TRIP4

TRIP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E5O
Identifiers
Aliases	TRIP4 , ASC-1, ASC1, HsT17391, ZC2HC5, SMABF1, thyroid hormone receptor interactor 4, MDCDC
External IDs	OMIM: 604501 MGI: 1928469 HomoloGene: 9426 GeneCards: TRIP4
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,455,303 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,816,076 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; amniotic fluid; ; jejunal mucosa; ; monocyte; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; ganglionic eminence; ; anterior pituitary; ; rectum; ; glomerulus;
	Top expressed in
	pineal gland; ; spermatocyte; ; left lobe of liver; ; spermatid; ; secondary oocyte; ; substantia nigra; ; cumulus cell; ; calvaria; ; trigeminal ganglion; ; fossa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protease binding ; transcription coactivator activity ; zinc ion binding ; estrogen receptor binding ; protein binding ; histone acetyltransferase binding ; nuclear receptor binding ; ubiquitin-like protein ligase binding ; metal ion binding ; protein kinase binding ;
Cellular component	cytoplasm ; cytosol ; cytoskeleton ; nucleus ; nucleoplasm ; microtubule organizing center ; neuromuscular junction ; nuclear body ; activating signal cointegrator 1 complex ; centrosome ; protein-containing complex ;
Biological process	positive regulation of transcription, DNA-templated ; toxin transport ; intracellular estrogen receptor signaling pathway ; transcription, DNA-templated ; regulation of transcription, DNA-templated ; regulation of myoblast differentiation ;
	Sources:Amigo / QuickGO
Orthologs
	9325
	56404
	ENSG00000103671
	ENSMUSG00000032386
	Q15650
	Q9QXN3
	NM_016213 ; NM_001321924
	NM_001170907 ; NM_019797 ; NM_001357872
	NP_001308853 ; NP_057297
	NP_001164378 ; NP_062771 ; NP_001344801
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 30, 2023

Activating signal cointegrator 1 is a protein that in humans is encoded by the TRIP4 gene.^[5]^[6]

Interactions

TRIP4 has been shown to interact with Nuclear receptor coactivator 1.^[7]

Related Research Articles

The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression.

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 is a nuclear receptor that in humans is encoded by the RXRA gene.

Retinoic acid receptor alpha (RAR-α), also known as NR1B1 is a nuclear receptor that in humans is encoded by the RARA gene.

NF-kappa-B inhibitor beta is a protein that in humans is encoded by the NFKBIB gene.

Serum response factor, also known as SRF, is a transcription factor protein.

Thyroid hormone receptor alpha (TR-alpha) also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear receptor protein that in humans is encoded by the THRA gene.

Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene.

Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene. MED1 functions as a nuclear receptor coactivator.

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.

Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.

Mediator of RNA polymerase II transcription subunit 14 is an enzyme that in humans is encoded by the MED14 gene.

Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.

Thyroid hormone receptor-associated protein 3 is a protein that in humans is encoded by the THRAP3 gene.

Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.

Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.

Activating signal cointegrator 1 complex subunit 2 is a protein that in humans is encoded by the ASCC2 gene.

Nuclear receptor coregulators are a class of transcription coregulators that have been shown to be involved in any aspect of signaling by any member of the nuclear receptor superfamily. A comprehensive database of coregulators for nuclear receptors and other transcription factors was previously maintained at the Nuclear Receptor Signaling Atlas website which has since been replaced by the Signaling Pathways Project website.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000103671 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032386 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi: 10.1210/mend.9.2.7776974 . PMID 7776974.
↑ "Entrez Gene: TRIP4 thyroid hormone receptor interactor 4".
↑ Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603 . PMID 10454579.

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Jung DJ, Sung HS, Goo YW, et al. (2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Mol. Cell. Biol. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772 . PMID 12077347.
Lee SK, Anzick SL, Choi JE, et al. (1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi: 10.1074/jbc.274.48.34283 . PMID 10567404.
Kim HJ, Yi JY, Sung HS, et al. (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603 . PMID 10454579.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000103671 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032386 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7776974-5] Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi: 10.1210/mend.9.2.7776974 . PMID 7776974.

[entrez-6] "Entrez Gene: TRIP4 thyroid hormone receptor interactor 4".

[pmid10454579-7] Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603 . PMID 10454579.

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TRIP4

Contents

Interactions

Related Research Articles

References

Further reading