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Scarlet fever, also known as scarlatina, is an infectious disease caused by Streptococcus pyogenes, a Group A streptococcus (GAS). It most commonly affects children between five and 15 years of age. The signs and symptoms include a sore throat, fever, headache, swollen lymph nodes, and a characteristic rash. The face is flushed and the rash is red and blanching. It typically feels like sandpaper and the tongue may be red and bumpy. The rash occurs as a result of capillary damage by exotoxins produced by S.pyogenes. On darker-pigmented skin the rash may be hard to discern.
The DPT vaccine or DTP vaccine is a class of combination vaccines to protect against three infectious diseases in humans: diphtheria, pertussis, and tetanus (lockjaw). The vaccine components include diphtheria and tetanus toxoids, and either killed whole cells of the bacterium that causes pertussis or pertussis antigens. The term toxoid refers to vaccines which use an inactivated toxin produced by the pathogen which they are targeted against to generate an immune response. In this way, the toxoid vaccine generates an immune response which is targeted against the toxin which is produced by the pathogen and causes disease, rather than a vaccine which is targeted against the pathogen itself. The whole cells or antigens will be depicted as either "DTwP" or "DTaP", where the lower-case "w" indicates whole-cell inactivated pertussis and the lower-case "a" stands for "acellular". In comparison to alternative vaccine types, such as live attenuated vaccines, the DTP vaccine does not contain any live pathogen, but rather uses inactivated toxoid to generate an immune response; therefore, there is not a risk of use in populations that are immune compromised since there is not any known risk of causing the disease itself. As a result, the DTP vaccine is considered a safe vaccine to use in anyone and it generates a much more targeted immune response specific for the pathogen of interest.
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Group B streptococcal infection, also known as Group B streptococcal disease or just Group B strep infection, is the infectious disease caused by the bacterium Streptococcus agalactiae. Streptococcus agalactiae is the most common human pathogen belonging to group B of the Lancefield classification of streptococci—hence the name of group B stretococcal (GBS). Infection with GBS can cause serious illness and sometimes death, especially in newborns, the elderly, and people with compromised immune systems. The most severe form of group B streptococcal disease is neonatal meningitis in infants, which is frequently lethal and can cause permanent neuro-cognitive impairment.
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Shabir Ahmed Madhi, is a South African physician who is professor of vaccinology and director of the South African Medical Research Council Respiratory and Meningeal Pathogens Research Unit at the University of the Witwatersrand, and National Research Foundation/Department of Science and Technology Research Chair in Vaccine Preventable Diseases. In January 2021, he was appointed Dean of the Faculty of Health Sciences at the University of the Witwatersrand.
Anne Gershon is an infectious disease researcher and professor of pediatrics at Columbia University. She is best known for her work on the varicella-zoster virus, the causative agent for chickenpox. In the 1970s, she ran clinical trials for the varicella vaccine which showed that the vaccine was safe for children with leukemia. She also developed the first sensitive test for chickenpox.
References
- ↑ "A Career Dedicated to Protecting Pregnant Mothers and Infants with Carol J. Baker, MD – NFID".
- ↑ Bodwell, Greg (11 April 2019). "Dr. Carol Baker, Champion of Maternal and Newborn Health, Awarded 2019 Sabin Gold Medal". Sabin Vaccine Institute.
- ↑ Baker, Carol J.; Rench, Marcia A.; Edwards, Morven S.; Carpenter, Robert J.; Hays, Bethany M.; Kasper, Dennis L. (3 November 1988). "Immunization of Pregnant Women with a Polysaccharide Vaccine of Group B Streptococcus". New England Journal of Medicine. 319 (18): 1180–1185. doi:10.1056/NEJM198811033191802. PMID 3050524.
- ↑ "Q&A with Dr Carol J Baker". Group B Strep Support.
