RGS18

RGS18
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DLV, 2JM5, 2OWI
Identifiers
Aliases	RGS18 , RGS13, regulator of G-protein signaling 18, regulator of G protein signaling 18
External IDs	OMIM: 607192 MGI: 1927498 HomoloGene: 11281 GeneCards: RGS18
Gene location (Human)
Chr.	Chromosome 1 (human)
End	192,185,815 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	144,651,173 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; cancellous bone; ; bone marrow; ; bone marrow cells; ; appendix; ; spleen; ; right lung; ; gallbladder; ; palpebral conjunctiva;
	Top expressed in
	blood; ; dermis; ; spleen; ; bone marrow; ; body of femur; ; abdominal wall; ; carotid body; ; right lung; ; right lung lobe; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity ; protein binding ; GTPase activity ;
Cellular component	cytoplasm ; plasma membrane ;
Biological process	G protein-coupled receptor signaling pathway ; positive regulation of GTPase activity ; negative regulation of signal transduction ; regulation of G protein-coupled receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	64407
	64214
	ENSG00000150681
	ENSMUSG00000026357
	Q9NS28
	Q99PG4
	NM_130782
	NM_022881
	NP_570138
	NP_075019
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 13, 2022

Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.^[5]^[6]

Function

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[6]

Clinical significance

Several RGS18 alleles that result in reduced RGS18 expression are associated with the development of atherosclerosis.^[7] Two single nucleotide polymorphisms in the RGS18 gene that interfere with binding of GATA1 and NFE2 transcription factors result in decreased expression of RGS18. RSG18 Knockout mice display an exaggerated platelet reactivity which in turn increases risk of developing atherosclerosis. A minor allele of RSG18 is associated with the appearance of thrombotic phenomena in a cohort of European-American and African-American patients.^[7]

Interactions

RGS18 has been shown to interact with GNAI3.^[8]^[9]

Related Research Articles

Regulator of G protein signaling 4 also known as RGP4 is a protein that in humans is encoded by the RGS4 gene. RGP4 regulates G protein signaling.

Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene. It is part of a larger family of RGS proteins that control signalling through G-protein coupled receptors (GPCR).

Guanine nucleotide-binding protein G(q) subunit alpha is a protein that in humans is encoded by the GNAQ gene. Together with GNA11, it functions as a Gq alpha subunit.

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.

Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene.

Guanine nucleotide-binding protein G(z) subunit alpha is a protein that in humans is encoded by the GNAZ gene.

Regulator of G-protein signaling 16 is a protein that in humans is encoded by the RGS16 gene.

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.

Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.

Regulator of G-protein signaling 10 is a protein that in humans is encoded by the RGS10 gene.

Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene.

Regulator of G-protein signalling 9, also known as RGS9, is a human gene, which codes for a protein involved in regulation of signal transduction inside cells. Members of the RGS family, such as RGS9, are signaling proteins that suppress the activity of G proteins by promoting their deactivation.[supplied by OMIM]

Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.

Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene.

Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene. Together with GNAQ, it functions as a Gq alpha subunit.

Regulator of G-protein signaling 13 (RGS13) is a protein that in humans is encoded by the RGS13 gene.

Regulator of G-protein signaling 17 is a protein that in humans is encoded by the RGS17 gene.

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000150681 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026357 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Park IK, Klug CA, Li K, Jerabek L, Li L, Nanamori M, et al. (January 2001). "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells". The Journal of Biological Chemistry. 276 (2): 915–923. doi: 10.1074/jbc.M005947200 . PMID 11042171.
1 2 "Entrez Gene: RGS18 regulator of G-protein signalling 18".
1 2 Keramati AR, Chen MH, Rodriguez BA, Yanek LR, Bhan A, Gaynor BJ, et al. (NHLBI Trans-Omics for Precision (TOPMed) Consortium) (June 2021). "Genome sequencing unveils a regulatory landscape of platelet reactivity". Nature Communications. 12 (1): 3626. Bibcode:2021NatCo..12.3626K. doi:10.1038/s41467-021-23470-9. PMC 8206369 . PMID 34131117.
↑ Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, et al. (October 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal. 359 (Pt 1): 109–118. doi:10.1042/bj3590109. PMC 1222126 . PMID 11563974.
↑ Gagnon AW, Murray DL, Leadley RJ (July 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling. 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952.

Nagata Y, Oda M, Nakata H, Shozaki Y, Kozasa T, Todokoro K (May 2001). "A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes". Blood. 97 (10): 3051–3060. doi: 10.1182/blood.V97.10.3051 . PMID 11342430.
Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, et al. (October 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal. 359 (Pt 1): 109–118. doi:10.1042/bj3590109. PMC 1222126 . PMID 11563974.
Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, et al. (February 2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–185. doi:10.1006/geno.2002.6693. PMID 11829488. S2CID 16065132.
Gagnon AW, Murray DL, Leadley RJ (July 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling. 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–569. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Larminie C, Murdock P, Walhin JP, Duckworth M, Blumer KJ, Scheideler MA, Garnier M (March 2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Research. Molecular Brain Research. 122 (1): 24–34. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000150681 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026357 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11042171-5] Park IK, Klug CA, Li K, Jerabek L, Li L, Nanamori M, et al. (January 2001). "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells". The Journal of Biological Chemistry. 276 (2): 915–923. doi: 10.1074/jbc.M005947200 . PMID 11042171.

[entrez-6] 1 2 "Entrez Gene: RGS18 regulator of G-protein signalling 18".

[Keramati_2021-7] 1 2 Keramati AR, Chen MH, Rodriguez BA, Yanek LR, Bhan A, Gaynor BJ, et al. (NHLBI Trans-Omics for Precision (TOPMed) Consortium) (June 2021). "Genome sequencing unveils a regulatory landscape of platelet reactivity". Nature Communications. 12 (1): 3626. Bibcode:2021NatCo..12.3626K. doi:10.1038/s41467-021-23470-9. PMC 8206369 . PMID 34131117.

[pmid11563974-8] Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, et al. (October 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal. 359 (Pt 1): 109–118. doi:10.1042/bj3590109. PMC 1222126 . PMID 11563974.

[pmid11955952-9] Gagnon AW, Murray DL, Leadley RJ (July 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling. 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952.

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