Tumor protein p53-inducible nuclear protein 1 is a protein that in humans is encoded by the TP53INP1 gene. [5] [6] [7] In mice this protein is also called TRP53INP1 and is encoded by the Trp53inp1 gene. The protein is also referred to as SIP or "stress inducible protein"
TP53INP1 has been shown to interact with HIPK2 [8] and p53. [5] [8]
Tumor protein P53, also known as p53, cellular tumor antigen p53, the Guardian of the Genome, phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog is crucial in multicellular vertebrates, where it prevents cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.
p73 is a protein related to the p53 tumor protein. Because of its structural resemblance to p53, it has also been considered a tumor suppressor. It is involved in cell cycle regulation, and induction of apoptosis. Like p53, p73 is characterized by the presence of different isoforms of the protein. This is explained by splice variants, and an alternative promoter in the DNA sequence.
Tumor protein p63, typically referred to as p63, also known as transformation-related protein 63 is a protein that in humans is encoded by the TP63 gene.
Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene. HIPK2 can be categorized as a Serine/Threonine Protein kinase, specifically one that interacts with homeodomain transcription factors. It belongs to a family of protein kinases known as the DYRK kinases. Within this family HIPK2 belongs to a group of homeodomain-interacting protein kinases (HIPKs), including HIPK1 and HIPK3. HIPK2 can be found in a wide variety of species and its functions in gene expression and apoptosis are regulated by several different mechanisms.
Apoptosis-stimulating of p53 protein 2 (ASPP2) also known as Bcl2-binding protein (Bbp) and tumor suppressor p53-binding protein 2 (p53BP2) is a protein that in humans is encoded by the TP53BP2 gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene.
Nuclear protein 1 is a protein that in humans is encoded by the NUPR1 gene.
Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene.
Inhibitor of growth protein 2 is a protein that in humans is encoded by the ING2 gene.
40S ribosomal protein S10 is a protein that in humans is encoded by the RPS10 gene.
Homeodomain-interacting protein kinase 3 is an enzyme that in humans is encoded by the HIPK3 gene.
40S ribosomal protein S29 is a protein that in humans is encoded by the RPS29 gene.
Ectoderm-neural cortex protein 1 is a protein that in humans is encoded by the ENC1 gene.
Inhibitor of growth protein 3 is a protein that in humans is encoded by the ING3 gene.
Putative quinone oxidoreductase is an enzyme that in humans is encoded by the TP53I3 gene.
Homeodomain-interacting protein kinase 1 is an enzyme that in humans is encoded by the HIPK1 gene.
Tumor protein p53-inducible protein 11 is a protein that in humans is encoded by the TP53I11 gene.
60S ribosomal protein L27a is a protein that in humans is encoded by the RPL27A gene.
Transmembrane protein 49 is a protein that in humans is encoded by the TMEM49 gene.
Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.
 | This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it. |
