Autophagic cell death

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Autophagic cell death (ACD) is a controversial form of programmed cell death that is morphologically distinct from apoptosis and necrosis. [1] [2] While autophagy is generally considered a cellular survival mechanism, ACD occurs when excessive or dysregulated autophagy leads to the cell's demise. [3] This type of cell death is characterized by the large-scale accumulation of autophagosomes, giving the cell a vacuolated appearance. [1] However, the exact mechanisms and circumstances under which autophagy transitions from a protective process to a lethal one remain subjects of ongoing debate. [4]

References

  1. 1 2 Kroemer G, Levine B (December 2008). "Autophagic cell death: the story of a misnomer". Nature Reviews. Molecular Cell Biology. 9 (12): 1004–10. doi:10.1038/nrm2529. PMC   2727358 . PMID   18971948.
  2. ↑ Lenardo MJ, McPhee CK, Yu L (2009). "Autophagic cell death". Methods in Enzymology. 453: 17–31. doi:10.1016/S0076-6879(08)04002-0. PMC   3417315 . PMID   19216900.
  3. ↑ Liu S, Yao S, Yang H, Liu S, Wang Y (October 2023). "Autophagy: Regulator of cell death". Cell Death & Disease. 14 (10): 648. doi:10.1038/s41419-023-06154-8. PMC   10551038 . PMID   37794028.
  4. ↑ Denton D, Nicolson S, Kumar S (January 2012). "Cell death by autophagy: facts and apparent artefacts". Cell Death and Differentiation. 19 (1): 87–95. doi:10.1038/cdd.2011.146. PMC   3252836 . PMID   22052193.
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