver forstand) was published by Oxford University Press in 2013 ( ISBN   978-0199985388). [4]

Research

Grandjean is known for conducting considerable research into the health effects of mercury in fish, and has spoken out for the maximum levels allowed by the EPA to be lowered by 50%. [12]

Together with Philip Landrigan, Grandjean wrote about chemicals, including certain fluorinated compounds, certain heavy metals, DDT, PCB and toluene, found in the environment that they described as harmful to the neurodevelopment of children and fetuses. [13] [14] [7] [15] [16] Landrigan and Grandjean proposed the implementation of a global prevention strategy to reduce children's exposure to such chemicals, and encouraged lawmakers not to assume that untested chemicals were "safe to brain development." [6] [17]

Related Research Articles

<span class="mw-page-title-main">Neurotoxin</span> Toxin harmful to nervous tissue

Neurotoxins are toxins that are destructive to nerve tissue. Neurotoxins are an extensive class of exogenous chemical neurological insults that can adversely affect function in both developing and mature nervous tissue. The term can also be used to classify endogenous compounds, which, when abnormally contacted, can prove neurologically toxic. Though neurotoxins are often neurologically destructive, their ability to specifically target neural components is important in the study of nervous systems. Common examples of neurotoxins include lead, ethanol, glutamate, nitric oxide, botulinum toxin, tetanus toxin, and tetrodotoxin. Some substances such as nitric oxide and glutamate are in fact essential for proper function of the body and only exert neurotoxic effects at excessive concentrations.

<span class="mw-page-title-main">Mercury poisoning</span> Poisoning caused by mercury chemicals

Mercury poisoning is a type of metal poisoning due to exposure to mercury. Symptoms depend upon the type, dose, method, and duration of exposure. They may include muscle weakness, poor coordination, numbness in the hands and feet, skin rashes, anxiety, memory problems, trouble speaking, trouble hearing, or trouble seeing. High-level exposure to methylmercury is known as Minamata disease. Methylmercury exposure in children may result in acrodynia in which the skin becomes pink and peels. Long-term complications may include kidney problems and decreased intelligence. The effects of long-term low-dose exposure to methylmercury are unclear.

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Pesticide residue refers to the pesticides that may remain on or in food after they are applied to food crops. The maximum allowable levels of these residues in foods are often stipulated by regulatory bodies in many countries. Regulations such as pre-harvest intervals also often prevent harvest of crop or livestock products if recently treated in order to allow residue concentrations to decrease over time to safe levels before harvest. Exposure of the general population to these residues most commonly occurs through consumption of treated food sources, or being in close contact to areas treated with pesticides such as farms or lawns.

Thiomersal is a mercury compound which is used as a preservative in some vaccines. Anti-vaccination activists promoting the incorrect claim that vaccination causes autism have asserted that the mercury in thiomersal is the cause. There is no scientific evidence to support this claim. The idea that thiomersal in vaccines might have detrimental effects originated with anti-vaccination activists and was sustained by them and especially through the action of plaintiffs' lawyers.

<span class="mw-page-title-main">Herbert Needleman</span> American researcher

Herbert Leroy Needleman researched the neurodevelopmental damage caused by lead poisoning. He was a pediatrician, child psychiatrist, researcher and professor at the University of Pittsburgh, an elected member of the Institute of Medicine, and the founder of the Alliance to End Childhood Lead Poisoning. Dr. Needleman played a key role in securing some of the most significant environmental health protections achieved during the 20th century, which resulted in a fivefold reduction in the prevalence of lead poisoning among children in the United States by the early 1990s. Despite engendering strong resistance from lead-related industries, which made him the target of frequent attacks, Needleman persisted in campaigning to educate stakeholders, including parents and government panels, about the dangers of lead poisoning. Needleman has been credited with having played a key role in triggering environmental safety measures that have reduced average blood lead levels by an estimated 78 percent between 1976 and 1991. He died in Pittsburgh in 2017.

