Building block (chemistry)

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Construction of complex molecular architectures is easily possible using simple building blocks Molecular BB House 157.jpg
Construction of complex molecular architectures is easily possible using simple building blocks

Building block is a term in chemistry which is used to describe a virtual molecular fragment or a real chemical compound the molecules of which possess reactive functional groups. [1] Building blocks are used for bottom-up modular assembly of molecular architectures: nano-particles, [2] [3] metal-organic frameworks, [4] organic molecular constructs, supra-molecular complexes. [5] Using building blocks ensures strict control of what a final compound or a (supra)molecular construct will be. [6]

Contents

Building blocks for medicinal chemistry

In medicinal chemistry, the term defines either imaginable, virtual molecular fragments or chemical reagents from which drugs or drug candidates might be constructed or synthetically prepared. [7]

Virtual building blocks

Virtual building blocks are used in drug discovery for drug design and virtual screening, addressing the desire to have controllable molecular morphologies that interact with biological targets. [8] Of special interest for this purpose are the building blocks common to known biologically active compounds, in particular, known drugs, [9] or natural products. [10] There are algorithms for de novo design of molecular architectures by assembly of drug-derived virtual building blocks. [11]

Chemical reagents as building blocks

Organic functionalized molecules (reagents), carefully selected for the use in modular synthesis of novel drug candidates, in particular, by combinatorial chemistry, or in order to realize the ideas of virtual screening and drug design are also called building blocks. [12] [13] To be practically useful for the modular drug or drug candidate assembly, the building blocks should be either mono-functionalised or possessing selectively chemically addressable functional groups, for example, orthogonally protected. [14] Selection criteria applied to organic functionalized molecules to be included in the building block collections for medicinal chemistry are usually based on empirical rules aimed at drug-like properties of the final drug candidates. [15] [16] Bioisosteric replacements of the molecular fragments in drug candidates could be made using analogous building blocks. [17]

Building blocks and chemical industry

The building block approach to drug discovery changed the landscape of chemical industry which supports medicinal chemistry. [18] Major chemical suppliers for medicinal chemistry like Maybridge, [19] Chembridge, [20] Enamine [21] adjusted their business correspondingly. [22] By the end of the 1990th the use of building block collections prepared for fast and reliable construction of small-molecule sets of compounds (libraries) for biological screening became one of the major strategies for pharmaceutical industry involved in drug discovery; modular, usually one-step synthesis of compounds for biological screening from building blocks turned out to be in most cases faster and more reliable than multistep, even convergent syntheses of target compounds. [23]

There are online web-resources.

Examples

Typical examples of building block collections for medicinal chemistry are libraries of fluorine-containing building blocks. [24] [25] Introduction of the fluorine into a molecule has been shown to be beneficial for its pharmacokinetic and pharmacodynamic properties, therefore, the fluorine-substituted building blocks in drug design increase the probability of finding drug leads. [26] Other examples include natural and unnatural amino acid libraries, [27] collections of conformationally constrained bifunctionalized compounds [28] and diversity-oriented building block collections. [29]

An anti-diabetic drug Saxagliptin and two building blocks BB1 and BB2 from which it could be synthesized SaxagliptinBB.jpg
An anti-diabetic drug Saxagliptin and two building blocks BB1 and BB2 from which it could be synthesized

Related Research Articles

Combinatorial chemistry comprises chemical synthetic methods that make it possible to prepare a large number of compounds in a single process. These compound libraries can be made as mixtures, sets of individual compounds or chemical structures generated by computer software. Combinatorial chemistry can be used for the synthesis of small molecules and for peptides.

In molecular biology and pharmacology, a small molecule or micromolecule is a low molecular weight organic compound that may regulate a biological process, with a size on the order of 1 nm. Many drugs are small molecules; the terms are equivalent in the literature. Larger structures such as nucleic acids and proteins, and many polysaccharides are not small molecules, although their constituent monomers are often considered small molecules. Small molecules may be used as research tools to probe biological function as well as leads in the development of new therapeutic agents. Some can inhibit a specific function of a protein or disrupt protein–protein interactions.

<span class="mw-page-title-main">Drug discovery</span> Pharmaceutical procedure

In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.

Cheminformatics refers to the use of physical chemistry theory with computer and information science techniques—so called "in silico" techniques—in application to a range of descriptive and prescriptive problems in the field of chemistry, including in its applications to biology and related molecular fields. Such in silico techniques are used, for example, by pharmaceutical companies and in academic settings to aid and inform the process of drug discovery, for instance in the design of well-defined combinatorial libraries of synthetic compounds, or to assist in structure-based drug design. The methods can also be used in chemical and allied industries, and such fields as environmental science and pharmacology, where chemical processes are involved or studied.

