RGS10

RGS10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DLR, 2I59, 2IHB
Identifiers
Aliases	RGS10 , regulator of G protein signaling 10
External IDs	OMIM: 602856 MGI: 1915115 HomoloGene: 37710 GeneCards: RGS10
Gene location (Human)
Chr.	Chromosome 10 (human)
End	119,542,719 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	128,020,482 bp
RNA expression pattern
	Top expressed in
	monocyte; ; thymus; ; cancellous bone; ; periodontal fiber; ; blood; ; lymph node; ; appendix; ; rectum; ; bone marrow; ; smooth muscle tissue;
	Top expressed in
	blood; ; thymus; ; spermatid; ; spermatocyte; ; spinal ganglia; ; spleen; ; nucleus accumbens; ; globus pallidus; ; dorsal tegmental nucleus; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity ; G-protein alpha-subunit binding ; protein binding ; GTPase activity ;
Cellular component	cytosol ; plasma membrane ; nucleus ; cytoplasm ; axon terminus ; neuronal cell body ; dendritic spine ;
Biological process	G protein-coupled acetylcholine receptor signaling pathway ; positive regulation of GTPase activity ; negative regulation of signal transduction ; regulation of G protein-coupled receptor signaling pathway ; response to amphetamine ; G protein-coupled receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	6001
	67865
	ENSG00000148908
	ENSMUSG00000030844
	O43665
	Q9CQE5
	NM_002925 ; NM_001005339
	NM_026418
	NP_001005339 ; NP_002916
	NP_080694
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Regulator of G-protein signaling 10 is a protein that in humans is encoded by the RGS10 gene.^[5]^[6]

Function

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.^[6]

Interactions

RGS10 has been shown to interact with SAP18 ^[7] and GNAI3.^[5]

Related Research Articles

Regulator of G protein signaling 4 also known as RGP4 is a protein that in humans is encoded by the RGS4 gene. RGP4 regulates G protein signaling.

Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene. It is part of a larger family of RGS proteins that control signalling through G-protein coupled receptors (GPCR).

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.

GIPC PDZ domain containing family, member 1 (GIPC1) is a protein that in humans is encoded by the GIPC1 gene. GIPC was originally identified as it binds specifically to the C terminus of RGS-GAIP, a protein involved in the regulation of G protein signaling. GIPC is an acronym for "GAIP Interacting Protein C-terminus". RGS proteins are "Regulators of G protein Signaling" and RGS-GAIP is a "GTPase Activator protein for Gαi/Gαq", which are two major subtypes of Gα proteins. The human GIPC1 molecule is 333 amino acids or about 36 kDa in molecular size and consists of a central PDZ domain, a compact protein module which mediates specific protein-protein interactions. The RGS-GAIP protein interacts with this domain and many other proteins interact here or at other parts of the GIPC1 molecule. As a result, GIPC1 was independently discovered by several other groups and has a variety of alternate names, including synectin, C19orf3, RGS19IP1 and others. The GIPC1 gene family in mammals consisting of three members, so the first discovered, originally named GIPC, is now generally called GIPC1, with the other two being named GIPC2 and GIPC3. The three human proteins are about 60% identical in protein sequence. GIPC1 has been shown to interact with a variety of other receptor and cytoskeletal proteins including the GLUT1 receptor, ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4, SEMA4C/semaphorin-4 and HTLV-I Tax. The general function of GIPC family proteins therefore appears to be mediating specific interactions between proteins involved in G protein signaling and membrane translocation.

Guanine nucleotide-binding protein G(z) subunit alpha is a protein that in humans is encoded by the GNAZ gene.

Regulator of G-protein signaling 16 is a protein that in humans is encoded by the RGS16 gene.

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.

Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.

Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene.

Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.

Regulator of G-protein signaling 8 is a protein that in humans is encoded by the RGS8 gene.

Regulator of G-protein signalling 9, also known as RGS9, is a human gene, which codes for a protein involved in regulation of signal transduction inside cells. Members of the RGS family, such as RGS9, are signaling proteins that suppress the activity of G proteins by promoting their deactivation.[supplied by OMIM]

Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.

Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene.

Regulator of G-protein signaling 13 (RGS13) is a protein that in humans is encoded by the RGS13 gene.

Regulator of G-protein signaling 17 is a protein that in humans is encoded by the RGS17 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148908 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030844 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Hunt TW, Fields TA, Casey PJ, Peralta EG (Sep 1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature. 383 (6596): 175–7. Bibcode:1996Natur.383..175H. doi:10.1038/383175a0. PMID 8774883. S2CID 4318445.
1 2 "Entrez Gene: RGS10 regulator of G-protein signalling 10".
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

Popov S, Yu K, Kozasa T, Wilkie TM (Jul 1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro". Proceedings of the National Academy of Sciences of the United States of America. 94 (14): 7216–20. Bibcode:1997PNAS...94.7216P. doi: 10.1073/pnas.94.14.7216 . PMC 23796 . PMID 9207071.
Tu Y, Wang J, Ross EM (Nov 1997). "Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits". Science. 278 (5340): 1132–5. doi:10.1126/science.278.5340.1132. PMID 9353196.
Tu Y, Popov S, Slaughter C, Ross EM (Dec 1999). "Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10". The Journal of Biological Chemistry. 274 (53): 38260–7. doi: 10.1074/jbc.274.53.38260 . PMID 10608901.
Popov SG, Krishna UM, Falck JR, Wilkie TM (Jun 2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity". The Journal of Biological Chemistry. 275 (25): 18962–8. doi: 10.1074/jbc.M001128200 . PMID 10747990.
Chatterjee TK, Fisher RA (Aug 2000). "Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs". The Journal of Biological Chemistry. 275 (31): 24013–21. doi: 10.1074/jbc.M002082200 . PMID 10791963.
Burgon PG, Lee WL, Nixon AB, Peralta EG, Casey PJ (Aug 2001). "Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10)". The Journal of Biological Chemistry. 276 (35): 32828–34. doi: 10.1074/jbc.M100960200 . PMID 11443111.
Gagnon AW, Murray DL, Leadley RJ (Jul 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling. 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952.
Castro-Fernández C, Conn PM (Jun 2002). "Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus". Molecular and Cellular Endocrinology. 191 (2): 149–56. doi:10.1016/S0303-7207(02)00082-5. PMID 12062898. S2CID 36812170.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Lee HK, Rhee KH, Kim CW, Hwang KY, Kim EE (Sep 2005). "Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3". Acta Crystallographica Section F. 61 (Pt 9): 831–3. doi:10.1107/S1744309105023602. PMC 1978115 . PMID 16511171.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000148908 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030844 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8774883-5] 1 2 Hunt TW, Fields TA, Casey PJ, Peralta EG (Sep 1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature. 383 (6596): 175–7. Bibcode:1996Natur.383..175H. doi:10.1038/383175a0. PMID 8774883. S2CID 4318445.

[entrez-6] 1 2 "Entrez Gene: RGS10 regulator of G-protein signalling 10".

[pmid17353931-7] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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RGS10

Contents

Function

Interactions

Related Research Articles

References

Further reading