Carl Heneghan | |
---|---|
Born | UK | January 23, 1968
Nationality | British |
Known for | epidemiology |
Scientific career | |
Fields | Medicine, epidemiology |
Institutions | University of Oxford, Kellogg College Centre for Evidence-Based Medicine |
Carl James Heneghan (born January 1968) is a British general practitioner physician, a clinical epidemiologist and a Fellow of Kellogg College. [1] [2] He is the director of the University of Oxford's Centre for Evidence-Based Medicine and former Editor-in-Chief of BMJ Evidence-Based Medicine. [3]
Heneghan is a Professor of Evidence-based medicine at the University of Oxford, NHS Urgent Care General Practitioner, and co-director of the Global Centre for Healthcare and Urbanisation. [4] Heneghan's work includes investigating the evidence for approval of drugs and devices, assessing health claims, and researching common presenting conditions in the community. [5] He has expertise in medical device regulations, diagnosis, screening and avoidable harms: including analyses of antiviral medication Tamiflu, acute respiratory infections and the transmission of SARs-CoV-2. [6] [7] [8]
Professor Heneghan is the Director of Programs in Evidence-Based Health Care at the University of Oxford, running since 2000 as the largest part time program in the Medical Sciences Division. [9] Heneghan writes regularly in the media, including at the Spectator and, along with Tom Jefferson, created the substack Trust the Evidence. [10] [11]
Heneghan is one of the founders of AllTrials, an international initiative which calls for all studies to be published, and their results reported. [12] He is a member of the Scientific Advisory Board of Collateral Global, an organisation that examines the global impact of the COVID-19 restrictions. [13] He has also been a clinical advisor to three UK All Parliamentary Party Groups, including on the use of surgical mesh, and has advised the World Health Organisation's clinical trials registry platform. [14] [15]
In 2013, Heneghan was voted on to the Health Service Journal's list of top 100 most influential clinical leaders in England. [16] He was awarded NIHR Senior Investigation status in 2018. [17] Heneghan received a lifetime achievement award in 2019 from Oxford's Medical Science Division, for his sustained commitment to education and teaching. [18]
On 21 September 2020, Heneghan alongside Sunetra Gupta, Karol Sikora and 28 signatories wrote an open letter to the UK prime minister, chancellor and chief medical officers asking for a rethink of the government's COVID-19 strategy. They argued in favour of a targeted approach to lockdowns advising that only over-65s and the vulnerable should be shielded. [19] [20]
During the pandemic, Heneghan has written for The Spectator magazine. In it, he has commentated on various aspects of the UK's governments response to the COVID-19 pandemic. On 19 November 2020, he wrote an article with Tom Jefferson, an epidemiologist, in which he criticised the science behind wearing face masks to reduce transmissions of COVID-19. [21] In the article he stated that; "Now we have properly rigorous scientific research that we can rely on, the evidence shows that wearing masks in the community does not significantly reduce the rates of infection." His claim was met with criticism. Sonia Sodha of The Guardian argued that Heneghan had made scientific errors because he had misrepresented a Danish randomized controlled trial which studied infection transmission rates on people who wore face masks. This was because the Danish mask study was only focused on infection transmissions for those wearing masks, rather than on the overall community, so could not be used to make judgements on the effects of face masks on community wide transmission rates. [22]
Kamran Abbasi, executive editor of the British Medical Journal (BMJ), also criticised Heneghan's claims about face masks because he believed his interpretation of the Danish study was inaccurate. However, Abbasi stressed that he believed it was wrong that Heneghan's opinion be marked as “false information" on Facebook because, as he wrote in the BMJ, "disagreement among experts, especially about interpretation of a study, is a common occurrence. It is the usual business of science." [23]
The National Institute for Health and Care Research (NIHR) is the British government's major funder of clinical, public health, social care and translational research. With a budget of over £1.2 billion in 2020–21, its mission is to "improve the health and wealth of the nation through research". The NIHR was established in 2006 under the government's Best Research for Best Health strategy, and is funded by the Department of Health and Social Care. As a research funder and research partner of the NHS, public health and social care, the NIHR complements the work of the Medical Research Council. NIHR focuses on translational research, clinical research and applied health and social care research.
