Potito Starace and Martín Vassallo Argüello were the defending champions. They were both present but did not compete together.
Starace partnered with Nicolás Massú, but lost in the semifinals to Oliver Marach and Michal Mertiňák.
Vassallo Argüello partnered with Albert Montañés, but lost in the first round to Óscar Hernández and Sergio Roitman.
Agustín Calleri and Luis Horna were the defending champions of the 2008 Copa Telmex men's doubles tennis tournament, but did not play together that year.
Horacio Zeballos Jr. is an Argentine professional tennis player. His career-high singles ranking is world No. 39, and his career-high doubles ranking is world No. 3. In doubles, he has reached the men's doubles finals at the 2019 US Open and Wimbledon 2021 alongside Marcel Granollers. In singles, he has reached the fourth round at the French Open, doing so in 2017.
Máximo González and Juan Mónaco were the defending champions, but González chose not to participate this year.
Mónaco partnered with Pablo Cuevas, but they lost in the second round against Victor Hănescu and Horia Tecău.
František Čermák and Michal Mertiňák won in the final 6–4, 6–3, against Marcel Granollers and Tommy Robredo.
Tommy Robredo and Marcel Granollers were the defending champions. Robredo chose to compete in the 2010 ABN AMRO World Tennis Tournament instead.
Granollers partnered with Pablo Cuevas, and they won in the final 7–5, 6–4 against Łukasz Kubot and Oliver Marach.
Pablo Cuevas and Marcel Granollers were the defending champions, but Granollers chose to compete in Rotterdam.
Cuevas played with Eduardo Schwank, but lost to Fabio Fognini and David Marrero in the quarterfinals.
Marcelo Melo and Bruno Soares won the title, defeating Pablo Andújar and Daniel Gimeno-Traver 7–6(4), 6–3 in the final.
Sebastián Prieto and Horacio Zeballos were the defending champions, but decided not to participate.
Oliver Marach and Leonardo Mayer defeated Franco Ferreiro and André Sá 7–6(6), 6–3 in the final.
Oliver Marach and Santiago Ventura were the defending champions, but decided not to participate. Marach competed in the Serbia Open instead.
Simone Bolelli of Italy and Horacio Zeballos of Argentina defeated in the final the German couple Andreas Beck and Christopher Kas 7–6(3), 6–4 to win the title.
Paolo Lorenzi and Potito Starace were the defending champions, but decided not to participate together. Lorenzi played alongside Filippo Volandri, but lost in the quarterfinals to Oliver Marach and Florin Mergea. Starace teamed up with Daniele Bracciali, but lost in the quarterfinals to Marcel Granollers and Marc López.
Marach and Mergea won the title, defeating Juan Sebastián Cabal and Robert Farah in the final, 6–3, 6–4.
Simone Bolelli and Fabio Fognini were the defending champions, but they decided not to participate.
Marcel Granollers and Marc López won the title, defeating Pablo Cuevas and Horacio Zeballos in the final, 7–5, 6–4.
Bob and Mike Bryan were the defending champions, but lost in the quarterfinals to Marcel Granollers and Marc López.
Ryan Harrison and Michael Venus won the men's doubles tennis title at the 2017 French Open, defeating Santiago González and Donald Young in the final, 7–6(7–5), 6–7(4–7), 6–3. In a rare coincidence, none of the four players had ever previously appeared in the men's doubles finals of a Grand Slam tournament prior to the event.
Pierre-Hugues Herbert and Nicolas Mahut were the defending champions, but lost in the second round to Jay Clarke and Marcus Willis.
Jamie Murray and Bruno Soares were the defending champions, but lost in the quarterfinals to Jean-Julien Rojer and Horia Tecău.
Rohan Bopanna and Pablo Cuevas were the defending champions, but chose not to participate together. Bopanna played alongside Édouard Roger-Vasselin, but lost in the semifinals to Oliver Marach and Mate Pavić. Cuevas teamed up with Marcel Granollers, but lost in the quarterfinals to Bob and Mike Bryan.
Pierre-Hugues Herbert and Nicolas Mahut won the men's doubles tennis title at the 2018 French Open, defeating Oliver Marach and Mate Pavić in the final, 6–2, 7–6(7–4). Herbert and Mahut were the third all-French team to reach the French Open men's doubles final in six years.
Juan Sebastián Cabal and Robert Farah won their second consecutive Grand Slam men's doubles title, defeating Marcel Granollers and Horacio Zeballos in the final, 6–4, 7–5 to win the men's doubles tennis title at the 2019 US Open. Cabal and Farah retained the ATP no. 1 doubles ranking. Mike Bryan, Łukasz Kubot and Nicolas Mahut were also in contention for the top ranking at the start of the tournament.
Ivan Dodig and Filip Polášek were the defending champions but lost in the first round to Pablo Carreño Busta and Alex de Minaur.
Juan Sebastián Cabal and Robert Farah were the two-time defending champions, but lost in the second round to Rohan Bopanna and Denis Shapovalov.
Oliver Marach and Jürgen Melzer were the defending champions, but Melzer chose not to participate this year. Marach played alongside Raven Klaasen, but lost in the first round to Kevin Krawietz and Andreas Mies.
Łukasz Kubot 
Oliver Marach 
Potito Starace 
Horacio Zeballos 
