Born in Bradford [1] is a large birth cohort study based at Bradford Royal Infirmary, a hospital in the city of Bradford, West Yorkshire in the United Kingdom. 12,500 pregnant women were recruited to the study between March 2007 and December 2010. The lives of their 13,500 children are being tracked through research studies and the use of routinely collected medical and educational data.
Bradford has some of the highest rates of childhood illness in the UK. Born in Bradford is helping to unravel the reasons for this ill health and bring new scientific discovery to the world. [2] It is also providing a catalyst for communities to work with the NHS and local authority to improve child health and wellbeing in the city. Examples of the success of Born in Bradford in changing practice include: the establishment of a Yorkshire wide congenital anomalies register, the first trust in the UK to provide gestational diabetes screening for all pregnant women in the district, improvement in vitamin D supplementation in high risk mothers, rapid implementation of NICE guidelines in midwifery practice, improved detection of childhood obesity by health visitors, and development of a simple mobile phone app to help parents and health professionals monitor children's weight.
Born in Bradford will continue to follow children until they are adults, and help doctors to understand more about the big health challenges of the 21st century such as heart disease, mental health and cancer. This is a study that has the potential to promote real change at a local level and also to make major contributions to global knowledge. [3]
The project does an annual programme on BBC Radio 4 hosted by Winifred Robinson. [4]
Teenage pregnancy, also known as adolescent pregnancy, is pregnancy in a female adolescent or young adult under the age of 20. Worldwide, pregnancy complications are the leading cause of death for women and girls 15 to 19 years old. The definition of teenage pregnancy includes those who are legally considered adults in their country. The WHO defines adolescence as the period between the ages of 10 and 19 years. Pregnancy can occur with sexual intercourse after the start of ovulation, which can happen before the first menstrual period (menarche). In healthy, well-nourished girls, the first period usually takes place between the ages of 12 and 13.
Fertility is the ability to conceive a child. The fertility rate is the average number of children born during an individual's lifetime and is quantified demographically. Conversely, infertility is the difficulty or inability to reproduce naturally. In general, infertility is defined as not being able to conceive a child after one year of unprotected sex. Infertility is widespread, with fertility specialists available all over the world to assist parents and couples who experience difficulties conceiving a baby.
A multivitamin is a preparation intended to serve as a dietary supplement with vitamins, dietary minerals, and other nutritional elements. Such preparations are available in the form of tablets, capsules, pastilles, powders, liquids, or injectable formulations. Other than injectable formulations, which are only available and administered under medical supervision, multivitamins are recognized by the Codex Alimentarius Commission as a category of food.
The Framingham Heart Study is a long-term, ongoing cardiovascular cohort study of residents of the city of Framingham, Massachusetts. The study began in 1948 with 5,209 adult subjects from Framingham, and is now on its third generation of participants. Prior to the study almost nothing was known about the epidemiology of hypertensive or arteriosclerotic cardiovascular disease. Much of the now-common knowledge concerning heart disease, such as the effects of diet, exercise, and common medications such as aspirin, is based on this longitudinal study. It is a project of the National Heart, Lung, and Blood Institute, in collaboration with Boston University. Various health professionals from the hospitals and universities of Greater Boston staff the project.
Child abuse is physical, sexual, emotional and/or psychological maltreatment or neglect of a child, especially by a parent or a caregiver. Child abuse may include any act or failure to act by a parent or a caregiver that results in actual or potential harm to a child and can occur in a child's home, or in organizations, schools, or communities the child interacts with.
Early childhood caries (ECC), formerly known as nursing bottle caries, baby bottle tooth decay, night bottle mouth and night bottle caries, is a disease that affects teeth in children aged between birth and 71 months. ECC is characterized by the presence of 1 or more decayed, missing, or filled tooth surfaces in any primary tooth. ECC has been shown to be a very common, transmissible bacterial infection, usually passed from the primary caregiver to the child.The main bacteria responsible for dental cavities are Streptococcus mutans (S.mutans) and Lactobacillus. There is also evidence that supports that those who are in lower socioeconomic populations are at greater risk of developing ECC.
Thiomersal is a mercury compound which is used as a preservative in some vaccines. Anti-vaccination activists promoting the incorrect claim that vaccination causes autism have asserted that the mercury in thiomersal is the cause. There is no scientific evidence to support this claim. The idea that thiomersal in vaccines might have detrimental effects originated with anti-vaccination activists and was sustained by them and especially through the action of plaintiffs' lawyers.
Childhood obesity is a condition where excess body fat negatively affects a child's health or well-being. As methods to determine body fat directly are difficult, the diagnosis of obesity is often based on BMI. Due to the rising prevalence of obesity in children and its many adverse health effects it is being recognized as a serious public health concern. The term overweight rather than obese is often used when discussing childhood obesity, as it is less stigmatizing, although the term overweight can also refer to a different BMI category. The prevalence of childhood obesity is known to differ by sex and gender.
