RGS11

RGS11
Identifiers
Aliases	RGS11 , RS11, regulator of G-protein signaling 11, regulator of G protein signaling 11
External IDs	OMIM: 603895 MGI: 1354739 HomoloGene: 77719 GeneCards: RGS11
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 268,301 bp [1] End 275,980 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A3.3 Start 26,421,925 bp [2] End 26,430,298 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary cingulate gyrus tibial nerve amygdala Brodmann area 9 nucleus accumbens caudate nucleus right coronary artery putamen hypothalamus Top expressed in superior frontal gyrus morula islet of Langerhans adrenal gland stomach primary motor cortex nucleus accumbens respiratory epithelium olfactory epithelium cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G-protein beta-subunit binding GTPase activator activity GTPase activity Cellular component cytoplasm plasma membrane protein-containing complex intracellular anatomical structure Biological process G protein-coupled receptor signaling pathway negative regulation of signal transduction intracellular signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8786 50782 Ensembl ENSG00000076344 ENSMUSG00000024186 UniProt O94810 Q9Z2H1 RefSeq (mRNA) NM_001286485 NM_001286486 NM_003834 NM_183337 NM_001081069 RefSeq (protein) NP_001273414 NP_001273415 NP_003825 NP_899180 NP_001074538 Location (UCSC) Chr 16: 0.27 – 0.28 Mb Chr 17: 26.42 – 26.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene. ^{[5] [6]}

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000076344 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024186 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc Natl Acad Sci U S A. 95 (22): 13307–12. Bibcode:1998PNAS...9513307S. doi: 10.1073/pnas.95.22.13307 . PMC   23793 . PMID   9789084.
6. "Entrez Gene: RGS11 regulator of G-protein signalling 11".

Further reading

• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16" (PDF). Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi: 10.1038/nature03187 . PMID   15616553. S2CID   4362044.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID   11829488. S2CID   16065132.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi: 10.1093/hmg/10.4.339 . PMID   11157797.
• Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. Bibcode:1999PNAS...96.6489S. doi: 10.1073/pnas.96.11.6489 . PMC   26909 . PMID   10339615.
• Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997). "Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain". J. Neurosci. 17 (20): 8024–37. doi:10.1523/JNEUROSCI.17-20-08024.1997. PMC   6793903 . PMID   9315921.