Bipolar disorder, previously known as manic depression, is a mood disorder characterized by periods of depression and periods of abnormally-elevated happiness that last from days to weeks each. If the elevated mood is severe or associated with psychosis, it is called mania; if it is less severe, it is called hypomania. During mania, an individual behaves or feels abnormally energetic, happy or irritable, and they often make impulsive decisions with little regard for the consequences. There is usually also a reduced need for sleep during manic phases. During periods of depression, the individual may experience crying and have a negative outlook on life and poor eye contact with others. The risk of suicide is high; over a period of 20 years, 6% of those with bipolar disorder died by suicide, while 30–40% engaged in self-harm. Other mental health issues, such as anxiety disorders and substance use disorders, are commonly associated with bipolar disorder.
A mood disorder, also known as an affective disorder, is any of a group of conditions of mental and behavioral disorder where a disturbance in the person's mood is the main underlying feature. The classification is in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and International Classification of Diseases (ICD).
Links between creativity and mental health have been extensively discussed and studied by psychologists and other researchers for centuries. Parallels can be drawn to connect creativity to major mental disorders including bipolar disorder, schizophrenia, major depressive disorder, anxiety disorder, OCD and ADHD. For example, studies have demonstrated correlations between creative occupations and people living with mental illness. There are cases that support the idea that mental illness can aid in creativity, but it is also generally agreed that mental illness does not have to be present for creativity to exist.
The Institute of Psychiatry, Psychology and Neuroscience (IoPPN) is a research institution dedicated to discovering what causes mental illness and diseases of the brain. In addition, its aim is to help identify new treatments for them and ways to prevent them in the first place. The IoPPN is a faculty of King's College London, England, previously known as the Institute of Psychiatry (IoP).
Psychotic depression, also known as depressive psychosis, is a major depressive episode that is accompanied by psychotic symptoms. It can occur in the context of bipolar disorder or major depressive disorder. It can be difficult to distinguish from schizoaffective disorder, a diagnosis that requires the presence of psychotic symptoms for at least two weeks without any mood symptoms present. Unipolar psychotic depression requires that the psychotic features occur only during episodes of major depression. Diagnosis using the DSM-5 involves meeting the criteria for a major depressive episode, along with the criteria for "mood-congruent or mood-incongruent psychotic features" specifier.
Sir Michael Llewellyn Rutter CBE FRS FRCP FRCPsych FMedSci was the first person to be appointed professor of child psychiatry in the United Kingdom. He has been described as the "father of child psychology". Rutter was professor of developmental psychopathology at the Institute of Psychiatry, King's College London and consultant psychiatrist at the Maudsley Hospital, a post he held since 1966, until retiring in July 2021. A Review of General Psychology survey, published in 2002, ranked Rutter as the 68th most cited psychologist of the 20th century. He died of cancer on October 23, 2021, aged 88.
Peter McGuffin is a psychiatrist and geneticist from Belfast, Northern Ireland.
A spectrum disorder is a mental disorder that includes a range of linked conditions, sometimes also extending to include singular symptoms and traits. The different elements of a spectrum either have a similar appearance or are thought to be caused by the same underlying mechanism. In either case, a spectrum approach is taken because there appears to be "not a unitary disorder but rather a syndrome composed of subgroups". The spectrum may represent a range of severity, comprising relatively "severe" mental disorders through to relatively "mild and nonclinical deficits".
Martin Keller is an American psychiatrist. He is Professor Emeritus of Psychiatry and Human Behavior at Brown Medical School in Providence, Rhode Island.
Irving Isadore Gottesman was an American professor of psychology who devoted most of his career to the study of the genetics of schizophrenia. He wrote 17 books and more than 290 other publications, mostly on schizophrenia and behavioral genetics, and created the first academic program on behavioral genetics in the United States. He won awards such as the Hofheimer Prize for Research, the highest award from the American Psychiatric Association for psychiatric research. Lastly, Gottesman was a professor in the psychology department at the University of Minnesota, where he received his Ph.D.