Tom Jefferson is a British epidemiologist, based in Rome, Italy, who works for the Cochrane Collaboration. Jefferson is an author and editor of the Cochrane Collaboration's acute respiratory infections group, as well as part of four other Cochrane groups. He was also an advisor to the Italian National Agency for Regional Health Services.
The Centre for Evidence-Based Medicine (CEBM), based in the Nuffield Department of Primary Care Health Sciences at the University of Oxford, is an academic-led centre dedicated to the practice, teaching, and dissemination of high quality evidence-based medicine to improve healthcare in everyday clinical practice. CEBM was founded by David Sackett in 1995. It was subsequently directed by Brian Haynes and Paul Glasziou. Since 2010 it has been led by Professor Carl Heneghan, a clinical epidemiologist and general practitioner.
Robert E. MacLaren FMedSci FRCOphth FRCS FACS VR is a British ophthalmologist who has led pioneering work in the treatment of blindness caused by diseases of the retina. He is Professor of Ophthalmology at the University of Oxford and Honorary Professor of Ophthalmology at the UCL Institute of Ophthalmology. He is a Consultant Ophthalmologist at the Oxford Eye Hospital. He is also an Honorary Consultant Vitreo-retinal Surgeon at the Moorfields Eye Hospital. MacLaren is an NIHR Senior Investigator, or lead researcher, for the speciality of Ophthalmology. In addition, he is a member of the research committee of Euretina: the European Society of Retina specialists, Fellow of Merton College, in Oxford and a Fellow of the Higher Education Academy.
Coronavirus disease 2019 (COVID-19) is a contagious disease caused by the coronavirus SARS-CoV-2. The first known case was identified in Wuhan, China, in December 2019. Most scientists believe the SARS-CoV-2 virus entered into human populations through natural zoonosis, similar to the SARS-CoV-1 and MERS-CoV outbreaks, and consistent with other pandemics in human history. Social and environmental factors including climate change, natural ecosystem destruction and wildlife trade increased the likelihood of such zoonotic spillover. The disease quickly spread worldwide, resulting in the COVID-19 pandemic.
Drug repositioning is the repurposing of an approved drug for the treatment of a different disease or medical condition than that for which it was originally developed. This is one line of scientific research which is being pursued to develop safe and effective COVID-19 treatments. Other research directions include the development of a COVID-19 vaccine and convalescent plasma transfusion.
During the COVID-19 pandemic, face masks or coverings, including N95, FFP2, surgical, and cloth masks, have been employed as public and personal health control measures against the spread of SARS-CoV-2, the virus that causes COVID-19.
Sir Peter William Horby is a British physician, epidemiologist, Moh Family Foundation Professor of Emerging Infections and Global Health, and Director of the Pandemic Sciences Institute at the University of Oxford. He is the founder, and former director of the Oxford University Clinical Research Unit in Hanoi, Vietnam which was founded in 2006. In 2014, Horby established the Epidemic Research Group Oxford (ERGO). ERGO incorporates a number of international projects such as the European Commission funded PREPARE, the African coaLition for Epidemic Research, Response and Training (ALERRT), and the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC). Since 2016, Horby has been chair and executive director of ISARIC.
The Randomised Evaluation of COVID-19 Therapy is a large-enrollment clinical trial of possible treatments for people in the United Kingdom admitted to hospital with severe COVID-19 infection. The trial was later expanded to Indonesia, Nepal and Vietnam. The trial has tested ten interventions on adults: eight repurposed drugs, one newly developed drug and convalescent plasma.