<span class="mw-page-title-main">Drug design</span> Invention of new medications based on knowledge of a biological target

Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is sometimes referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals including peptides and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.

<span class="mw-page-title-main">Medicinal chemistry</span> Scientific branch of chemistry

Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR).

<span class="mw-page-title-main">Pharmacophore</span> Abstract description of molecular features

In medicinal chemistry and molecular biology, a pharmacophore is an abstract description of molecular features that are necessary for molecular recognition of a ligand by a biological macromolecule. IUPAC defines a pharmacophore to be "an ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target and to trigger its biological response". A pharmacophore model explains how structurally diverse ligands can bind to a common receptor site. Furthermore, pharmacophore models can be used to identify through de novo design or virtual screening novel ligands that will bind to the same receptor.

<span class="mw-page-title-main">Adamantane</span> Molecule with three connected cyclohexane rings arranged in the "armchair" configuration

Adamantane is an organic compound with a formula C10H16 or, more descriptively, (CH)4(CH2)6. Adamantane molecules can be described as the fusion of three cyclohexane rings. The molecule is both rigid and virtually stress-free. Adamantane is the most stable isomer of C10H16. The spatial arrangement of carbon atoms in the adamantane molecule is the same as in the diamond crystal. This similarity led to the name adamantane, which is derived from the Greek adamantinos (relating to steel or diamond). It is a white solid with a camphor-like odor. It is the simplest diamondoid.

<span class="mw-page-title-main">Chemical space</span>

Chemical space is a concept in cheminformatics referring to the property space spanned by all possible molecules and chemical compounds adhering to a given set of construction principles and boundary conditions. It contains millions of compounds which are readily accessible and available to researchers. It is a library used in the method of molecular docking.

<span class="mw-page-title-main">Macrocycle</span> Molecule with a large ring structure

Macrocycles are often described as molecules and ions containing a ring of twelve or more atoms. Classical examples include the crown ethers, calixarenes, porphyrins, and cyclodextrins. Macrocycles describe a large, mature area of chemistry.

In medicinal chemistry, bioisosteres are chemical substituents or groups with similar physical or chemical properties which produce broadly similar biological properties in the same chemical compound. In drug design, the purpose of exchanging one bioisostere for another is to enhance the desired biological or physical properties of a compound without making significant changes in chemical structure. The main use of this term and its techniques are related to pharmaceutical sciences. Bioisosterism is used to reduce toxicity, change bioavailability, or modify the activity of the lead compound, and may alter the metabolism of the lead.

<span class="mw-page-title-main">Virtual screening</span>

Virtual screening (VS) is a computational technique used in drug discovery to search libraries of small molecules in order to identify those structures which are most likely to bind to a drug target, typically a protein receptor or enzyme.

<span class="mw-page-title-main">Flufenamic acid</span> Chemical compound

Flufenamic acid (FFA) is a member of the anthranilic acid derivatives class of nonsteroidal anti-inflammatory drugs (NSAIDs). Like other members of the class, it is a cyclooxygenase (COX) inhibitor, preventing the formation of prostaglandins. FFA is known to bind to and reduce the activity of prostaglandin F synthase and activate TRPC6.

<span class="mw-page-title-main">Chemical similarity</span> Chemical term

Chemical similarity refers to the similarity of chemical elements, molecules or chemical compounds with respect to either structural or functional qualities, i.e. the effect that the chemical compound has on reaction partners in inorganic or biological settings. Biological effects and thus also similarity of effects are usually quantified using the biological activity of a compound. In general terms, function can be related to the chemical activity of compounds.

Inte:Ligand was founded in Maria Enzersdorf, Lower Austria (Niederösterreich) in 2003. They established the company headquarters on Mariahilferstrasse in Vienna, Austria that same year.

Fragment-based lead discovery (FBLD) also known as fragment-based drug discovery (FBDD) is a method used for finding lead compounds as part of the drug discovery process. Fragments are small organic molecules which are small in size and low in molecular weight. It is based on identifying small chemical fragments, which may bind only weakly to the biological target, and then growing them or combining them to produce a lead with a higher affinity. FBLD can be compared with high-throughput screening (HTS). In HTS, libraries with up to millions of compounds, with molecular weights of around 500 Da, are screened, and nanomolar binding affinities are sought. In contrast, in the early phase of FBLD, libraries with a few thousand compounds with molecular weights of around 200 Da may be screened, and millimolar affinities can be considered useful. FBLD is a technique being used in research for discovering novel potent inhibitors. This methodology could help to design multitarget drugs for multiple diseases. The multitarget inhibitor approach is based on designing an inhibitor for the multiple targets. This type of drug design opens up new polypharmacological avenues for discovering innovative and effective therapies. Neurodegenerative diseases like Alzheimer’s (AD) and Parkinson’s, among others, also show rather complex etiopathologies. Multitarget inhibitors are more appropriate for addressing the complexity of AD and may provide new drugs for controlling the multifactorial nature of AD, stopping its progression.