Frederick King Goodwin was an American psychiatrist and Clinical Professor of Psychiatry at the George Washington University Medical Center, where he is also director of the Center on Neuroscience, Medical Progress, and Society. He is a specialist in bipolar disorder and recurrent depression.
Biological psychopathology is the study of the biological etiology of mental illnesses with a particular emphasis on the genetic and neurophysiological basis of clinical psychology. Biological psychopathology attempts to explain psychiatric disorders using multiple levels of analysis from the genome to brain functioning to behavior. Although closely related to clinical psychology, it is fundamentally an interdisciplinary approach that attempts to synthesize methods across fields such as neuroscience, psychopharmacology, biochemistry, genetics, and physiology. It is known by several alternative names, including "clinical neuroscience" and "experimental psychopathology." Due to the focus on biological processes of the central and peripheral nervous systems, biological psychopathology has been important in developing new biologically-based treatments for mental disorders.
Janet Treasure, OBE PhD FRCP FRCPsych, is a British psychiatrist, who specialises in research and treatment of eating disorders.
Thalia Catherine Eley is a Professor of Developmental Behavioural Genetics at the Institute of Psychiatry's MRC Social, Genetic and Developmental Psychiatry Centre, King's College London. Her work focuses on the interplay between genetic and environmental factors on the development and treatment of anxiety and depression.
Elliot S. Gershon is a professor of psychiatry and human genetics at the University of Chicago in the United States. He served as chair of its department of psychiatry from 1998 to 2004, and chief of the Clinical Neurogenetics branch of the NIMH. He held a NARSAD distinguished investigator grant from 1998 to 2006, and won the 1996 Falcone prize for Outstanding Achievement in Affective Disorders Research.
Lori Altshuler was a Professor at the University of California, Los Angeles (UCLA) Department of Psychiatry and Biobehavioral Sciences and held the Julia S. Gouw Endowed Chair for Mood Disorders. Altshuler was the Director of the UCLA Mood Disorders Research Program and the UCLA Women's Life Center, each being part of the Neuropsychiatric Hospital at UCLA.
Carmine Maria Pariante FRCPsych is professor of biological psychiatry at the Institute of Psychiatry at King's College, London, and consultant perinatal psychiatrist at the South London and Maudsley NHS Trust. He also works as the lead for the Affective Disorders and Interface with Medicine theme at the National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre (BRC).
Kate Tchanturia is a Professor of Psychology in Eating Disorders at the Institute of Psychiatry, Psychology and Neuroscience, King’s College London. She is also Consultant Psychologist at the South London and Maudsley NHS Foundation Trust for the National Eating Disorder Service London, United Kingdom. Her main research interests include cultural differences in illness presentations, cognitive profiles in eating disorders, and experimental work in emotion processing and translational research from experimental findings to real clinical practice. Tchanturia has a particular interest in women’s mental health and has pioneered the novel pathway for the autism spectrum condition (ASC) and eating disorder comorbidity.
Unipolar mania is an unrecognized mental illness characterized by episodes of mania and normal mood, with the absence of depressive symptoms. The concept has its origins as far back as the year 1889, when the German psychiatrist Emil Kraepelin first used the term of "periodic mania" to refer to people with recurrent manic episodes and no depression. One year later, Carl Wernicke proposed that mania and depression should be viewed as separate disorders. As the time went on, unipolar mania became an invalid diagnosis due to its variations across different patients. Currently patients with symptoms of mania, even in the absence of any depressive symptoms, would get the bipolar 1 diagnosis.
Diana Prata is a Portuguese neuroscientist who concentrates on identifying the biological basis of human behaviour. She reported the first evidence that schizophrenia-risk genes can also predispose to bipolar disorder and has also investigated reasons why people respond differently to antipsychotic medications. She is head of the Biomedical Neuroscience Lab at the University of Lisbon.