Marian Knight is a British physician who is a Professor of Maternal and Child Population Health at the University of Oxford. She is an Honorary Consultant of Public Health for Public Health England. During the COVID-19 pandemic Knight studied the characteristics and outcomes of pregnant women who tested positive for COVID-19.
The transmission of COVID-19 is the passing of coronavirus disease 2019 from person to person. COVID-19 is mainly transmitted when people breathe in air contaminated by droplets/aerosols and small airborne particles containing the virus. Infected people exhale those particles as they breathe, talk, cough, sneeze, or sing. Transmission is more likely the closer people are. However, infection can occur over longer distances, particularly indoors.
Azeem Majeed is a Professor and Head of the Department of Primary Care & Public Health at Imperial College, London, as well as a general practitioner in South London and a consultant in public health. In the most recent UK University Research Excellence Framework results, Imperial College London was the highest ranked university in the UK for the quality of research in the “Public Health, Health Services and Primary Care” unit of assessment.
Long COVID or long-haul COVID is a group of health problems persisting or developing after an initial period of COVID-19 infection. Symptoms can last weeks, months or years and are often debilitating. The World Health Organization defines long COVID as starting three months after the initial COVID-19 infection, but other agencies define it as starting at four weeks after the initial infection.
Sir Andrew John Pollard is the Ashall Professor of Infection & Immunity at the University of Oxford and a Fellow of St Cross College, Oxford. He is an Honorary Consultant Paediatrician at John Radcliffe Hospital and the Director of the Oxford Vaccine Group. He is the Chief Investigator on the University of Oxford COVID-19 Vaccine trials and has led research on vaccines for many life-threatening infectious diseases including typhoid fever, Neisseria meningitidis, Haemophilus influenzae type b, streptococcus pneumoniae, pertussis, influenza, rabies, and Ebola.
Sir Martin Jonathan Landray is a British physician, epidemiologist and data scientist who serves as a Professor of Medicine & Epidemiology at the University of Oxford. Landray designs, conducts and analyses large-scale randomised control trials; including practice-changing international trials that have recruited over 100,000 individuals. Landray previously led the health informatics team that enabled the collection and management of data for the UK Biobank on over half a million people.
Shabir Ahmed Madhi, is a South African physician who is professor of vaccinology and director of the South African Medical Research Council Respiratory and Meningeal Pathogens Research Unit at the University of the Witwatersrand, and National Research Foundation/Department of Science and Technology Research Chair in Vaccine Preventable Diseases. In January 2021, he was appointed Dean of the Faculty of Health Sciences at the University of the Witwatersrand.
The UK Covid-19 Inquiry is an ongoing, independent public inquiry into the United Kingdom's response to, and the impact of, the COVID-19 pandemic, and to learn lessons for the future. Public hearings began in June 2023. Boris Johnson announced the inquiry in May 2021, to start in Spring 2022. In December 2021, Heather Hallett was announced as the chair of the inquiry.
Susanna Jane Dunachie is a British microbiologist who is Professor of Infectious Diseases at the University of Oxford. Her work considers microbiology and immunology to better understand bacterial infection and accelerate the development of vaccines. She has focused on melioidosis, scrub typhus and tuberculosis. During the COVID-19 pandemic, she studied T cell immunity to severe acute respiratory syndrome coronavirus 2.
The Platform Adaptive Trial of Novel Antivirals for Early Treatment of COVID-19 in the Community is a clinical trial in the United Kingdom to test the effectiveness of new antiviral drugs at the early stages of COVID-19 infections. The study aims to find out if antivirals can prevent the need for hospitalisation and help faster recovery for people aged over 50 and those at higher risk due to underlying health conditions. PANORAMIC is sponsored by the University of Oxford and funded by the National Institute for Health and Care Research (NIHR). The trial was launched in December 2021, and as of June 2022, over 25,000 people are enrolled as participants.
Anthony Gordon is a British clinician scientist and the Chair of Anaesthesia & Critical Care at Imperial College London and works as an intensive care consultant at Imperial College Healthcare NHS Trust.
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