Topological inhibitors are rigid three-dimensional molecules of inorganic, organic, and hybrid compounds that form multicentered supramolecular interactions in vacant cavities of protein macromolecules and their complexes.

Matched molecular pair analysis (MMPA) is a method in cheminformatics that compares the properties of two molecules that differ only by a single chemical transformation, such as the substitution of a hydrogen atom by a chlorine one. Such pairs of compounds are known as matched molecular pairs (MMP). Because the structural difference between the two molecules is small, any experimentally observed change in a physical or biological property between the matched molecular pair can more easily be interpreted. The term was first coined by Kenny and Sadowski in the book Chemoinformatics in Drug Discovery.

Igor Volodymyrovych Komarov is a Ukrainian synthetic organic chemist, specializing in medicinal chemistry and nanotechnology. He is the director of the Institute of High Technologies of Taras Shevchenko National University of Kyiv. He is also a scientific advisor of Enamine Ltd (Ukraine) and Lumobiotics GmbH (Germany).

<span class="mw-page-title-main">Iwao Ojima</span>

Iwao Ojima is a Japanese-American chemist and university distinguished professor at the State University of New York at Stony Brook. He has been widely recognized for his seminal contributions to a range of chemical research at the multifaceted interfaces of chemical synthesis and life sciences. As rare accomplishments, he has received four National Awards from the American Chemical Society in four different fields of research. He is also serving as the director of the Institute of Chemical Biology and Drug Discovery (ICB&DD), as well as the president of the Stony Brook Chapter of the National Academy of Inventors.

