RGS20

RGS20
Identifiers
Aliases	RGS20 , RGSZ1, ZGAP1, g(z)GAP, gz-GAP, regulator of G-protein signaling 20, regulator of G protein signaling 20
External IDs	OMIM: 607193 MGI: 1929866 HomoloGene: 2745 GeneCards: RGS20
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q11.23 Start 53,851,795 bp [1] End 53,959,303 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 A1 Start 4,979,799 bp [2] End 5,140,508 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caudate nucleus nucleus accumbens putamen amygdala ganglionic eminence cingulate gyrus Brodmann area 9 external globus pallidus hippocampus proper prefrontal cortex Top expressed in supraoptic nucleus substantia nigra olfactory tubercle nucleus accumbens globus pallidus piriform cortex primary motor cortex superior frontal gyrus cingulate gyrus Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity GTPase activity Cellular component trans-Golgi network nucleus cytoplasm membrane plasma membrane cytoplasmic vesicle Biological process negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of GTPase activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8601 58175 Ensembl ENSG00000147509 ENSMUSG00000002459 UniProt O76081 Q9QZB1 RefSeq (mRNA) NM_001286673 NM_001286674 NM_001286675 NM_003702 NM_170587 NM_001177795 NM_001290372 NM_021374 RefSeq (protein) NP_001273602 NP_001273603 NP_001273604 NP_003693 NP_733466 NP_001171266 NP_001277301 NP_067349 Location (UCSC) Chr 8: 53.85 – 53.96 Mb Chr 1: 4.98 – 5.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene. ^{[5] [6] [7]}

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM] ^[7]

In melanocytic cells RGS20 gene expression may be regulated by MITF. ^[8]

Interactions

RGS20 has been shown to interact with GNAO1 ^[9] and GNAZ. ^{[5] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000147509 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002459 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Glick JL, Meigs TE, Miron A, Casey PJ (October 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha". The Journal of Biological Chemistry. 273 (40): 26008–13. doi: 10.1074/jbc.273.40.26008 . PMID   9748279.
6. Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM (October 1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily". The Journal of Biological Chemistry. 273 (40): 26014–25. doi: 10.1074/jbc.273.40.26014 . PMID   9748280.
7. "Entrez Gene: RGS20 regulator of G-protein signalling 20".
8. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID   19067971. S2CID   24698373.
9. Pagano M, Jordan JD, Neves SR, Nguyen T, Iyengar R (June 2008). "Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways". Cellular Signalling. 20 (6): 1190–7. doi:10.1016/j.cellsig.2008.02.008. PMC   3107604 . PMID   18407463.
10. Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M (December 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". Journal of Cell Science. 115 (Pt 23): 4483–93. doi: 10.1242/jcs.00093 . PMID   12414994.

Further reading

• Barker SA, Wang J, Sierra DA, Ross EM (December 2001). "RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20". Genomics. 78 (3): 223–9. doi:10.1006/geno.2001.6659. PMID   11735229.
• Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, et al. (February 2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID   11829488. S2CID   16065132.
• Nixon AB, Grenningloh G, Casey PJ (May 2002). "The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly". The Journal of Biological Chemistry. 277 (20): 18127–33. doi: 10.1074/jbc.M201065200 . PMID   11882662.
• Wang Y, Ho G, Zhang JJ, Nieuwenhuijsen B, Edris W, Chanda PK, Young KH (December 2002). "Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling". The Journal of Biological Chemistry. 277 (50): 48325–32. doi: 10.1074/jbc.M206116200 . PMID   12379657.
• Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M (December 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". Journal of Cell Science. 115 (Pt 23): 4483–93. doi: 10.1242/jcs.00093 . PMID   12414994.
• Fischer T, De Vries L, Meerloo T, Farquhar MG (July 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8270–5. Bibcode:2003PNAS..100.8270F. doi: 10.1073/pnas.1432965100 . PMC   166218 . PMID   12826607.
• Xu GY, Hum WT, Sukits SF, Hsiao CL, Liu Y, Malakian K, et al. (April 2004). "1H, 13C and 15N resonance assignments of human RGSZ1". Journal of Biomolecular NMR. 28 (4): 409–10. doi:10.1023/B:JNMR.0000015374.29659.f9. PMID   14872136. S2CID   45949960.
• Ajit SK, Ramineni S, Edris W, Hunt RA, Hum WT, Hepler JR, Young KH (April 2007). "RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling". Cellular Signalling. 19 (4): 723–30. doi:10.1016/j.cellsig.2006.09.008. PMID   17126529.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.