Guido Andreozzi and Guillermo Durán were the defending champions but only Andreozzi chose to defend his title, partnering Andrés Molteni. Andreozzi successfully defended his title.
Hugo Dellien and Guillermo Durán were the defending champions but only Dellien chose to defend his title, partnering Federico Zeballos. Dellien and Zeballos withdrew before their quarterfinal match.
Guido Andreozzi and Guillermo Durán were the defending champions but chose not to defend their title.
Guillermo Durán and Roberto Quiroz were the defending champions but only Quiroz chose to defend his title, partnering Yannick Hanfmann. Quiroz lost in the first round to Luis David Martínez and Felipe Meligeni Alves.
Guido Andreozzi and Guillermo Durán were the defending champions but chose not to defend their title.
Guido Andreozzi and Guillermo Durán were the defending champions but only Durán chose to defend his title, partnering Mariano Kestelboim. Durán lost in the first round to Facundo Mena and Camilo Ugo Carabelli.
This was the first edition of the tournament. It was originally scheduled to take place in Florianópolis but was relocated to São Paulo and took the São Paulo Challenger de Tênis namesake.
Orlando Luz and Rafael Matos were the defending champions but only Matos chose to defend his title, partnering João Menezes. Matos withdrew from the tournament before his quarterfinal match.
Sadio Doumbia and Fabien Reboul were the defending champions and successfully defended their title, defeating Guido Andreozzi and Guillermo Durán 7–5, 6–3 in the final.
Guido Andreozzi and Andrés Molteni were the defending champions but only Andreozzi chose to defend his title, partnering Thiago Seyboth Wild. Andreozzi withdrew from the tournament before his quarterfinal match.
Santiago González and Andrés Molteni defeated Andrej Martin and Tristan-Samuel Weissborn in the final, 7–5, 6–3, to win the doubles tennis title at the 2022 Córdoba Open. It was their third career ATP Tour doubles title together. As alternates, Martin and Weissborn were competing in their second event as a team.
Diego Hidalgo and Cristian Rodríguez were the defending champions but lost in the semifinals to Jesper de Jong and Bart Stevens.
Santiago Rodríguez Taverna was the defending champion but lost in the quarterfinals to Genaro Alberto Olivieri.
This was the first edition of the tournament and was part of the 2022 Legión Sudamericana.
Julio Peralta and Horacio Zeballos were the defending champions when the event was last held in 2015, but they chose not to defend their title.
Rafael Matos and Felipe Meligeni Alves were the defending champions but only Meligeni Alves chose to defend his title, partnering Matheus Pucinelli de Almeida. Meligeni Alves withdrew before his first round match due to injury.
Alejandro Tabilo was the defending champion but chose not to defend his title.
Rafael Matos and Felipe Meligeni Alves were the defending champions but only Meligeni Alves chose to defend his title, partnering Matheus Pucinelli de Almeida. They withdrew before their first round match.
Arklon and Conner Huertas del Pino were the defending champions but lost in the semifinals to Francisco Comesaña and Thiago Seyboth Wild.
Guido Andreozzi and Guillermo Durán were the defending champions but chose not to defend their title.
Guillermo Durán 
Felipe Meligeni Alves 
Luciano Darderi 