References

  1. H.H. Szmant (1989). Organic Building Blocks of the Chemical Industry. New York: John Wiley & Sons.
  2. L. Zang; Y. Che; J.S. Moore (2008). "One-Dimensional Self-Assembly of Planar π-Conjugated Molecules: Adaptable Building Blocks for Organic Nanodevices". Acc. Chem. Res. 41 (12): 1596–1608. doi:10.1021/ar800030w. PMID   18616298.
  3. J.M.J. Fréchet (2003). "Dendrimers and other dendritic macromolecules: From building blocks to functional assemblies in nanoscience and nanotechnology". J. Polym. Sci. A Polym. Chem. 41 (23): 3713–3725. Bibcode:2003JPoSA..41.3713F. doi: 10.1002/pola.10952 .
  4. O. K. Farha; C. D. Malliakas; M.G. Kanatzidis; J.T. Hupp (2010). "Control over Catenation in Metal−Organic Frameworks via Rational Design of the Organic Building Block". J. Am. Chem. Soc. 132 (3): 950–952. doi:10.1021/ja909519e. PMID   20039671.
  5. A.J. Cairns; J.A. Perman; L. Wojtas; V.Ch. Kravtsov; M.H. Alkordi; M.Eddaoudi; M.J. Zaworotko (2008). "Supermolecular Building Blocks (SBBs) and Crystal Design: 12-Connected Open Frameworks Based on a Molecular Cubohemioctahedron". J. Am. Chem. Soc. 130 (5): 1560–1561. doi:10.1021/ja078060t. PMID   18186639.
  6. R.S. Tu; M. Tirrell (2004). "Bottom-up design of biomimetic assemblies". Adv. Drug Deliv. Rev. 56 (11): 1537–1563. doi:10.1016/j.addr.2003.10.047. PMID   15350288.
  7. G. Schneider; M.-L. Lee; M. Stahl; P. Schneider (2000). "De novo design of molecular architectures by evolutionary assembly of drug-derived building blocks". J. Comput.-Aided Mol. Des. 14 (5): 487–494. Bibcode:2000JCAMD..14..487S. doi:10.1023/A:1008184403558. PMID   10896320. S2CID   12380240.
  8. J. Wang; T. Hou (2010). "Drug and Drug Candidate Building Block Analysis". J. Chem. Inf. Model. 50 (1): 55–67. doi:10.1021/ci900398f. PMID   20020714. S2CID   24607262.
  9. A. Kluczyk; T. Popek; T. Kiyota; P. de Macedo; P. Stefanowicz; C. Lazar; Y. Konishi (2002). "Drug Evolution: p-Aminobenzoic Acid as a Building Block". Curr. Med. Chem. 9 (21): 1871–1892. doi:10.2174/0929867023368872. PMID   12369873.
  10. R.Breinbauer; I. R. Vetter; H.Waldmann (2002). "From Protein Domains to Drug Candidates—Natural Products as Guiding Principles in the Design and Synthesis of Compound Libraries". Angewandte Chemie International Edition. 41 (16): 2878–2890. doi:10.1002/1521-3773(20020816)41:16<2878::AID-ANIE2878>3.0.CO;2-B. PMID   12203413.
  11. G. Schneider; U. Fechner (2005). "Computer-based de novo design of drug-like molecules". Nat. Rev. Drug Discov. 4 (8): 649–663. doi:10.1038/nrd1799. PMID   16056391. S2CID   2549851.
  12. A. Linusson; J. Gottfries; F. Lindgren; S. Wold (2000). "Statistical Molecular Design of Building Blocks for Combinatorial Chemistry". J. Med. Chem. 43 (7): 1320–1328. doi:10.1021/jm991118x. PMID   10753469.
  13. G. Schneider; H.-J. Böhm (2002). "Virtual screening and fast automated docking methods". Drug Discovery Today. 7 (1): 64–70. doi:10.1016/S1359-6446(01)02091-8. PMID   11790605.
  14. A.N. Shivanyuk; D.M. Volochnyuk; I.V. Komarov; K.G. Nazarenko; D.S. Radchenko; A. Kostyuk; A.A. Tomachev (2007). "Conformationally restricted monoprotected diamines as scaffolds for design of biologically active compounds and peptidomimetics". Chimica Oggi/Chemistry Today. 25 (3): 12–13.
  15. I. Muegge (2003). "Selection criteria for drug-like compounds". Med. Res. Rev. 23 (3): 302–321. doi:10.1002/med.10041. PMID   12647312. S2CID   6236984.
  16. F.W. Goldberg; J.G. Kettle; T. Kogej; M.W.D. Perry; N.P. Tomkinson (2015). "Designing novel building blocks is an overlooked strategy to improve compound quality". Drug Discovery Today. 20 (1): 11–17. doi:10.1016/j.drudis.2014.09.023. PMID   25281855.
  17. A.V. Tymtsunik; V.A. Bilenko; S.O. Kokhan; O.O. Grygorenko; D.M. Volochnyuk; I.V. Komarov (2012). "1-Alkyl-5-((di)alkylamino) Tetrazoles: Building Blocks for Peptide Surrogates". J. Org. Chem. 77 (2): 1174–1180. doi:10.1021/jo2022235. PMID   22171684.
  18. "A MARKET GROWS, BLOCK BY BLOCK. Pharmaceutical building-block business attracts firms from ACROSS THE GLOBE". Chem. Eng. News. 89 (18): 16–18. 2011. doi:10.1021/cen-v089n018.p016.
  19. "Maybridge building blocks and reactive intermediates".
  20. "Building Blocks: Key Facts".
  21. "Building Blocks for Drug Discovery".
  22. Lowe, Derek (2010-03-18). "Good Suppliers – And The Other Guys".
  23. J. Drews (2000). "Drug Discovery: A Historical Perspective". Science. 287 (5460): 1960–1964. Bibcode:2000Sci...287.1960D. doi:10.1126/science.287.5460.1960. PMID   10720314.
  24. M Schlosser (2006). "CF3-Bearing Aromatic and Heterocyclic Building Blocks". Angewandte Chemie International Edition. 45 (33): 5432–5446. doi:10.1002/anie.200600449. PMID   16847982.
  25. V.S. Yarmolchuk; O.V. Shishkin; V.S. Starova; O.A. Zaporozhets; O. Kravchuk; S. Zozulya; I.V. Komarov; P.K. Mykhailiuk (2013). "Synthesis and Characterization of β-Trifluoromethyl-Substituted Pyrrolidines". Eur. J. Org. Chem. 2013 (15): 3086–3093. doi:10.1002/ejoc.201300121.
  26. I. Ojima (2009). Fluorine in Medicinal Chemistry and Chemical Biology. Blackwell Publishing. doi:10.1002/9781444312096.fmatter.
  27. I.V. Komarov; A.O. Grigorenko; A.V. Turov; V.P. Khilya (2004). "Conformationally rigid cyclic α-amino acids in the design of peptidomimetics, peptide models and biologically active compounds". Russian Chemical Reviews. 73 (8): 785–810. Bibcode:2004RuCRv..73..785K. doi:10.1070/rc2004v073n08abeh000912.
  28. O.O. Grygorenko; D.S. Radchenko; D.M. Volochnyuk; A.A. Tolmachev; I.V. Komarov (2011). "Bicyclic Conformationally Restricted Diamines". Chem. Rev. 111 (9): 5506–5568. doi:10.1021/cr100352k. PMID   21711015.
  29. S.L. Schreiber (2009). "Organic chemistry: Molecular diversity by design". Nature. 457 (7226): 153–154. Bibcode:2009Natur.457..153S. doi: 10.1038/457153a . PMID   19129834.