The 1888 Liverpool West Derby by-election was held on 10 August 1888 after the resignation of the incumbent Conservative Party MP Claud Hamilton. It was retained by the unopposed Conservative Candidate William Cross.
| Party | Candidate | Votes | % | ±% | |
|---|---|---|---|---|---|
| Conservative | William Cross | Unopposed | N/A | N/A | |
| Conservative hold | |||||