The Australian Centre for Disease Preparedness (ACDP), formerly known as the Australian Animal Health Laboratory (AAHL), in Geelong, Victoria, Australia is a high security laboratory, run by the CSIRO for exotic animal disease diagnosis and research. The lab is one of four Biosafety Level-4 labs in the country.
It opened in 1985 costing $185 million, built on Corio Oval. [1]
In November 2012 it delivered an experimental vaccine to help protect horses against the deadly Hendra virus. [2]
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In 1977, Jim Peacock of the Australian Academy of Science asked Bill Snowdon, then Chief CSIRO AAHL if he could have the newly released USA NIH and the British equivalent requirements for the development of infrastructure for bio-containment reviewed by AAHL personnel with a view to recommending the adoption of one of them by Australian authorities. The review was carried out by CSIRO AAHL Project Manager Bill Curnow and CSIRO Engineer Arthur Jenkins. They drafted outcomes for each of the levels of security. AAHL was notionally classified as "substantially beyond P4". These were adopted by the Australian Academy of Science and became the basis for Australian Legislation.
The Australian Centre for Disease Preparedness was commissioned in 1985 as the Australian Animal Health Laboratory, [3] includes a number of laboratories and animal house facilities capable of operating at three steps of negative pressure below the lowest pressure within any part of the extramural wind-zone of the building exterior. External pressure and the cascaded negative pressure zones are measured and maintained in real time by electronic sensors, electronically controlled supply and exhaust air handling systems and purpose developed predictive logic controllers in support of management protocols to manage air locks, access and services to prevent loss or ingress of potentially contaminated gases, solids or liquids . Supply air is protected by two 0.001 HEPA filters in tandem, (series mounted) with appropriate pre-filters in purpose designed individual housings. Filters and housings in pairs are then mounted as multiples in parallel according to airflow and volume requirement. This configuration allows the de-contamination, testing and/or replacement of any individual filter without the need to shut down operation. For exhaust air, similar filtration hardware and management arrangements apply. However, at least one stage of exhaust protection of a method not relying on filtration is provided. In the case of AAHL, the system adopted by CSIRO was "air incineration" at 1000 C and a retention/dwell time of more than 4 seconds at that temperature. Liquid scrubbing to prevent escape of formaldehyde is fitted after the afterburner for protection of the environment. Waste liquids can be dosed chemically in steam jacketed stainless steel tanks as the first barrier, followed by heating under pressure and maintained at elevated temperature for an appropriate time. Multiple tanks can be configured in tandem or in parallel according to need.
AAHL was designed and built before there were any regulations covering bio-containment. The later regulations were written by AAHL personnel. AAHL Staff were at pains to ensure that AAHL could contain any known or yet to be discovered organism. Politically there was opposition to the notion of having the facility at all. The Prime Minister Malcolm Fraser, although in favor of the project, threatened serious consequences for management if the design team "got it wrong".
Innovation in the design delivered cost savings of between $30M and $50M so the design team felt that it was better to err on the safe side than to face the prospect of an angry PM. AAHL was very cost effective and safe as a result.[ citation needed ] The Australian Animal Health Laboratory is a Class 4/ P4 Laboratory.
The facility was renamed to the Australian Centre for Disease Preparedness in April 2020. [4]
Filtration is a physical separation process that separates solid matter and fluid from a mixture using a filter medium that has a complex structure through which only the fluid can pass. Solid particles that cannot pass through the filter medium are described as oversize and the fluid that passes through is called the filtrate. Oversize particles may form a filter cake on top of the filter and may also block the filter lattice, preventing the fluid phase from crossing the filter, known as blinding. The size of the largest particles that can successfully pass through a filter is called the effective pore size of that filter. The separation of solid and fluid is imperfect; solids will be contaminated with some fluid and filtrate will contain fine particles. Filtration occurs both in nature and in engineered systems; there are biological, geological, and industrial forms.
Heating, ventilation, and air conditioning (HVAC) is the use of various technologies to control the temperature, humidity, and purity of the air in an enclosed space. Its goal is to provide thermal comfort and acceptable indoor air quality. HVAC system design is a subdiscipline of mechanical engineering, based on the principles of thermodynamics, fluid mechanics, and heat transfer. "Refrigeration" is sometimes added to the field's abbreviation as HVAC&R or HVACR, or "ventilation" is dropped, as in HACR.
A biosafety level (BSL), or pathogen/protection level, is a set of biocontainment precautions required to isolate dangerous biological agents in an enclosed laboratory facility. The levels of containment range from the lowest biosafety level 1 (BSL-1) to the highest at level 4 (BSL-4). In the United States, the Centers for Disease Control and Prevention (CDC) have specified these levels. In the European Union, the same biosafety levels are defined in a directive. In Canada the four levels are known as Containment Levels. Facilities with these designations are also sometimes given as P1 through P4, as in the term P3 laboratory.
A biological hazard, or biohazard, is a biological substance that poses a threat to the health of living organisms, primarily humans. This could include a sample of a microorganism, virus or toxin that can adversely affect human health. A biohazard could also be a substance harmful to other living beings.
A fume hood is a type of local ventilation device that is designed to limit exposure to hazardous or toxic fumes, vapors or dusts.
