The knockout stage of the 2022 Women's Africa Cup of Nations was the second and final stage of the competition, following the group stage. It began on 13 July with the quarter-finals and ended on 23 July 2022 with the final held at the Prince Moulay Abdellah Stadium in Rabat. A total of eight teams (the top two teams from each group, along with the two best third-placed teams) advanced to the knockout stage to compete in a single-elimination style tournament.
In the knockout phase, if a match is level at the end of 90 minutes of normal playing time, extra time is played (two periods of 15 minutes each), where each team is allowed to make a fourth substitution. If still tied after extra time, the match is decided by a penalty shoot-out to determine the winners. In the repêchage and third-place play-offs no extra time is played and the match is decided by a direct penalty shootout.
The top two placed teams from each of the three groups, along with the two best-placed third teams, qualified for the knockout stage.
| Group | Winners | Runners-up | Third-placed teams (Best two qualify) |
|---|---|---|---|
| A |  Morocco |  Senegal | — |
| B |  Zambia |  Cameroon |  Tunisia |
| C |  South Africa |  Nigeria |  Botswana |
| Quarter finals | Semi finals | Final | ||||||||
| 13 July – Rabat (Prince Moulay Abdellah) | ||||||||||
| Morocco | 2 | |||||||||
| 18 July – Rabat (Prince Moulay Abdellah) | ||||||||||
| Botswana | 1 | |||||||||
| Morocco (p) | 1 (5) | |||||||||
| 14 July – Casablanca | ||||||||||
| Nigeria | 1 (4) | |||||||||
| Cameroon | 0 | |||||||||
| 23 July – Rabat (Prince Moulay Abdellah) | ||||||||||
| Nigeria | 1 | |||||||||
| Morocco | 1 | |||||||||
| 13 July – Casablanca | ||||||||||
| South Africa | 2 | |||||||||
| Zambia (p) | 1 (4) | |||||||||
| 18 July – Casablanca | ||||||||||
| Senegal | 1 (2) | |||||||||
| Zambia | 0 | |||||||||
| 14 July – Rabat (Moulay Hassan) | ||||||||||
| South Africa | 1 | Third place | ||||||||
| South Africa | 1 | |||||||||
| 22 July – Casablanca | ||||||||||
| Tunisia | 0 | |||||||||
| Nigeria | 0 | |||||||||
| Zambia | 1 | |||||||||
| Repechage | ||||||||||
| 17 July – Rabat (Moulay Hassan) | ||||||||||
| Botswana | 0 | |||||||||
| Cameroon | 1 | |||||||||
| 17 July – Casablanca | ||||||||||
| Senegal (p) | 0 (4) | |||||||||
| Tunisia | 0 (2) | |||||||||
The winners qualified for the 2023 FIFA Women's World Cup.
| Zambia | 1–1 (a.e.t.) | Senegal |
|---|---|---|
| Report (FIFA) Report (CAF) |
|
| Penalties | ||
| 4–2 | ||
| Morocco | 2–1 | Botswana |
|---|---|---|
| Report (FIFA) Report (CAF) |
|
| Cameroon | 0–1 | Nigeria |
|---|---|---|
| Report (FIFA) Report (CAF) |
|
| South Africa | 1–0 | Tunisia |
|---|---|---|
| Report (FIFA) Report (CAF) |
| Zambia | 0–1 | South Africa |
|---|---|---|
| Report (FIFA) Report (CAF) |
| Nigeria | 0–1 | Zambia |
|---|---|---|
| Report (FIFA) Report (CAF) |
| Morocco | 1–2 | South Africa |
|---|---|---|
Ayane  80' | Report (FIFA) Report (CAF) | Magaia 63', 71' |
The losers of the quarter finals played-off against each other in a single match direct elimination format; the winners advanced to the inter-confederation play-offs.
| Senegal | 0–0 | Tunisia |
|---|---|---|
| Report (FIFA) Report (CAF) | ||
| Penalties | ||
| 4–2 | ||
| Botswana | 0–1 | Cameroon |
|---|---|---|
| Report (FIFA) Report (CAF) |
|
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| Editions | |
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| Qualification | |
| Finals |
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| Squads | |
