The knockout stage of the 2022 Women's Africa Cup of Nations began on 13 July 2022 with the quarter-finals and ended on 23 July 2022 with the final.
In the knockout phase, if a match is level at the end of 90 minutes of normal playing time, extra time is played (two periods of 15 minutes each), where each team is allowed to make a fourth substitution. If still tied after extra time, the match is decided by a penalty shoot-out to determine the winners. In the repêchage and third-place play-offs no extra time is played and the match is decided by a direct penalty shootout.
The top two placed teams from each of the three groups, along with the two best-placed third teams, qualified for the knockout stage.
| Group | Winners | Runners-up | Third-placed teams (Best two qualify) |
|---|---|---|---|
| A |  Morocco |  Senegal | — |
| B |  Zambia |  Cameroon |  Tunisia |
| C |  South Africa |  Nigeria |  Botswana |
| Quarter finals | Semi finals | Final | ||||||||
| 13 July – Rabat (Prince Moulay Abdellah) | ||||||||||
| Morocco | 2 | |||||||||
| 18 July – Rabat (Prince Moulay Abdellah) | ||||||||||
| Botswana | 1 | |||||||||
| Morocco (p) | 1 (5) | |||||||||
| 14 July – Casablanca | ||||||||||
| Nigeria | 1 (4) | |||||||||
| Cameroon | 0 | |||||||||
| 23 July – Rabat (Prince Moulay Abdellah) | ||||||||||
| Nigeria | 1 | |||||||||
| Morocco | 1 | |||||||||
| 13 July – Casablanca | ||||||||||
| South Africa | 2 | |||||||||
| Zambia (p) | 1 (4) | |||||||||
| 18 July – Casablanca | ||||||||||
| Senegal | 1 (2) | |||||||||
| Zambia | 0 | |||||||||
| 14 July – Rabat (Moulay Hassan) | ||||||||||
| South Africa | 1 | Third place | ||||||||
| South Africa | 1 | |||||||||
| 22 July – Casablanca | ||||||||||
| Tunisia | 0 | |||||||||
| Nigeria | 0 | |||||||||
| Zambia | 1 | |||||||||
| Repechage | ||||||||||
| 17 July – Rabat (Moulay Hassan) | ||||||||||
| Botswana | 0 | |||||||||
| Cameroon | 1 | |||||||||
| 17 July – Casablanca | ||||||||||
| Senegal (p) | 0 (4) | |||||||||
| Tunisia | 0 (2) | |||||||||
The winners qualified for the 2023 FIFA Women's World Cup.
| Zambia | 1–1 (a.e.t.) | Senegal |
|---|---|---|
| Report (FIFA) Report (CAF) |
|
| Penalties | ||
| 4–2 | ||
| Morocco | 2–1 | Botswana |
|---|---|---|
| Report (FIFA) Report (CAF) |
|
| Cameroon | 0–1 | Nigeria |
|---|---|---|
| Report (FIFA) Report (CAF) |
|
| South Africa | 1–0 | Tunisia |
|---|---|---|
| Report (FIFA) Report (CAF) |
| Zambia | 0–1 | South Africa |
|---|---|---|
| Report (FIFA) Report (CAF) |
| Nigeria | 0–1 | Zambia |
|---|---|---|
| Report (FIFA) Report (CAF) |
| Morocco | 1–2 | South Africa |
|---|---|---|
Ayane  80' | Report (FIFA) Report (CAF) | Magaia 63', 71' |
The losers of the quarter finals played-off against each other in a single match direct elimination format; the winners advanced to the inter-confederation play-offs.
| Senegal | 0–0 | Tunisia |
|---|---|---|
| Report (FIFA) Report (CAF) | ||
| Penalties | ||
| 4–2 | ||
| Botswana | 0–1 | Cameroon |
|---|---|---|
| Report (FIFA) Report (CAF) |
|
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| Editions | |
|---|---|
| Qualification | |
| Finals |
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| Squads | |
