| Men's singles | |
|---|---|
| 2016 Claro Open Medellín | |
| Champion |  Facundo Bagnis |
| Runner-up |  Caio Zampieri |
| Final score | 6–7(3–7), 7–5, 6–2 |
Paolo Lorenzi was the defending champion but chose not to defend his title.
Facundo Bagnis won the title after defeating Caio Zampieri 6–7(3–7), 7–5, 6–2 in the final.
Víctor Estrella Burgos (first round) Facundo Bagnis (champion) Rogério Dutra Silva (semifinals) Renzo Olivo (second round) João Souza (semifinals)
Santiago Giraldo (quarterfinals) Nicolás Kicker (second round) Alejandro González (second round)| Semifinals | Final | ||||||||||||
| Caio Zampieri | 3 | 710 | 6 | ||||||||||
| 3 | Rogério Dutra Silva | 6 | 68 | 2 | |||||||||
| Caio Zampieri | 77 | 5 | 2 | ||||||||||
| 2 | Facundo Bagnis | 63 | 7 | 6 | |||||||||
| 5 | João Souza | 7 | 2 | 2 | |||||||||
| 2 | Facundo Bagnis | 5 | 6 | 6 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | V Estrella Burgos | 65 | 67 | ||||||||||||||||||||||||
| A Falla | 77 | 79 | A Falla | 6 | 77 | ||||||||||||||||||||||
| A Ghem | 6 | 6 | A Ghem | 3 | 63 | ||||||||||||||||||||||
 Bastián Malla | 2 | 3 | A Falla | 63 | 77 | 2 | |||||||||||||||||||||
| C Zampieri | 6 | 6 | C Zampieri | 77 | 62 | 6 | |||||||||||||||||||||
 C Lindell | 3 | 3 | C Zampieri | 7 | 6 | ||||||||||||||||||||||
| Alt | N Barrientos | 2 | 2 | 8 | A González | 5 | 4 | ||||||||||||||||||||
| 8 | A González | 6 | 6 | C Zampieri | 3 | 710 | 6 | ||||||||||||||||||||
| 3 | R Dutra Silva | 6 | 6 | 3 | R Dutra Silva | 6 | 68 | 2 | |||||||||||||||||||
| LL | B Sant'Anna | 4 | 1 | 3 | R Dutra Silva | 77 | 4 | 6 | |||||||||||||||||||
| JI Londero | 6 | 69 | 5 | F Mena | 64 | 6 | 2 | ||||||||||||||||||||
| F Mena | 3 | 711 | 7 | 3 | R Dutra Silva | 68 | 6 | 6 | |||||||||||||||||||
| E Struvay | 6 | 6 | E Struvay | 710 | 3 | 2 | |||||||||||||||||||||
| Alt | José Pereira | 3 | 4 | E Struvay | 6 | 77 | |||||||||||||||||||||
| Q | F Romboli | 6 | 65 | 66 | 7 | N Kicker | 4 | 65 | |||||||||||||||||||
| 7 | N Kicker | 3 | 77 | 78 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | J Souza | 65 | 6 | 6 | |||||||||||||||||||||||
| WC | Gregorio Cordonnier | 77 | 3 | 2 | 5 | J Souza | 6 | 6 | |||||||||||||||||||
| WC | DE Galán | 4 | 3 |  A El Mihdawy | 2 | 3 | |||||||||||||||||||||
| A El Mihdawy | 6 | 6 | 5 | J Souza | 6 | 7 | |||||||||||||||||||||
| G Lama | 0r | J Hernández | 0 | 5 | |||||||||||||||||||||||
| J Hernández | 0 | J Hernández | 6 | 4 | 6 | ||||||||||||||||||||||
| Q | O Luz | 4 | 6 | 3 | 4 | R Olivo | 3 | 6 | 4 | ||||||||||||||||||
| 4 | R Olivo | 6 | 4 | 6 | 5 | J Souza | 7 | 2 | 2 | ||||||||||||||||||
| 6 | S Giraldo | 6 | 6 | 2 | F Bagnis | 5 | 6 | 6 | |||||||||||||||||||
| WC | Felipe Mantilla | 1 | 2 | 6 | S Giraldo | 6 | 6 | ||||||||||||||||||||
| Q | N Santos | 4 | 6 | 6 | Q | N Santos | 3 | 3 | |||||||||||||||||||
| WC | Sergio Luis Hernández Ramírez | 6 | 2 | 1 | 6 | S Giraldo | 3 | 6 | 4 | ||||||||||||||||||
| Q | M Zormann | 6 | 2 | 6 | 2 | F Bagnis | 6 | 2 | 6 | ||||||||||||||||||
| A Collarini | 3 | 6 | 4 | Q | M Zormann | 3 | 4 | ||||||||||||||||||||
 G Escobar | 6 | 3 | 2 | 2 | F Bagnis | 6 | 6 | ||||||||||||||||||||
| 2 | F Bagnis | 3 | 6 | 6 | |||||||||||||||||||||||
Thomaz Bellucci was the defending champion, but lost to Fabio Fognini in the quarterfinals.
Tommy Robredo won the title, defeating Santiago Giraldo 6–2, 2–6, 7–6(7–5), in the final.
Robin Haase was the two-time defending champion, but lost in the semifinals to Marcel Granollers. Granollers went on to win the title, defeating Juan Mónaco in the final, 0-6, 7–6(7–3), 6–4.
Guido Andreozzi was the defending champion, but lost to compatriot Martín Alund in the quarterfinals.
Top seed Horacio Zeballos won the title defeating Facundo Bagnis 6–7(4–7), 6–3, 6–3.
Federico Delbonis was the defending champion, but lost to Facundo Bagnis in the first round.
Pablo Cuevas won the title, defeating Luca Vanni in the final, 6–4, 3–6, 7–6(7–4).
Rafael Nadal was the defending champion, but lost in the semifinals to Fabio Fognini.
Fernando Verdasco was the defending champion, but lost to Sam Querrey in the semifinals.
Jack Sock won his first ATP singles title, defeating Querrey in the final, 7–6(11–9), 7–6(7–2).
Pablo Cuevas was the defending champion, but he chose to defend his title in Båstad instead.
Pablo Andújar was the defending champion, but lost to Thomaz Bellucci in the quarterfinals.
Rafael Nadal was the defending champion, but lost to Dominic Thiem in the semifinals.
David Ferrer was the defending champion, but lost in the quarterfinals to Dominic Thiem.
Facundo Argüello was the defending champion but chose not to defend his title.
Eduardo Struvay was the defending champion but lost in the second round to Facundo Bagnis.
Máximo González was the defending champion but lost in the first round to Facundo Bagnis.
Federico Delbonis was the defending champion but chose not to defend his title.
Tommy Robredo was the defending champion but retired in the first round against Maxime Janvier.
Pablo Andújar was the defending champion but chose not to defend his title.
Cristian Garín was the defending champion but chose not to defend his title.
Cristian Garín defeated Facundo Bagnis in the final, 6–4, 6–7(3–7), 7–5 to capture the men's singles tennis title at the 2021 Chile Open.
Matteo Berrettini defeated Aslan Karatsev in the final, 6–1, 3–6, 7–6(7–0), to win the men's singles tennis title at the 2021 Serbia Open.
Pedro Martínez defeated Sebastián Báez in the final, 4–6, 6–4, 6–4 to win the singles title at the 2022 Chile Open. It was his first ATP Tour title.