<span class="mw-page-title-main">Manuel Casanova</span> American professor

Manuel F. Casanova is the SmartState Endowed Chair in Childhood Neurotherapeutics and a professor of Biomedical Sciences at the University of South Carolina School of Medicine Greenville. He is a former Gottfried and Gisela Kolb Endowed Chair in Outpatient Psychiatry and a Professor of Anatomical Sciences and Neurobiology at the University of Louisville.

Health can affect intelligence in various ways. Conversely, intelligence can affect health. Health effects on intelligence have been described as being among the most important factors in the origins of human group differences in IQ test scores and other measures of cognitive ability. Several factors can lead to significant cognitive impairment, particularly if they occur during pregnancy and childhood when the brain is growing and the blood–brain barrier of the child is less effective. Such impairment may sometimes be permanent, sometimes be partially or wholly compensated for by later growth.

Joanna Sigfred Fowler is a scientist emeritus at the U.S. Department of Energy's Brookhaven National Laboratory in New York. She served as professor of psychiatry at Mount Sinai School of Medicine and director of Brookhaven's Radiotracer Chemistry, Instrumentation and Biological Imaging Program. Fowler studied the effect of disease, drugs, and aging on the human brain and radiotracers in brain chemistry. She has received many awards for her pioneering work, including the National Medal of Science.

<span class="mw-page-title-main">Devra Davis</span> American epidemiologist and writer

Devra Lee Davis is an American epidemiologist, toxicologist, and author of three books about environmental hazards. She was founding director of the Center for Environmental Oncology at the University of Pittsburgh Cancer Institute, and is a former professor of epidemiology at University of Pittsburgh Graduate School of Public Health. She has served on several governmental and non-governmental organizations, conducting research and advocacy into effects of pesticides, asbestos, and wireless radiation on human health, especially cancers.

<span class="mw-page-title-main">Environmental epidemiology</span>

Environmental epidemiology is a branch of epidemiology concerned with determining how environmental exposures impact human health. This field seeks to understand how various external risk factors may predispose to or protect against disease, illness, injury, developmental abnormalities, or death. These factors may be naturally occurring or may be introduced into environments where people live, work, and play.

UCL Neuroscience is a research domain that encompasses the breadth of neuroscience research activity across University College London's (UCL) School of Life and Medical Sciences. The domain was established in January 2008, to coordinate neuroscience activity across the many UCL departments and institutes in which neuroscience research takes place. In 2014, the Nobel Prize in Physiology or Medicine was awarded to the UCL neuroscientist John O'Keefe. In two consecutive years 2017 and 2018, the Brain Prize, the world's most valuable prize for brain research at €1m, was awarded to UCL neuroscientists Peter Dayan, Ray Dolan, John Hardy, and Bart De Strooper.

<span class="mw-page-title-main">Philip J. Landrigan</span> American epidemiologist and pediatrician

Philip John Landrigan, is an American epidemiologist and pediatrician and one of the world's leading advocates of children's health.

<span class="mw-page-title-main">Mercury in fish</span>

The presence of mercury in fish is a health concern for people who eat them, especially for women who are or may become pregnant, nursing mothers, and young children. Fish and shellfish concentrate mercury in their bodies, often in the form of methylmercury, a highly toxic organomercury compound. This element is known to bioaccumulate in humans, so bioaccumulation in seafood carries over into human populations, where it can result in mercury poisoning. Mercury is dangerous to both natural ecosystems and humans because it is a metal known to be highly toxic, especially due to its neurotoxic ability to damage the central nervous system.

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Hurair Vasken Aposhian was a Ph.D. toxicologist and an emeritus professor of molecular and cell biology at the University of Arizona, a post he held beginning in 1975. He is also a former professor of pharmacology at the medical school at said university. He received his bachelor's degree in chemistry, at Brown University, 1948. He received a master's degree and a PhD in physiological chemistry at the University of Rochester, where he published some scientific studies about the synthesis of isoalloxazine ring-containing compounds. He did a postdoctoral with Nobel Laureate Arthur Kornberg in the department of biochemistry at Stanford University School of Medicine. He has done sabbatical scholar-in-residence at MIT and at the University of California at San Diego. He is best known for his pioneering work on Succimer and Unithiol in the treatment of arsenic, mercury, lead and other heavy metals leading to FDA approval of succimer in childhood lead poisoning at levels over 40 ug/dl. Previous posts he had held include at Vanderbilt, Tufts University, and the University of Maryland. His views about mercury in vaccines and in dental amalgams go against the consensus of the medical community and are controversial.

