RGS8

RGS8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IHD, 2ODE, 5DO9
Identifiers
Aliases	RGS8 , regulator of G protein signaling 8
External IDs	OMIM: 607189 MGI: 108408 HomoloGene: 23152 GeneCards: RGS8
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q25.3 Start 182,641,816 bp [1] End 182,684,587 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 G3|1 65.41 cM Start 153,528,771 bp [2] End 153,576,069 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens pons putamen caudate nucleus cerebellar vermis sperm hypothalamus prefrontal cortex external globus pallidus Brodmann area 46 Top expressed in cerebellar vermis medial geniculate nucleus medial dorsal nucleus superior colliculus lateral geniculate nucleus olfactory tubercle inferior colliculus superior frontal gyrus nucleus accumbens globus pallidus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding GTPase activator activity GTPase activity Cellular component cytoplasm extrinsic component of cytoplasmic side of plasma membrane neuronal cell body membrane perikaryon plasma membrane dendrite cell projection membrane nucleus Biological process G protein-coupled acetylcholine receptor signaling pathway regulation of dopamine receptor signaling pathway positive regulation of GTPase activity negative regulation of signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85397 67792 Ensembl ENSG00000135824 ENSMUSG00000042671 UniProt P57771 Q8BXT1 RefSeq (mRNA) NM_001102450 NM_033345 NM_001369564 NM_001387847 NM_001387848 NM_001387849 NM_026380 NM_001347115 NM_001357525 RefSeq (protein) NP_001095920 NP_203131 NP_001356493 NP_001334044 NP_080656 NP_001344454 Location (UCSC) Chr 1: 182.64 – 182.68 Mb Chr 1: 153.53 – 153.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 8 is a protein that in humans is encoded by the RGS8 gene. ^{[5] [6]}

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000135824 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042671 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD (Apr 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID   11318611.
6. "Entrez Gene: RGS8 regulator of G-protein signalling 8".

Further reading

• Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell. 86 (3): 445–452. doi: 10.1016/S0092-8674(00)80117-8 . PMID   8756726. S2CID   12427406.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID   11329013. S2CID   25064683.
• Luo X, Popov S, Bera AK, Wilkie TM, Muallem S (2001). "RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations". Molecular Cell. 7 (3): 651–660. doi: 10.1016/S1097-2765(01)00211-8 . PMID   11463389.
• Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM (2011). "Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner". J Biol Chem. 286 (17): 15116–15125. doi: 10.1074/jbc.M110.216234 . PMC   3083217 . PMID   21357625.
• Popov S, Yu K, Kozasa T, Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10 and GAIP retain GTPase activating protein activity in vitro". Proc Natl Acad Sci USA. 94 (14): 7216–20. Bibcode:1997PNAS...94.7216P. doi: 10.1073/pnas.94.14.7216 . PMC   23796 . PMID   9207071.
• Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity". J Biol Chem. 275 (25): 18962–8. doi: 10.1074/jbc.M001128200 . PMID   10747990.
• Ross EM, Wilkie TM (2000). "GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins". Annual Review of Biochemistry. 69: 795–827. doi:10.1146/annurev.biochem.69.1.795. PMID   10966476.
• Saitoh O, Murata Y, Odagiri M, et al. (2002). "Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 10138–43. Bibcode:2002PNAS...9910138S. doi: 10.1073/pnas.152085999 . PMC   126637 . PMID   12110731.
• Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID   11829488. S2CID   16065132.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Masuho I, Itoh M, Itoh H, Saitoh O (2004). "The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression". J. Neurochem. 88 (1): 161–8. doi: 10.1046/j.1471-4159.2003.02139.x . PMID   14675160.
• Larminie C, Murdock P, Walhin JP, et al. (2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Res. Mol. Brain Res. 122 (1): 24–34. doi:10.1016/j.molbrainres.2003.11.014. PMID   14992813.
• Saitoh O, Yoshihiro K (2005). "Biochemical and Electrophysiological Analyses of RGS8 Function". Regulators of G-Protein Signaling, Part B. Methods in Enzymology. Vol. 390. pp. 129–48. doi:10.1016/S0076-6879(04)90009-2. ISBN   978-0-12-182795-3. PMID   15488175.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Benians A, Nobles M, Tinker A (2005). "Participation of RGS8 in the ternary complex of agonist, receptor and G-protein". Biochem. Soc. Trans. 32 (Pt 6): 1045–7. doi:10.1042/BST0321045. PMID   15506959.
• Benians A, Nobles M, Hosny S, Tinker A (2005). "Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics". J. Biol. Chem. 280 (14): 13383–94. doi: 10.1074/jbc.M410163200 . PMID   15677457.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Villasenor A, Wang ZV, Rivera LB, Ocal O, Asterholm IW, Scherer PE, Brekken RA, Cleaver O, Wilkie TM (2010). "Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes". Disease Models & Mechanisms. 3 (9–10): 567–580. doi:10.1242/dmm.003210. PMC   2931535 . PMID   20616094.
• Wilkie TM, Kinch L (2005). "New roles for Galpha and RGS proteins: communication continues despite pulling sisters apart". Current Biology. 15 (20): R843-54. Bibcode:2005CBio...15.R843W. doi: 10.1016/j.cub.2005.10.008 . PMID   16243026. S2CID   18174795.