| Singles | |
|---|---|
| 2016 Uruguay Open | |
| Champion |  Diego Schwartzman |
| Runner-up |  Rogério Dutra Silva |
| Score | 6–4, 6–1 |
Guido Pella was the defending champion but chose not to defend his title.
Diego Schwartzman won the title after defeating Rogério Dutra Silva 6–4, 6–1 in the final.
Nicolás Almagro (quarterfinals) Diego Schwartzman (champion) Horacio Zeballos (quarterfinals) Íñigo Cervantes (quarterfinals) Carlos Berlocq (semifinals, retired) Rogério Dutra Silva (final) Guido Andreozzi (second round, retired) Nicolás Kicker (quarterfinals)| Semifinals | Final | ||||||||||||
 Cristian Garín | 2 | 2 | |||||||||||
| 6 | Rogério Dutra Silva | 6 | 6 | ||||||||||
| 6 | Rogério Dutra Silva | 4 | 1 | ||||||||||
| 2/WC | Diego Schwartzman | 6 | 6 | ||||||||||
| 5 | Carlos Berlocq | 1 | 1r | ||||||||||
| 2/WC | Diego Schwartzman | 6 | 4 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1/WC | N Almagro | 77 | 78 | ||||||||||||||||||||||||
| Q | N Jarry | 64 | 66 | 1/WC | N Almagro | 7 | 6 | ||||||||||||||||||||
 A De Greef | 77 | 6 | A De Greef | 5 | 3 | ||||||||||||||||||||||
| Q | A Molteni | 62 | 3 | 1/WC | N Almagro | 6 | 5 | 3 | |||||||||||||||||||
| H Podlipnik | 3 | 6 | 3 | C Garín | 3 | 7 | 6 | ||||||||||||||||||||
| C Garín | 6 | 3 | 6 | C Garín | 6 | 3 | |||||||||||||||||||||
| WC |  M Felder | 0 | 2 | 7 | G Andreozzi | 4 | 2r | ||||||||||||||||||||
| 7 | G Andreozzi | 6 | 6 | C Garín | 2 | 2 | |||||||||||||||||||||
| 3 | H Zeballos | 6 | 6 | 6 | R Dutra Silva | 6 | 6 | ||||||||||||||||||||
 E Gómez | 4 | 4 | 3 | H Zeballos | 6 | 3 | 6 | ||||||||||||||||||||
| JI Londero | 6 | 6 | JI Londero | 2 | 6 | 3 | |||||||||||||||||||||
| MT Barrios Vera | 0 | 1 | 3 | H Zeballos | 6 | 4 | 2 | ||||||||||||||||||||
 DE Galán | 5 | 7 | 5 | 6 | R Dutra Silva | 2 | 6 | 6 | |||||||||||||||||||
| F Mena | 7 | 5 | 7 | F Mena | 1 | 2 | |||||||||||||||||||||
| Q |  M Linzer | 77 | 2 | 0r | 6 | R Dutra Silva | 6 | 6 | |||||||||||||||||||
| 6 | R Dutra Silva | 65 | 6 | 2 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | C Berlocq | 6 | 6 | ||||||||||||||||||||||||
| Juan Ignacio Galarza | 2 | 2 | 5 | C Berlocq | 6 | 6 | |||||||||||||||||||||
| F Coria | 6 | 6 | F Coria | 1 | 2 | ||||||||||||||||||||||
| A Collarini | 4 | 1 | 5 | C Berlocq | 3 | 6 | 6 | ||||||||||||||||||||
| C Zampieri | 3 | 77 | 6 | 4 | Í Cervantes | 6 | 4 | 3 | |||||||||||||||||||
| Mariano Kestelboim | 6 | 65 | 1 | C Zampieri | 7 | 2 | 1 | ||||||||||||||||||||
| A Velotti | 3 | 4 | 4 | Í Cervantes | 5 | 6 | 6 | ||||||||||||||||||||
| 4 | Í Cervantes | 6 | 6 | 5 | C Berlocq | 1 | 1r | ||||||||||||||||||||
| 8 | N Kicker | 6 | 6 | 2/WC | D Schwartzman | 6 | 4 | ||||||||||||||||||||
 K Uchida | 2 | 1 | 8 | N Kicker | 6 | 6 | |||||||||||||||||||||
| Bastián Malla | 6 | 6 | B Malla | 1 | 1 | ||||||||||||||||||||||
| WC | S Maresca | 3 | 4 | 8 | N Kicker | 4 | 64 | ||||||||||||||||||||
| Q | J Menezes | 2 | 3 | 2/WC | D Schwartzman | 6 | 77 | ||||||||||||||||||||
| T Lipovšek Puches | 6 | 6 | T Lipovšek Puches | 1 | 3 | ||||||||||||||||||||||
| Maximiliano Estévez | 0 | 1 | 2/WC | D Schwartzman | 6 | 6 | |||||||||||||||||||||
| 2/WC | D Schwartzman | 6 | 6 | ||||||||||||||||||||||||
Carlos Berlocq was the defending champion but decided not to participate.
Diego Schwartzman defeated Guillaume Rufin 6–1, 7–5 in the final to win the title.
Paul Capdeville was the defending champion, but lost in the second round to Marco Trungelliti.
Facundo Bagnis won the title by defeating Thiemo de Bakker 7–6(7–2), 7–6(7–3) in the final.
Horacio Zeballos was the defending champion but decided not to participate.
Thomaz Bellucci won the title over Diego Sebastián Schwartzman
Rafael Nadal was the defending champion but chose not to compete.
Last year's champion Rogério Dutra da Silva was not defending his title.
Last year's champion Paul Capdeville was not defending his title.
Diego Schwartzman was the defending champion, but lost in the final to Facundo Argüello, 7–5, 6–3.
Kyle Edmund won the title, defeating Carlos Berlocq in the final 6–0, 6–4.
This was the first edition of the tournament, Rogério Dutra Silva won the title defeating Horacio Zeballos in the final 7–5, 3–6, 7–5.
Pablo Carreño Busta was the defending champion but chose not to participate.
Borna Ćorić was the defending champion but chose not to participate.
Blaž Rola was the defending champion but chose not to defend his title.
Facundo Argüello was the defending champion but chose not to defend his title.
Dominic Thiem was the defending champion, but chose to compete in Rotterdam instead.
Diego Schwartzman was the defending champion but chose not to defend his title.
Alexandr Dolgopolov was the defending champion, but withdrew before the tournament began.
Two-time defending champion Rafael Nadal defeated Stefanos Tsitsipas in the final, 6–2, 6–1 to win the singles tennis title at the 2018 Barcelona Open. With the win, Nadal retained the ATP no. 1 singles ranking. It was Nadal's record-extending eleventh Barcelona Open title and his 20th ATP 500 title overall, equaling Roger Federer's record. It was Tsitsipas' maiden ATP Tour final.
Dominic Thiem was the defending champion, but lost to Diego Schwartzman in the semifinals.
Diego Schwartzman was the defending champion, but he retired in the first round against Pablo Cuevas.
David Marrero and Fernando Verdasco were the defending champions, but Verdasco chose not to defend the title and Marrero chose to compete in Marseille instead.