Bacopaside

Last updated June 08, 2025

Bacopasides are triterpene saponins isolated from Bacopa monnieri .

Members of this class of compounds include:

Bacopaside I, shows antidepressant-like effects in a mouse model ^[1]
Bacopaside II^[2]
Bacopaside III^[3]^[4]
Bacopaside IV^[4]
Bacopaside V^[4]
Bacopaside VI^[5]
Bacopaside VII^[5]
Bacopaside VIII^[5]
Bacopaside IX^[6]
Bacopaside X^[6]
Bacopaside XI, shows nootropic activity in a mouse model^[6]

References

↑ Liu, X; Liu, F; Yue, R; Li, Y; Zhang, J; Wang, S; Zhang, S; Wang, R; Shan, L; Zhang, W (2013). "The antidepressant-like effect of bacopaside I: Possible involvement of the oxidative stress system and the noradrenergic system". Pharmacology Biochemistry and Behavior. 110: 224–30. doi:10.1016/j.pbb.2013.07.007. PMID 23872136. S2CID 23612866.
↑ Chakravarty, AK; Sarkar, T; Masuda, K; Shiojima, K; Nakane, T; Kawahara, N (2001). "Bacopaside I and II: Two pseudojujubogenin glycosides from Bacopa monniera". Phytochemistry. 58 (4): 553–6. doi:10.1016/S0031-9422(01)00275-8. PMID 11576596.
↑ Hou, CC; Lin, SJ; Cheng, JT; Hsu, FL (2002). "Bacopaside III, bacopasaponin G, and bacopasides A, B, and C from Bacopa monniera". Journal of Natural Products. 65 (12): 1759–63. doi:10.1021/np020238w. PMID 12502309.
1 2 3 Chakravarty, AK; Garai, S; Masuda, K; Nakane, T; Kawahara, N (2003). "Bacopasides III-V: Three new triterpenoid glycosides from Bacopa monniera". Chemical & Pharmaceutical Bulletin. 51 (2): 215–7. doi: 10.1248/cpb.51.215 . PMID 12576661.
1 2 3 Zhou, Y; Shen, YH; Zhang, C; Su, J; Liu, RH; Zhang, WD (2007). "Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models". Journal of Natural Products. 70 (4): 652–5. doi:10.1021/np060470s. PMID 17343408.
1 2 3 Zhou, Y; Peng, L; Zhang, WD; Kong, DY (2009). "Effect of triterpenoid saponins from Bacopa monniera on scopolamine-induced memory impairment in mice". Planta Medica. 75 (6): 568–74. doi:10.1055/s-0029-1185339. PMID 19214943.

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[1] Liu, X; Liu, F; Yue, R; Li, Y; Zhang, J; Wang, S; Zhang, S; Wang, R; Shan, L; Zhang, W (2013). "The antidepressant-like effect of bacopaside I: Possible involvement of the oxidative stress system and the noradrenergic system". Pharmacology Biochemistry and Behavior. 110: 224–30. doi:10.1016/j.pbb.2013.07.007. PMID 23872136. S2CID 23612866.

[2] Chakravarty, AK; Sarkar, T; Masuda, K; Shiojima, K; Nakane, T; Kawahara, N (2001). "Bacopaside I and II: Two pseudojujubogenin glycosides from Bacopa monniera". Phytochemistry. 58 (4): 553–6. doi:10.1016/S0031-9422(01)00275-8. PMID 11576596.

[3] Hou, CC; Lin, SJ; Cheng, JT; Hsu, FL (2002). "Bacopaside III, bacopasaponin G, and bacopasides A, B, and C from Bacopa monniera". Journal of Natural Products. 65 (12): 1759–63. doi:10.1021/np020238w. PMID 12502309.

[Chakravarty-4] 1 2 3 Chakravarty, AK; Garai, S; Masuda, K; Nakane, T; Kawahara, N (2003). "Bacopasides III-V: Three new triterpenoid glycosides from Bacopa monniera". Chemical & Pharmaceutical Bulletin. 51 (2): 215–7. doi: 10.1248/cpb.51.215 . PMID 12576661.

[Zhou-5] 1 2 3 Zhou, Y; Shen, YH; Zhang, C; Su, J; Liu, RH; Zhang, WD (2007). "Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models". Journal of Natural Products. 70 (4): 652–5. doi:10.1021/np060470s. PMID 17343408.

[Zhou2-6] 1 2 3 Zhou, Y; Peng, L; Zhang, WD; Kong, DY (2009). "Effect of triterpenoid saponins from Bacopa monniera on scopolamine-induced memory impairment in mice". Planta Medica. 75 (6): 568–74. doi:10.1055/s-0029-1185339. PMID 19214943.

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