Microfiltration is a type of physical filtration process where a contaminated fluid is passed through a special pore-sized membrane filter to separate microorganisms and suspended particles from process liquid. It is commonly used in conjunction with various other separation processes such as ultrafiltration and reverse osmosis to provide a product stream which is free of undesired contaminants.
Sterilization refers to any process that removes, kills, or deactivates all forms of life and other biological agents such as prions present in or on a specific surface, object, or fluid. Sterilization can be achieved through various means, including heat, chemicals, irradiation, high pressure, and filtration. Sterilization is distinct from disinfection, sanitization, and pasteurization, in that those methods reduce rather than eliminate all forms of life and biological agents present. After sterilization, an object is referred to as being sterile or aseptic.
Hendra virus (HeV), scientific name Hendra henipavirus, is a bat-borne virus that is associated with a highly fatal infection in horses and humans. Numerous disease outbreaks in Australia among horses have been caused by Hendra virus. The Hendra virus belongs to the genus Henipavirus, which also contains the Nipah virus, which has also caused disease outbreaks.
The National Microbiology Laboratory (NML) is part of the Public Health Agency of Canada (PHAC), the agency of the Government of Canada that is responsible for public health, health emergency preparedness and response, and infectious and chronic disease control and prevention.
A dust collector is a system used to enhance the quality of air released from industrial and commercial processes by collecting dust and other impurities from air or gas. Designed to handle high-volume dust loads, a dust collector system consists of a blower, dust filter, a filter-cleaning system, and a dust receptacle or dust removal system. It is distinguished from air purifiers, which use disposable filters to remove dust.
A Rotary Vacuum Filter Drum consists of a cylindrical filter membrane that is partly sub-merged in a slurry to be filtered. The inside of the drum is held lower than the ambient pressure. As the drum rotates through the slurry, the liquid is sucked through the membrane, leaving solids to cake on the membrane surface while the drum is submerged. A knife or blade is positioned to scrape the product from the surface.
An industrial filter press is a tool used in separation processes, specifically to separate solids and liquids. The machine stacks many filter elements and allows the filter to be easily opened to remove the filtered solids, and allows easy cleaning or replacement of the filter media.
The Canadian Science Centre for Human and Animal Health (CSCHAH) is an infectious disease laboratory complex in Winnipeg, Manitoba, owned and operated by the Government of Canada. This modern facility is home to two laboratories: the Public Health Agency of Canada's National Microbiology Laboratory (NML) and the Canadian Food Inspection Agency's National Centre for Foreign Animal Disease (NCFAD). It is the workplace of approximately 500 federal employees.
A vacuum ceramic filter is designed to separate liquids from solids for dewatering of ore concentrates purposes. The device consists of a rotator, slurry tank, ceramic filter plate, distributor, discharge scraper, cleaning device, frame, agitating device, pipe system, vacuum system, automatic acid dosing system, automatic lubricating system, valve and discharge chute. The operation and construction principle of vacuum ceramic filter resemble those of a conventional disc filter, but the filter medium is replaced by a finely porous ceramic disc. The disc material is inert, has a long operational life and is resistant to almost all chemicals. Performance can be optimized by taking into account all those factors which affect the overall efficiency of the separation process. Some of the variables affecting the performance of a vacuum ceramic filter include the solid concentration, speed rotation of the disc, slurry level in the feed basin, temperature of the feed slurry, and the pressure during dewatering stages and filter cake formation.
A hypoallergenic vacuum cleaner is a vacuum cleaner with filters designed to retain the vast majority of particles within the vacuum system. If successful this retention would greatly reduce the amount of potential allergens in the environment in which it is used. Regular vacuum cleaners are unable to retain most very fine dust and many allergens which simply are too small for the system to trap and are released from the system along with the exhaust air.
A biosafety cabinet (BSC)—also called a biological safety cabinet or microbiological safety cabinet—is an enclosed, ventilated laboratory workspace for safely working with materials contaminated with pathogens requiring a defined biosafety level. Several different types of BSC exist, differentiated by the degree of biocontainment they provide. BSCs first became commercially available in 1950.
The United States biological defense program—in recent years also called the National Biodefense Strategy—refers to the collective effort by all levels of government, along with private enterprise and other stakeholders, in the United States to carry out biodefense activities.
The National Centre for Foreign Animal Disease (NCFAD), located in the Canadian Science Centre for Human and Animal Health in Winnipeg, Manitoba, is part of the Canadian Food Inspection Agency’s National Centres for Animal Disease. NCFAD is co-located with the Public Health Agency of Canada’s National Microbiology Laboratory.
Engineering controls are strategies designed to protect workers from hazardous conditions by placing a barrier between the worker and the hazard or by removing a hazardous substance through air ventilation. Engineering controls involve a physical change to the workplace itself, rather than relying on workers' behavior or requiring workers to wear protective clothing.
Engineering controls for nanomaterials are a set of hazard control methods and equipment for workers who interact with nanomaterials. Engineering controls are physical changes to the workplace that isolate workers from hazards, and are considered the most important set of methods for controlling the health and safety hazards of nanomaterials after systems and facilities have been designed.