| Singles | |
|---|---|
| 2022 Grand Est Open 88 | |
| Champion |  Sara Errani |
| Runner-up |  Dalma Gálfi |
| Score | 6–4, 1–6, 7–6(7–4) |
Anhelina Kalinina was the defending champion [1] but chose not to participate.
Sara Errani won the title, defeating Dalma Gálfi in the final, 6–4, 1–6, 7–6(7–4). [2]
Anna Bondár (semifinals)
Varvara Gracheva (first round) Jasmine Paolini (quarterfinals)
Océane Dodin (first round)
Arantxa Rus (second round) Dalma Gálfi (final)
Ylena In-Albon (first round)
Katie Volynets (first round)| Semifinals | Final | ||||||||||||
| 1 | Anna Bondár | 3 | 1 | ||||||||||
| 6 | Dalma Gálfi | 6 | 6 | ||||||||||
| 6 | Dalma Gálfi | 4 | 6 | 64 | |||||||||
| Sara Errani | 6 | 1 | 77 | ||||||||||
 Cristina Bucșa | 3 | 2 | |||||||||||
| Sara Errani | 6 | 6 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | A Bondár | 6 | 6 | ||||||||||||||||||||||||
 L Pigossi | 4 | 2 | 1 | A Bondár | 6 | 6 | |||||||||||||||||||||
| Q |  L Papadakis | 3 | 6 | 6 | Q | L Papadakis | 2 | 2 | |||||||||||||||||||
| PR |  Z Hives | 6 | 3 | 3 | 1 | A Bondár | 4 | 6 | 6 | ||||||||||||||||||
| WC | A Albié | 5 | 3 | O Gadecki | 6 | 3 | 2 | ||||||||||||||||||||
| O Gadecki | 7 | 6 | O Gadecki | 6 | 6 | ||||||||||||||||||||||
| E Jacquemot | 6 | 3 | 6 | E Jacquemot | 2 | 1 | |||||||||||||||||||||
| 8 | K Volynets | 4 | 6 | 2 | 1 | A Bondár | 3 | 1 | |||||||||||||||||||
| 3 | J Paolini | 0 | 6 | 6 | 6 | D Gálfi | 6 | 6 | |||||||||||||||||||
| B Pera | 6 | 2 | 1 | 3 | J Paolini | 6 | 6 | ||||||||||||||||||||
| WC | S Vögele | 1 | 3 | A Blinkova | 0 | 3 | |||||||||||||||||||||
| A Blinkova | 6 | 6 | 3 | J Paolini | 5 | 0 | |||||||||||||||||||||
| WC | M Rouvroy | 4 | 1 | 6 | D Gálfi | 7 | 6 | ||||||||||||||||||||
 A Cadanțu-Ignatik | 6 | 6 | A Cadanțu-Ignatik | 4 | 4 | ||||||||||||||||||||||
| K Mladenovic | 77 | 4 | 3 | 6 | D Gálfi | 6 | 6 | ||||||||||||||||||||
| 6 | D Gálfi | 65 | 6 | 6 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | A Rus | 6 | 6 | ||||||||||||||||||||||||
| WC | J Gervais | 0 | 3 | 5 | A Rus | 5 | 2 | ||||||||||||||||||||
| C Bucșa | 6 | 6 | C Bucșa | 7 | 6 | ||||||||||||||||||||||
 ML Carlé | 2 | 3 | C Bucșa | w/o | |||||||||||||||||||||||
| A Lázaro García | 1 | 6 | 3 | J Ponchet | |||||||||||||||||||||||
| J Ponchet | 6 | 4 | 6 | J Ponchet | 66 | 6 | 6 | ||||||||||||||||||||
| Q | E Andreeva | 6 | 77 | Q | E Andreeva | 78 | 2 | 3 | |||||||||||||||||||
| 4 | O Dodin | 3 | 65 | C Bucșa | 3 | 2 | |||||||||||||||||||||
| 7 | Y In-Albon | 65 | 4 | S Errani | 6 | 6 | |||||||||||||||||||||
| Q | A Robbe | 77 | 6 | Q | A Robbe | 67 | 1 | ||||||||||||||||||||
 F Contreras Gómez | 64 | 61 | Q | C Rosatello | 79 | 6 | |||||||||||||||||||||
| Q | C Rosatello | 77 | 77 | Q | C Rosatello | 2 | 3 | ||||||||||||||||||||
| O Selekhmeteva | 65 | 3 | S Errani | 6 | 6 | ||||||||||||||||||||||
| S Errani | 77 | 6 | S Errani | 2 | 6 | 6 | |||||||||||||||||||||
 O Danilović | 6 | 6 | O Danilović | 6 | 2 | 4 | |||||||||||||||||||||
| 2 | V Gracheva | 4 | 2 | ||||||||||||||||||||||||
Erika Andreeva (qualified) Natalia Vikhlyantseva (qualifying competition, retired) Camilla Rosatello (qualified) Alice Robbe (qualified)| Qualifying competition | ||||||
| 1 | Erika Andreeva | 7 | 77 | |||
| WC | Caroline Roméo | 5 | 64 | |||
| Qualifying competition | ||||||
| 2 | Natalia Vikhlyantseva | 0 | 0r | |||
| Lena Papadakis | 6 | 4 | ||||
| Qualifying competition | ||||||
| 3 | Camilla Rosatello | 6 | 6 | |||
| Émeline Dartron | 3 | 2 | ||||
| Qualifying competition | ||||||
| 4/WC | Alice Robbe | 6 | 6 | |||
 Nika Radišić | 4 | 1 | ||||
Marie Bouzková was the defending champion, but she chose not to participate. Dalma Gálfi won the title, defeating Sofia Kenin in the final, 7–5, 6–4.
Irina Falconi was the defending champion, but lost in the first round to Dalila Jakupović.
Samantha Stosur was the defending champion but lost in the quarterfinals to Dominika Cibulková.
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Tamara Zidanšek was the two-time defending champion, having won the last edition in 2019, however she was unable to defend her title as she was still competing at the 2021 French Open, reaching the semi-final of the Grand Slam.
This was the first edition of the tournament.
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