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The SOS response is a global response to DNA damage in which the cell cycle is arrested and DNA repair and mutagenesis is induced. The system involves the RecA protein. The RecA protein, stimulated by single-stranded DNA, is involved in the inactivation of the repressor (LexA) of SOS response genes thereby inducing the response. It is an error-prone repair system that contributes significantly to DNA changes observed in a wide range of species.
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References
- ↑ Walker, GC (October 1995). "SOS-regulated proteins in translesion DNA synthesis and mutagenesis". Trends in Biochemical Sciences. 20 (10): 416–20. doi:10.1016/s0968-0004(00)89091-x. PMID 8533155.
- ↑ Gillor, Osnat; Vriezen, Jan A. C.; Riley, Margaret A. (Jun 2008). "The role of SOS boxes in enteric bacteriocin regulation". Microbiology. 154 (6): 1783–1792. doi:10.1099/mic.0.2007/016139-0. PMC 2729051 . PMID 18524933.
- ↑ Fernández de Henestrosa AR, Rivera E, Tapias A, Barbé J (June 1998). "Identification of the Rhodobacter sphaeroides SOS box". Mol. Microbiol. 28 (5): 991–1003. doi: 10.1046/j.1365-2958.1998.00860.x . PMID 9663685.
- ↑ Tapias A, Barbé J (August 1999). "Regulation of divergent transcription from the uvrA-ssb promoters in Sinorhizobium meliloti". Mol. Gen. Genet. 262 (1): 121–30. doi:10.1007/s004380051066. PMID 10503543. S2CID 2373618.
- ↑ Erill I, Escribano M, Campoy S, Barbé J (November 2003). "In silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA-regulon". Bioinformatics. 19 (17): 2225–36. doi: 10.1093/bioinformatics/btg303 . PMID 14630651.
- ↑ Campoy S, Fontes M, Padmanabhan S, Cortés P, Llagostera M, Barbé J (August 2003). "LexA-independent DNA damage-mediated induction of gene expression in Myxococcus xanthus". Mol. Microbiol. 49 (3): 769–81. doi:10.1046/j.1365-2958.2003.03592.x. PMID 12864858.
- ↑ Winterling KW, Chafin D, Hayes JJ, et al. (15 April 1998). "The Bacillus subtilis DinR Binding Site: Redefinition of the Consensus Sequence". J. Bacteriol. 180 (8): 2201–11. doi:10.1128/JB.180.8.2201-2211.1998. PMC 107149 . PMID 9555905.
- ↑ Davis EO, Dullaghan EM, Rand L (June 2002). "Definition of the Mycobacterial SOS Box and Use To Identify LexA-Regulated Genes in Mycobacterium tuberculosis". J. Bacteriol. 184 (12): 3287–95. doi:10.1128/JB.184.12.3287-3295.2002. PMC 135081 . PMID 12029045.
- ↑ Mazón G, Lucena JM, Campoy S, Fernández de Henestrosa AR, Candau P, Barbé J (February 2004). "LexA-binding sequences in Gram-positive and cyanobacteria are closely related". Mol. Genet. Genomics. 271 (1): 40–9. doi:10.1007/s00438-003-0952-x. PMID 14652736. S2CID 9219764.
- Erill I, et al. (2004). "Differences in LexA regulon structure among Proteobacteria through in vivo assisted comparative genomics". Nucleic Acids Research. 32 (22): 6617–26. doi:10.1093/nar/gkh996. PMC 545464 . PMID 15604457.
- Shinagawa H (1996). "SOS response as an adaptive response to DNA damage in prokaryotes". Stress-Inducible Cellular Responses. pp. 221–35. doi:10.1007/978-3-0348-9088-5_14. ISBN 978-3-0348-9901-7. PMID 8856977.
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