| Streptomyces hygroscopicus | |
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| Streptomyces hygroscopicus colonies | |
Scientific classification  | |
| Domain: | Bacteria |
| Phylum: | Actinomycetota |
| Class: | Actinomycetia |
| Order: | Streptomycetales |
| Family: | Streptomycetaceae |
| Genus: | Streptomyces |
| Species: | S. hygroscopicus |
| Binomial name | |
| Streptomyces hygroscopicus (Jensen, 1931) Yüntsen et al., 1956 [1] | |
| Subspecies | |
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| Synonyms [2] | |
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Streptomyces hygroscopicus is a bacterial species in the genus Streptomyces . It was first described by Hans Laurits Jensen in 1931. [3]
Cultures of different strains of S. hygroscopicus can be used to produce several chemical compounds or enzymes.
Sirolimus (also known as rapamycin) is an antifungal and immunosuppressant that has been isolated from S. hygroscopicus from soil samples from Easter Island. [4] Ascomycin is another immunosuppressant produced by some strains of S. hygroscopicus; it has a similar structure to sirolimus and can be used to treat autoimmune diseases and skin diseases and can help prevent rejection after an organ transplant.
The antibiotics geldanamycin, hygromycin B, nigericin, validamycin, and cyclothiazomycin are found in S. hygroscopicus.
Indolocarbazoles can be found in S. hygroscopicus .
Milbemycin and milbemycin oxime can be found in S. hygroscopicus cultures.
S. hygroscopicus also produces the natural herbicide bialaphos. [5]
The enzymes alpha,alpha-trehalose-phosphate synthase (GDP-forming), carboxyvinyl-carboxyphosphonate phosphorylmutase, and hygromycin-B kinase can be isolated from cultures of S. hygroscopicus.
Macrolides are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or antifungal activity and are used as pharmaceutical drugs. Rapamycin is also a macrolide and was originally developed as an antifungal, but is now used as an immunosuppressant drug and is being investigated as a potential longevity therapeutic.
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumor (PEComa). It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It is a mechanistic target of rapamycin (mTOR) kinase inhibitor that reduces the sensitivity of T cells and B cells to interleukin-2 (IL-2), inhibiting their activity.
Streptomyces is the largest genus of Actinomycetota, and the type genus of the family Streptomycetaceae. Over 700 species of Streptomyces bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positive, and have very large genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes produce spores, and are noted for their distinct "earthy" odor that results from production of a volatile metabolite, geosmin. Different strains of the same species may colonize very diverse environments.
In organic chemistry, polyketides are a class of natural products derived from a precursor molecule consisting of a chain of alternating ketone and methylene groups: [−C(=O)−CH2−]n. First studied in the early 20th century, discovery, biosynthesis, and application of polyketides has evolved. It is a large and diverse group of secondary metabolites caused by its complex biosynthesis which resembles that of fatty acid synthesis. Because of this diversity, polyketides can have various medicinal, agricultural, and industrial applications. Many polyketides are medicinal or exhibit acute toxicity. Biotechnology has enabled discovery of more naturally-occurring polyketides and evolution of new polyketides with novel or improved bioactivity.
Glufosinate is a naturally occurring broad-spectrum herbicide produced by several species of Streptomyces soil bacteria. Glufosinate is a non-selective, contact herbicide, with some systemic action. Plants may also metabolize bialaphos and phosalacine, other naturally occurring herbicides, directly into glufosinate. The compound irreversibly inhibits glutamine synthetase, an enzyme necessary for the production of glutamine and for ammonia detoxification, giving it antibacterial, antifungal and herbicidal properties. Application of glufosinate to plants leads to reduced glutamine and elevated ammonia levels in tissues, halting photosynthesis and resulting in plant death.
Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. It has been researched for the treatment of autoimmune diseases and skin diseases, and to prevent rejection after an organ transplant.
Hygromycin B is an antibiotic produced by the bacterium Streptomyces hygroscopicus. It is an aminoglycoside that kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis.
The genus Lysobacter belongs to the family Xanthomonadaceae within the Gammaproteobacteria and includes at least 46 named species, including: Lysobacter enzymogenes, L. antibioticus, L. gummosus, L. brunescens, L. defluvii, L. niabensis, L. niastensis, L. daejeonensis, L. yangpyeongensis, L. koreensis, L. concretionis, L. spongiicola, and L. capsici. Lysobacter spp. were originally grouped with myxobacteria because they shared the distinctive trait of gliding motility, but they uniquely display a number of traits that distinguish them from other taxonomically and ecologically related microbes including high genomic G+C content and the lack of flagella. The feature of gliding motility alone has piqued the interest of many, since the role of gliding bacteria in soil ecology is poorly understood. In addition, while a number of different mechanisms have been proposed for gliding motility among a wide range of bacterial species, the genetic mechanism in Lysobacter remains unknown. Members of the Lysobacter group have gained broad interest for production of extracellular enzymes. The group is also regarded as a rich source for production of novel antibiotics, such as β-lactams containing substituted side chains, macrocyclic lactams and macrocyclic peptide or depsipeptide antibiotics like the katanosins.
The milbemycins are a group of macrolides chemically related to the avermectins and were first isolated in 1972 from Streptomyces hygroscopicus. They are used in veterinary medicine as antiparasitic agents against worms, ticks and fleas.
Streptomyces isolates have yielded the majority of human, animal, and agricultural antibiotics, as well as a number of fundamental chemotherapy medicines. Streptomyces is the largest antibiotic-producing genus of Actinomycetota, producing chemotherapy, antibacterial, antifungal, antiparasitic drugs, and immunosuppressants. Streptomyces isolates are typically initiated with the aerial hyphal formation from the mycelium.
Streptomyces antibioticus is a gram-positive bacterium discovered in 1941 by Nobel-prize-winner Selman Waksman and H. Boyd Woodruff. Its name is derived from the Greek "strepto-" meaning "twisted", alluding to this genus' chain-like spore production, and "antibioticus", referring to this species' extensive antibiotic production. Upon its first characterization, it was noted that S. antibioticus produces a distinct soil odor.
Streptomyces lavendulae is a species of bacteria from the genus Streptomyces. It is isolated from soils globally and is known for its production of medically useful biologically active metabolites. To see a photo of this organism click here.
Streptomyces filipinensis is a bacterium species from the genus of Streptomyces which has been isolated from soil on the Philippines. Streptomyces filipinensis produces pentalenolactone I, hygromycin A and filipin.
Streptomyces galbus is a bacterium species from the genus of Streptomyces which has been isolated from soil from West Bengal. Streptomyces galbus produces xylanase, galbonolides A, galbonolides B and the actinomycin X complex.
Streptomyces milbemycinicus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces milbemycinicus produces milbemycin.
Streptomyces mutomycini is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces mutomycini produces mutamycin. Cultures of different strains of S. hygroscopicus can be used to produce a number of chemical compounds or enzymes.
Streptomyces nigrescens is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces nigrescens produces 5-alkyl-1,2,3,4-tetrahydroquinolines and the antibiotics phoslactomycin A - F.
Streptomyces rapamycinicus is a bacterium species from the genus of Streptomyces which has been isolated from soil from the Easter island. Streptomyces rapamycinicus produces sirolimus.
Hygromycin A is a modified cinnamic acid flanked by a furanose sugar and aminocyclitol. It is produced by Streptomyces hygroscopicus, first described in the 1950s.
Streptomyces violaceusniger is a bacterium species from the genus of Streptomyces. Streptomyces violaceusniger has antifungal activity. Streptomyces violaceusniger produces isoafricanol and spirofungin.
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