Environmental Health is a peer-reviewed medical journal established in 2002 and published by BioMed Central. It covers research in all areas of environmental and occupational medicine. The editors-in-chief are Philippe Grandjean and David Ozonoff. According to the Journal Citation Reports, the journal has a 2019 impact factor of 4.690.

Daniel H. Geschwind is the Gordon and Virginia MacDonald Distinguished Professor of Human Genetics, Neurology and Psychiatry at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). He also directs the UCLA Neurogenetics Program and the UCLA Center for Autism Research and Treatment (CART), and holds the Gordon and Virginia MacDonald Distinguished Chair of Human Genetics there. Since March 1, 2016, he has served as the Senior Associate Dean and Associate Vice Chancellor for Precision Medicine at UCLA. His brother, Michael Geschwind, is also a professor of neurology, and behavioral neurology pioneer Norman Geschwind is his father's first cousin.

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References

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  3. 1 2 3 "Philippe Grandjean". Harvard T.H. Chan School of Public Health . Retrieved 11 December 2016.
  4. 1 2 3 Patton, P. (16 April 2014). "Dr. Philippe Grandjean on Chemical Brain Drain: How the Next Generation's Brain Functions are Endangered by EDCs and Other Environmental Chemicals". Collaborative on Health and the Environment. Retrieved 10 December 2016.
  5. 1 2 "Environmental Health". BioMed Central. Retrieved 10 December 2016.
  6. 1 2 Weintraub, Karen (14 February 2014). "Researchers warn of chemical impacts on children". USA Today . Retrieved 22 February 2014.
  7. 1 2 Hamilton, Jon (24 January 2012). "Common Chemicals Could Make Kids' Vaccines Less Effective". NPR . Retrieved 22 February 2014.
  8. Andersen, P.N. (23 March 2016). "Professor: Fra det øjeblik man beslutter en graviditet, skal man holde sig fra ikke-økologisk frugt". Natur & Miljø. Retrieved 10 December 2016.
  9. 1 2 3 "Philippe Grandjean - CV". University of Southern Denmark . Retrieved 10 December 2016.
  10. Main, Douglas (26 September 2013). "The surprising source of most mercury pollution: Gold mining". NBC News . Retrieved 22 February 2014.
  11. Williams, Florence (7 December 2013). "How We're Destroying Our Kids' Brains". Mother Jones . Retrieved 22 February 2014.
  12. Weise, Elizabeth (19 September 2012). "Take tuna off school menus, group says". USA Today . Retrieved 24 February 2014.
  13. Grandjean, P; Landrigan, PJ (December 2006). "Developmental neurotoxicity of industrial chemicals". The Lancet. 368 (9553): 2167–2178. doi:10.1016/S0140-6736(06)69665-7. PMID   17174709. S2CID   12795774.
  14. Boyles, Salynn (7 November 2006). "A 'Silent Pandemic' Of Brain Disorders". CBS News . Retrieved 26 March 2014.
  15. Grandjean, P.; Andersen, E. W.; Budtz-Jørgensen, E.; Nielsen, F.; Mølbak, K. R.; Weihe, P.; Heilmann, C. (2012). "Serum Vaccine Antibody Concentrations in Children Exposed to Perfluorinated Compounds". JAMA. 307 (4): 391–397. doi:10.1001/jama.2011.2034. PMC   4402650 . PMID   22274686.
  16. Hamblin, James (18 March 2014). "The Toxins That Threaten Our Brains". The Atlantic . Retrieved 26 March 2014.
  17. Grandjean, P.; Landrigan, P. J. (2014). "Neurobehavioural effects of developmental toxicity". The Lancet Neurology. 13 (3): 330–8. doi:10.1016/S1474-4422(13)70278-3. PMC   4418502 . PMID   24556010.