| Singles | |
|---|---|
| 2021 São Paulo Challenger de Tênis | |
| Champion |  Juan Pablo Ficovich |
| Runner-up |  Luciano Darderi |
| Score | 6–3, 7–5 |
Felipe Meligeni Alves was the defending champion [1] but withdrew before his semifinal match with Luciano Darderi.
Juan Pablo Ficovich won the title after defeating Darderi 6–3, 7–5 in the final.
Pablo Cuevas (withdrew)
Hugo Dellien (quarterfinals)
Thiago Seyboth Wild (second round) Juan Ignacio Londero (first round)
Nicolás Jarry (semifinals) Felipe Meligeni Alves (semifinals, withdrew) Nicolás Kicker (first round) Pedro Cachin (second round)| Semifinals | Final | ||||||||||||
| 6 | Felipe Meligeni Alves | ||||||||||||
| Q | Luciano Darderi | w/o | |||||||||||
| Q | Luciano Darderi | 3 | 5 | ||||||||||
| Juan Pablo Ficovich | 6 | 7 | |||||||||||
| Juan Pablo Ficovich | 6 | 77 | |||||||||||
| 5 | Nicolás Jarry | 2 | 65 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| A Collarini | 6 | 77 | |||||||||||||||||||||||||
| GA Olivieri | 2 | 65 | A Collarini | 4 | |||||||||||||||||||||||
| WC | Oscar José Gutierrez | 7 | 65 | 0 | H Casanova | 1r | |||||||||||||||||||||
| H Casanova | 5 | 77 | 6 | A Collarini | 4 | 6 | 3 | ||||||||||||||||||||
 J Nikles | 64 | 77 | 6 | 6 | F Meligeni Alves | 6 | 4 | 6 | |||||||||||||||||||
 K Uchida | 77 | 63 | 0 | J Nikles | 77 | 2 | 1 | ||||||||||||||||||||
 P Krstin | 4 | 0r | 6 | F Meligeni Alves | 65 | 6 | 6 | ||||||||||||||||||||
| 6 | F Meligeni Alves | 6 | 0 | 6 | F Meligeni Alves | ||||||||||||||||||||||
| 3 | T Seyboth Wild | 6 | 6 | Q | L Darderi | w/o | |||||||||||||||||||||
| Alt |  A González | 3 | 4 | 3 | T Seyboth Wild | 3 | 5 | ||||||||||||||||||||
| F Díaz Acosta | 7 | 6 | F Díaz Acosta | 6 | 7 | ||||||||||||||||||||||
| Q | G Villanueva | 5 | 1 | F Díaz Acosta | 3 | 4 | |||||||||||||||||||||
| WC | M Alves | 1 | 1 | Q | L Darderi | 6 | 6 | ||||||||||||||||||||
| Q | L Darderi | 6 | 6 | Q | L Darderi | 6 | 6 | ||||||||||||||||||||
 N Álvarez Varona | 7 | 6 | N Álvarez Varona | 4 | 1 | ||||||||||||||||||||||
| 7 | N Kicker | 5 | 3 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | P Cachin | 6 | 6 | ||||||||||||||||||||||||
| Alt | Facundo Juárez | 3 | 2 | 8 | P Cachin | 5 | 2 | ||||||||||||||||||||
| JP Ficovich | 5 | 6 | 6 | JP Ficovich | 7 | 6 | |||||||||||||||||||||
 R Cid Subervi | 7 | 4 | 0 | JP Ficovich | 6 | 6 | |||||||||||||||||||||
| Q | Matías Zukas | 1 | 1 | WC | G Heide | 3 | 0 | ||||||||||||||||||||
| Q | I Marcondes | 6 | 6 | Q | I Marcondes | 6 | 4 | 3 | |||||||||||||||||||
| WC | G Heide | 6 | 7 | WC | G Heide | 4 | 6 | 6 | |||||||||||||||||||
| 4 | JI Londero | 3 | 5 | JP Ficovich | 6 | 77 | |||||||||||||||||||||
| 5 | N Jarry | 77 | 6 | 5 | N Jarry | 2 | 65 | ||||||||||||||||||||
| LL | A Gómez | 61 | 4 | 5 | N Jarry | 6 | 6 | ||||||||||||||||||||
| P Sakamoto | 2 | 7 | 7 | P Sakamoto | 3 | 4 | |||||||||||||||||||||
| Alt | Gilbert Klier Júnior | 6 | 5 | 5 | 5 | N Jarry | 77 | 77 | |||||||||||||||||||
| O Luz | 3 | 64 | 2 | H Dellien | 63 | 65 | |||||||||||||||||||||
| Alt | D Dutra da Silva | 6 | 77 | Alt | D Dutra da Silva | 6 | 1 | 3 | |||||||||||||||||||
| M Pucinelli de Almeida | 3 | 5 | 2 | H Dellien | 4 | 6 | 6 | ||||||||||||||||||||
| 2 | H Dellien | 6 | 7 | ||||||||||||||||||||||||
Juan Carlos Aguilar and Felipe Meligeni Alves were the defending champions, but both players were ineligible to participate.
Sebastián Báez was the defending champion but lost in the final to Juan Pablo Varillas.
Juan Pablo Varillas was the defending champion but lost in the quarterfinals to Marcelo Tomás Barrios Vera.
Guido Andreozzi and Andrés Molteni were the defending champions but only Andreozzi chose to defend his title, partnering Thiago Seyboth Wild. Andreozzi withdrew from the tournament before his quarterfinal match.
Facundo Bagnis and Andrés Molteni were the defending champions but chose not to defend their title.
Luis David Martínez and Felipe Meligeni Alves were the defending champions but chose to defend their title with different partners. Martínez partnered Fernando Romboli but lost in the semifinals to Nicolás Barrientos and Alejandro Gómez. Meligeni Alves partnered Rafael Matos but withdrew before the final due to a positive test for COVID-19.
Sebastián Báez was the defending champion but chose not to defend his title.
Santiago Rodríguez Taverna was the defending champion but lost in the quarterfinals to Genaro Alberto Olivieri.
Conner Huertas del Pino and Mats Rosenkranz were the defending champions but only Huertas del Pino chose to defend his title, partnering Alexander Merino. Huertas del Pino lost in the first round to Murkel Dellien and Jorge Panta.
This was the first edition of the tournament. The tournament was originally scheduled to be played in Villa Allende but was relocated to Buenos Aires due to operational issues at the venue in Villa Allende.
Gerald Melzer was the defending champion but lost in the final to Juan Pablo Ficovich.
Orlando Luz and Felipe Meligeni Alves were the defending champions but only Meligeni Alves chose to defend his title, partnering Marcelo Demoliner. Meligeni Alves lost in the quarterfinals to Luciano Darderi and Fernando Romboli.
This was the first edition of the tournament.
Sebastián Báez was the defending champion but chose not to defend his title.
Rafael Matos and Felipe Meligeni Alves were the defending champions but only Meligeni Alves chose to defend his title, partnering Matheus Pucinelli de Almeida. Meligeni Alves withdrew before his first round match due to injury.
This was the first edition of the tournament.
Alejandro Tabilo was the defending champion but chose not to defend his title.
This was the third edition of the tournament as an ATP Challenger Tour event and the first edition since 2012.
This was the first edition of the tournament.
This was the first edition of the tournament.