The Avon Longitudinal Study of Parents and Children (ALSPAC), also known as Children of the 90s and formerly the Avon Longitudinal Study of Pregnancy and Childhood, is a cohort study of children born in the former county of Avon, England during 1991 and 1992. It is used by researchers in health, education and other social science disciplines.
Tobacco smoking during pregnancy causes many detrimental effects on health and reproduction, in addition to the general health effects of tobacco. A number of studies have shown that tobacco use is a significant factor in miscarriages among pregnant smokers, and that it contributes to a number of other threats to the health of the foetus.
Irva Hertz-Picciotto, is an environmental epidemiologist best known for her studies of autism. She is Professor and Chief, Division of Environmental and Occupational Health, Department of Public Health Sciences, at the University of California, Davis (UC-Davis). In addition, she is on the Research Faculty of the MIND Institute at UC-Davis; is Deputy Director of the UC-Davis Center for Children's Environmental Health; and is on the faculty of the Center for Occupational and Environmental Health of the Universities of California at Berkeley, Davis, and San Francisco. Hertz-Picciotto serves on the advisory board of the anti-toxic chemical NGO Healthy Child, Healthy World.
Catherine S. Peckham FFPHM is a British paediatrician.
Generation R is a prospective, population based cohort study from fetal life until young adulthood in a multi-ethnic urban population in Rotterdam, the Netherlands. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health. Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
Jean Golding, FMedSci, is a British epidemiologist, and founder of the Avon Longitudinal Study of Parents and Children (ALSPAC), also known as "Children of the Nineties". She is Emeritus Professor of Paediatric and Perinatal Epidemiology at the University of Bristol.
The Raine Study is one of the largest prospective cohorts of pregnancy, childhood, adolescence and now early adulthood to be carried out anywhere in the world. Its purpose is to improve human health and well-being, through the study of a cohort of Western Australians from before birth onwards.
Adverse childhood experiences (ACEs) include childhood emotional, physical, or sexual abuse and household dysfunction during childhood. The categories are verbal abuse, physical abuse, contact sexual abuse, a battered mother, household substance abuse, household mental illness, incarcerated household members, and parental separation or divorce. The experiences chosen were based upon prior research that has shown to them to have significant negative health or social implications, and for which substantial efforts are being made in the public and private sector to reduce their frequency of occurrence. Scientific evidence is mounting that such adverse childhood experiences (ACEs) have a profound long-term effect on health. Research shows that exposure to abuse and to serious forms of family dysfunction in the childhood family environment are likely to activate the stress response, thus potentially disrupting the developing nervous, immune, and metabolic systems of children. ACEs are associated with lifelong physical and mental health problems that emerge in adolescence and persist into adulthood, including cardiovascular disease, chronic obstructive pulmonary disease, autoimmune diseases, substance abuse, and depression.
Melissa Anne Wake MBChB MD FRACP FAHMS is a New Zealand paediatrician and Scientific Director of the Generation Victoria initiative, aiming to create very large, parallel whole-of-state birth and parent cohorts in Victoria, Australia, for Open Science discovery and interventional research. She is Group Leader of the Murdoch Children's Research Institute’s Prevention Innovation Research Group and holds Professorial positions with the University of Melbourne and the University of Auckland.
Lucas Alfred Derrick Tovey FRCPath, FRCOG, was a British pathologist who shortly after being appointed consultant at St Luke's Hospital in Bradford, West Yorkshire, England, recognised the first cases of smallpox in the early days of the Bradford smallpox outbreak of 1962. Over the subsequent three days a further eight cases of smallpox were detected and Tovey subsequently became in charge of infection control at St Luke's and given the responsibility of liaising with the medical officers of health and the press. He later attributed the successful containment of the outbreak to effective contact tracing, surveillance and vaccination.
The Growing Up in New Zealand longitudinal study (GUiNZ) is New Zealand's largest ongoing cohort study. It recruited and follows 6,846 New Zealand children born between 2009 and 2010—approximately 11 per cent of all children born in the country in that period. The project aims to create an in-depth summary of what life is like for children in New Zealand, and what factors affect their happiness, health, and development. The study also seeks to represent the diversity of modern-day New Zealand families, filling in current knowledge gaps on the health and wellbeing of Māori, Pasifika, and other communities. The study is run from the University of Auckland and is funded primarily by the New Zealand Government.
John Wright FRCP FFPH FRSA is a British specialist in epidemiology, an applied researcher, and a doctor in the National Health Service (NHS). He established the Bradford Institute for Health Research, based at Bradford Royal Infirmary, in 2007, based at the Bradford Teaching Hospitals NHS Foundation Trust.