C. Alphonso Smith (1864–1924), American English professor, college dean, philologist and folklorist
Alfonso Soriano (born 1976), American Major League Baseball player
Alphonso Sumner, African American newspaper publisher and abolitionist who opened Nashville, Tennessee's first Black school in 1833
Alphonso Taft (1810–1891), American jurist, diplomat, and politician, United States Attorney General and Secretary of War under President Ulysses S. Grant, father of President William Howard Taft
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